Results 201 to 210 of about 319,431 (262)

Brown Adipocyte Sheets Alleviate Myocardial Ischemia–Reperfusion Injury Through NRG4–ErbB4–Dependent Ferroptosis Inhibition

Advanced Science, EarlyView.
Brown adipocyte sheets are engineered to protect the heart against myocardial ischemia–reperfusion injury by restraining ferroptosis. Upon transplantation onto the cardiac surface, they improve cardiac function, limit infarction and fibrosis, and enhance angiogenesis.
Lifu Sun, Yuting Liu, Jingbo Zhang, Takuji Kawamura, Junjun Li, Li Liu, Shigeru Miyagawa   +6 more
wiley   +1 more source

Hemodialysis and its effects on glymphatic system function in end-stage kidney disease patients. [PDF]

Quant Imaging Med Surg
Xiong Z, Wu M, Wang P, Zhang J, Yang J, Wang R, Shi T, Zeng X.   +7 more
europepmc   +1 more source

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, EarlyView.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

The RNA‐Binding Protein PARN Remodeled 3′ UTR Structure Defines Poly(A)‐Loading Sites to Mediate Immunoglobulin Homeostasis

Advanced Science, EarlyView.
ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun, Chen Yang, Xiaoyu Wang, Naijing Hu, Shengyao Zhang, Xinchun Li, Yu Chen, Jianan Zhai, Xiangfeng Tang, Wei Lu, Chenxu Lu, Changchang Cao, Weiru Yu, Wenhao Wu, Xiaonan Nie, Fengchao Wang, Bing Fang, Fazheng Ren, Yixuan Li, Juan Chen   +19 more
wiley   +1 more source

Renal Replacement Therapy in Lupus Nephritis-Related End-Stage Kidney Disease: A Systematic Review and Meta-Analysis. [PDF]

ACR Open Rheumatol
Kawtharany H, Jorge A, Azzam M, Bartels CM, Cunha JS, DeQuattro K, Fava A, Figueroa-Parra G, Garg S, Greco J, Cuéllar-Gutiérrez MC, Iyer P, Johannemann AS, Kasturi S, Khawandi J, Kirou KA, Legge A, Liang KV, Lockwood MM, Sanchez-Rodriguez A, Turgunbaev M, Williams JN, Sammaritano LR, Askanase A, Bermas BL, Dall'Era M, Duarte-García A, Hiraki LT, Rovin B, Son MBF, Turner AS, Mustafa RA.   +31 more
europepmc   +1 more source

Master Regulator SMC1A, Stabilized by N6‐Methyladenosine Reader IGF2BP1, Promotes HCC Progression Through Facilitating Enhancer–Promoter Interaction of Nestin

Advanced Science, EarlyView.
IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng, Diguang Wen, Lu Zeng, Lin Lv, Shengtao Liao, Wenguang Zhang, Zhechuan Mei, Chuanfei Li   +7 more
wiley   +1 more source

Patterns and Outcomes of Permanent Vascular Access in End-Stage Kidney Disease: A Multicenter Experience. [PDF]

Cureus
Alhubail FM, Al Mousa AM, Alhassan GM, Alali DS, Almutlaq MA, Almulhim M, El Tawil E, Salah G, Awad A.   +8 more
europepmc   +1 more source

Machine learning model for predicting hypotension following continuous renal replacement therapy initiation in end-stage kidney disease patients: a SHAP-interpretable approach. [PDF]

Front Med (Lausanne)
Qiu S, Qiu D, Tao Y, Fu P, Bai J, Cao N.
europepmc   +1 more source

Population Pharmacokinetic and Pharmacokinetic-Pharmacodynamic Analysis for Clazakizumab in Patients With End-Stage Kidney Disease Undergoing Dialysis. [PDF]

Clin Transl Sci
Muthukrishnan VY, Kerbusch T, Strong LE, Kleijn HJ, Pfister M, Chang AM, Acharya M, Nandy P, McCune JS.   +8 more
europepmc   +1 more source

Perioperative Bleeding Risk and Associated Factors in End-Stage Kidney Disease Patients Undergoing Intertrochanteric Fracture Surgery: Implications for Management. [PDF]

Orthop Res Rev
Wang Y, Gao H, Xu G, Wang B, Liu Z, Bai X, Ma J, Wang J, Chen W, Wang G.   +9 more
europepmc   +1 more source