Results 81 to 90 of about 7,895,670 (311)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Right before the end: asset decumulation at the end of life [PDF]

Using data from the Asset and Health Dynamics of the Oldest Old survey, the authors find that the assets of people who die decline much faster than the assets of people who survive, even after controlling for age, sex, and initial asset levels.
Eric French, John Bailey Jones, Mariacristina De Nardi, Olesya Baker, Phil Doctor   +4 more
core  

Quality of End-of-Life Cancer Care for Medicare Beneficiaries [PDF]

, 2010
The report shows that many challenges remain to improving the care of patients with serious, life-limiting illness. For more than 20 years, the Dartmouth Atlas Project has documented glaring variations in how medical resources are distributed and used in

core  

Evidence-based planning and costing palliative care services for children : novel multi-method epidemiological and economic exemplar [PDF]

, 2013
Background: Children’s palliative care is a relatively new clinical specialty. Its nature is multi-dimensional and its delivery necessarily multi-professional.
A Craft, Audit Scotland, C Feudtner, C Knapp, Ciarán Humphreys, D Bainbridge, Department of Health, Department of Health Western Australia, F Finlay, Gareth R Davies, J Noyes, J Noyes, Jane Noyes, K Lowson, K McNamara-Goodger, L Brook, L Fraser, Llinos Haf Spencer, Lucie Hobson, M Doug, Mary Devins, Mary Lewis, NPC, Public Health Wales, R Hain, R Hain, R Hain, R Hain, Rhiannon Tudor Edwards, Richard Hain, Richard P Hastings, Scottish Children and Young People's Palliative Care Executive Group (SCYPPEx), T Hughes-Hallet, Together for Short Lives, V Sugar, Vasiliki Totsika, Virginia Bennett, World Health Organisation   +37 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

“The great escape”: how an incident of elopement gave rise to trauma informed palliative care for a patient experiencing multiple disadvantage

BMC Palliative Care
Background This case report from Scotland, UK illustrates how unresolved traumatic experiences across the life course can affect a patient’s engagement with palliative care and offers insights into the flexibility and adaptations necessary for taking a ...
Sam Quinn, Libby Ferguson, Derek Read, Naomi Richards   +3 more
doaj   +1 more source

When is hastened death considered suicide? A systematically conducted literature review about palliative care professionals’ experiences where assisted dying is legal

BMC Palliative Care, 2019
Background Laws allowing assisted suicide and euthanasia have been implemented in many locations around the world but some individuals suffering with terminal illness receiving palliative care services are hastening death or die by suicide without ...
Sheri Mila Gerson, Amanda Bingley, Nancy Preston, Anne Grinyer   +3 more
doaj   +1 more source

End of Life Care: The Importance of Culture and Ethnicity [PDF]

, 2010
Despite Australia's cultural diversity, there is little doubt that ethnic minority groups continue to have less access to health care systems, let alone culturally appropriate care, including palliative and end of life care.
Jane Phillips
core  

A systematic review and critical appraisal of quality indicators to assess optimal palliative care for older people with dementia [PDF]

, 2019
© The Author(s) 2019Background: A challenge for commissioners and providers of end-of-life care in dementia is to translate recommendations for good or effective care into quality indicators that inform service development and evaluation.
Claire Goodman, Cohen J, De Koning J, Elizabeth L Sampson, Higginson I., Louise Robinson, Murtagh F., Sarah Amador, Volicer L   +8 more
core   +3 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source