Results 111 to 120 of about 684,976 (303)

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Palliative care and end stage liver disease: A cohort analysis of palliative care use and factors associated with referral

Annals of Hepatology
Introduction and Objectives: Prevalence and mortality of chronic liver disease have risen significantly. In end stage liver disease, the survival of patients is approximately two years. Despite the poor prognosis and high symptom burden of these patients,
Hugo M Oliveira, Helena Pessegueiro Miranda, Francisca Rego, Rui Nunes   +3 more
doaj   +1 more source

End-Stage Renal Disease in Familial Amyloidosis ATTR Val30Met: A [PDF]

, 2003
Transplant Proc. 2003 May;35(3):1116-20. End-stage renal disease in familial amyloidosis ATTR Val30Met: a definitive indication to combined liver-kidney transplantation.
Beirão, I., Henriques, A.C., Lobato, L., Miranda, H.P., Pereira, M.C., Sarmento, A.M., Seca, R., Teixeira, M., Ventura, A.   +8 more
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Cluster analysis of Model for End-stage Liver Disease and European System for Cardiac Operative Risk Evaluation for predicting operative mortality after concomitant tricuspid valve surgeryCentral MessagePerspective

JTCVS Structural and Endovascular
Objective: Patients requiring concomitant tricuspid surgery represent a heterogeneous cohort with significant comorbidities and varying degrees of organ and right ventricular dysfunction.
Kevin Lim, FRCS (Ed), Antony Chin Ching Au, MB ChB, Matthew Ming Hon Hui, MRCS (Ed), Ivan Chi Hin Siu, MRCS (Ed), Simon Chi Ying Chow, FRCS (Ed), Jacky Yan Kit Ho, FRCS (Ed), Song Wan, FRCS (Ed), FACC, Randolph Hung Leung Wong, FRCS (Ed)   +7 more
doaj   +1 more source

Assessment of health-related quality of life and related factors in patients with chronic liver disease

Brazilian Journal of Infectious Diseases, 2015
Background and objectives: Assessing health-related quality of life is an important aspect of clinical practice. Thus, the present study attempts to assess the health-related quality of life of patients with chronic liver disease.
Neila Paula de Souza, Livia Melo Villar, Artênio José Ísper Garbin, Tânia Adas Saliba Rovida, Cléa Adas Saliba Garbin   +4 more
doaj   +1 more source

Strength, muscle quality and functional capacity in liver transplanted familial amyloidotic polineuropathy patients [PDF]

, 2009
Liver transplantation is the unique treatment for several end-stage diseases. Familial Amiloidotic Polineuropathy (FAP) is a neurodegenerative disease related with systemic deposition of amyloidal fiber mainly on peripheral nervous system, clinically ...
Barroso, Eduardo, Cabri, Jan, Freire, António, Monteiro, Estela, Pimenta, Nuno, Santa-Clara, Helena, Tomás, Maria Teresa   +6 more
core   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Erectile Dysfunction in End-Stage Liver Disease Men

The Journal of Sexual Medicine, 2009
ABSTRACT Introduction In men, erectile dysfunction (ED) is an important issue. Data concerning ED in men with end-stage liver disease (ESLD) is limited, and the risk factors for ED in this population are still unknown.
Huyghe, Eric, Kamar, Nassim, Wagner, Fabien, Capietto, Aude-Hélène, El-Kahwaji, Labib, Muscari, Fabrice, Plante, Pierre, Rostaing, Lionel   +7 more
openaire   +3 more sources