FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Proceedings of the 24 May 2019 World Trade Institute Workshop held at the World Trade Organization, Geneva [PDF]
, 2019 E-book of contributions made at the WTI Workshop on WTO Appellate Review: Reform Proposals and Alternatives, held on 24 May 2019 at the World Trade Organization in Geneva.
core +1 more source
On Grief At The End Of The World
Performance PhilosophyShedding is personal process, an interpersonal practice, and a guide map to societal and structural justice. Guided by the wisdom of creatures who shed their skin, On Grief At The End Of The World is a reflection on a moment of personal apocalypse and a
Kai Hazelwood
doaj +1 more source
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
Summary of proceedings from the launch symposium, discussion, and proposed action plan for the England Centre for Practice Development’s international community of practice for end of life care [PDF]
, 2016 This paper provides a summary of summary of proceedings from the launch symposium, discussion, and proposed action plan for the England Centre for Practice Development’s International Community of Practice for End of Life Care held at The Spitfire ...
The England Centre for Practice Development International Community of Practice for End of Life Care +1 more
core
Uncovering the species diversity of subterranean rodents at the end of the World: three new species of Patagonian tuco-tucos (Rodentia, Hystricomorpha, Ctenomys). [PDF]
PeerJ, 2020 Teta P, D'Elía G.
europepmc +1 more source
How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
End of the world perspective to BCFT
European Physical Journal C: Particles and FieldsIn this work, we study the end-of-the-world (EOW) branes anchored to the boundaries of BCFT $${}_2$$ 2 dual to the BTZ black hole. First, we explore the thermodynamics of the boundary system consisting of the conformal boundary and two EOW branes.
Kyung Kiu Kim +4 more
doaj +1 more source
Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease
FEBS Letters, EarlyView.Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim +4 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source