Results 51 to 60 of about 351,631 (301)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Effect of end-stage liver disease on left atrial function

Al-Azhar Assiut Medical Journal, 2020
Background Hepatic cirrhosis causes structural and functional myocardial changes. Parameters of left atrial (LA) function provided novel insights and have prognostic significance in many cardiac patients.
Eman R Zaki, Eman R Mohamed, Mohamed A Elghobary, Eman E Elshemy   +3 more
doaj   +1 more source

Successful Liver Transplantation in Two Polish Brothers with Transaldolase Deficiency

Children, 2021
Transaldolase deficiency (TALDO; OMIM 606003) is a rare inborn autosomal-recessive error of the pentose phosphate pathway. It is an early-onset multisystem disease with dysmorphic features, anaemia, coagulopathy, thrombocytopenia, tubulopathy ...
Marek Stefanowicz, Maria Janowska, Joanna Pawłowska, Anna Tylki-Szymańska, Adam Kowalski, Marek Szymczak, Piotr Kaliciński, Irena Jankowska   +7 more
doaj   +1 more source

Bariatric Surgery and Risk of End-Stage Liver Disease in a Four-Country Cohort Study. [PDF]

Obes Surg
Background: Metabolic dysfunction-associated steatotic liver disease can progress to end-stage liver disease. Whether bariatric surgery influences this risk is uncertain.
Holmberg D, Santoni G, von Euler-Chelpin M, Kauppila JH, Ness-Jensen E, Lagergren J.   +5 more
europepmc   +2 more sources

Alterations of Endothelial Glycocalyx During Orthotopic Liver Transplantation in Patients With End-Stage Liver Disease.

, 2015
BACKGROUND Endothelial glycocalyx participates in the maintenance of vascular integrity, and its perturbations cause capillary leakage, loss of vascular responsiveness, and enhanced adhesion of leukocytes and platelets.
Berlakovich, Gabriela, Schiefer, Judith, Lebherz-Eichinger, Diana, Erdös, Gabor, Krenn, Claus G, Bacher, Andreas, Faybik, Peter   +6 more
core   +1 more source

A comprehensive review of coronary artery disease in patients with end-stage liver disease

, 2022
The prevalence of coronary artery disease has increased in patients with end stage liver disease. In the near future, non-alcoholic steatohepatitis is expected to be the leading cause of end stage liver disease and shares common risk factors with ...
Grant, Jelani K., Vianna, Rodrigo, Nicolau-Raducu, Ramona, Mendoza, Cesar, Braghiroli, Joao, Martin, Paul, Vincent, Louis, Sancassani, Rhea, Colombo, Rosario, Dangl, Michael, Eisenberg, Trevor   +10 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Utility of Serum YKL-40 as a Tumor-Specific Marker of Hepatobiliary Malignancies

Gut and Liver, 2010
Background/Aims: Serum YKL-40 has been linked to several human cancers. We investigated the potential role of serum YKL-40 as a marker of hepatobiliary malignancies.
doaj   +1 more source

Preoperative Nutritional Support in Children with End-Stage Liver-Disease Accepted for Liver-Transplantation - An Approach to Management

, 1990
Pre‐operative nutritional support was studied in 28 children with end‐stage liver disease awaiting orthotopic liver transplantation. Nasogastric supplemental administration of a standard semi‐elemental enteral nutritional formula was compared with a ...
Strong, R, Wilcox, J., Wilcox, J, Shepherd, R. W., Chin, S. E., Strong, R., Shepherd, RW, Cleghorn, GJ, Ong, TH, Cleghorn, G. J., Chin, SE, Patrick, M, Lynch, S, Patrick, M., Ong, T. H., Lynch, S.   +15 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source