Results 101 to 110 of about 351,631 (301)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Combined Liver-Kidney Transplantation for Hepatorenal Syndrome

International Journal of Organ Transplantation Medicine, 2015
Among various complications of end-stage liver disease, hepatorenal syndrome has the highest mortality. Patients with both end-stage liver disease and end-stage renal disease are candidates for combined liver-kidney transplantation.
V Kanubhai Sutariya, A Tank, P Ramanlal Modi   +2 more
doaj  

Elaboração de protocolo para cuidados intensivos pós-operatórios em pacientes submetidos a transplante hepático no Hospital Universitário Polydoro Ernani de São Thiago [PDF]

, 2015
Dissertação (mestrado profissional) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Cuidados Intensivos e Paliativos, Florianópolis, 2015.O transplante hepático surgiu durante a década de 1960, como ...
Lunardelli, Elizabeth Kristiane Buss
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Palliative care and end stage liver disease: A cohort analysis of palliative care use and factors associated with referral

Annals of Hepatology
Introduction and Objectives: Prevalence and mortality of chronic liver disease have risen significantly. In end stage liver disease, the survival of patients is approximately two years. Despite the poor prognosis and high symptom burden of these patients,
Hugo M Oliveira, Helena Pessegueiro Miranda, Francisca Rego, Rui Nunes   +3 more
doaj   +1 more source

End-stage liver disease as the only consequence of a mitochondrial respiratory chain deficiency: no contra-indication for liver transplantation

, 2000
The prerequisite for liver transplantation as a therapeutic option for inherited metabolic diseases should be that the enzyme defect, being responsible for the major clinical (hepatic and/or extra-hepatic) abnormalities, is localised in the liver ...
Jong, K.P. de, van Spronsen, FJ, de Jong, KP, Peeters, P.M., Reijngoud, D.J., Bijleveld, CMA, Smit, GPA, Reijngoud, DJ; id_orcid, Schweizer, JJ, Spronsen, D.J. van, Visser, G., Smit, G.P., Schweizer, J.J., Slooff, M.J.H., Peeters, PMJG, Slooff, MJH, Niezen-Koning, K.E., Ruitenbeek, W., Rake, JP, Visser, G, Bijleveld, C.M., Ruitenbeek, W, Niezen-Koning, KE; id_orcid, Niezen-Koning, KE, Reijngoud, DJ, Rake, J.P.   +25 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Reinfusion of highly purified CD133+ bone marrow-derived stem/progenitor cells in patients with end-stage liver disease: a phase I clinical trial

, 2015
Background: Bone marrow stem/progenitor cells seem to be effective in liver regeneration after tissueinjury. Aim: To evaluate the feasibility and safety of the mobilization and reinfusion of CD133+stem/progenitorcells in patients with end-stage liver ...
BERNARDI, MAURO, Montemurro, T, Casadei, Andrea, ANDREONE, PIETRO, Viganò, M, Foschi, F, Rizzi, S, Margini, C, Giordano, Rosaria, DAN, ELISA, CATANI, LUCIA, BRODOSI, LUCIA, Viganò, Mariele, Giudice, Valeria, Lorenzini, Stefania, Lemoli, R.M., Montemurro, Tiziana, Giudice, V, Foschi, Francesco G., CONTI, FABIO, LEMOLI, ROBERTO MASSIMO, Lorenzini, S, Rizzi, Simonetta, Giordano, R, NICOLINI, BENEDETTA, Margini, Cristina, SOLLAZZO, DARIA, MALVI, DEBORAH, Casadei, A   +28 more
core   +1 more source