Results 101 to 110 of about 45,958 (173)

APH Inhibitors that Reverse Aminoglycoside Resistance in Enterococcus casseliflavus

ChemMedChem, Volume 20, Issue 8, April 14, 2025.
Molecular dynamics simulations and in silico screening were used to identify non‐competitive inhibitors of APH, the enzymes that confer resistance to aminoglycoside antibiotics. A hit molecule showed activity against APH(2′′)‐IVa. Allosteric inhibition by the hit molecule and a two‐fold more potent analogue was confirmed by enzymatic measurements. Both
Elise Kaplan, Laurent Chaloin, Jean‐François Guichou, Kévin Berrou, Rahila Rahimova, Gilles Labesse, Corinne Lionne   +6 more
wiley   +1 more source

Bilateral endogenous endophthalmitis associated with infective endocarditis: case report

Brazilian Journal of Infectious Diseases, 2001
Bilateral endogenous endophthalmitis is a rare condition initiated by infection by microbes in the bloodstream, such as those arising from a foci of infective endocarditis. We report a case and discuss the diagnostic aspects and the clinical outcome of a
Arcieri Enyr Saran, Jorge Eduardo Ferreira, Ferreira Lizane de Abreu, Fonseca Maria B. da, Ferreira Magno Antônio, Arcieri Rafael Saran, Rocha Flávio Jaime   +6 more
doaj  

Detection of Serratia marcescens and Mierococcus lysodeikticus Bacterial Cells Using Cerium Oxide/Transition Metal Dichalcogenides Heterostructure‐Based Surface Plasmon Resonance Sensor

Advanced Photonics Research, Volume 6, Issue 4, April 2025.
A novel surface plasmon resonance sensor is developed using cerium oxide (CeO2) and transition metal dichalcogenides heterostructures for detecting Serratia marcescens and Micrococcus lysodeikticus bacterial cells. Based on the Kretschmann configuration, it achieves high sensitivity (369.40° RIU−1), quality factor (151.35 RIU⁻1), and detection accuracy
Yesudasu Vasimalla, Shivam Singh, Ramachandran Balaji, Satturappan Ravisekaran Srither, Santosh Kumar   +4 more
wiley   +1 more source

Optical detection of bacterial cells on stainless-steel surface with a low-magnification light microscope [PDF]

arXiv
A Rapid and cost-effective method for detecting bacterial cells on surfaces is critical to protect public health from various aspects, including food safety, clinical hygiene, and pharmacy quality. Herein, we first established an optical detection method based on a gold chip coating with 3-mercaptophenylboronic acid (3-MPBA) to capture bacterial cells,
arxiv  

Virulent Factor‐Targeted Point‐of‐Care Biosensor for Detection of Staphylococcus Aureus Infections

Advanced Sensor Research, Volume 4, Issue 4, April 2025.
In this work, the use of aureolysin as a biomarker of Staphylococcus Aureus infection in periprosthetic joint infection (PJI) is presented for the first time. Through the immobilization of an anti‐aureolysin antibody on gold nanospike‐modified screen‐printed electrodes, it is successfully detected aureolysin in both buffer solution and bacterial ...
Zahra Marvi, Yara Raphael, Dario Job, Graziele Cruzado, Geraldine Merle   +4 more
wiley   +1 more source

Heat and Hostility: How Substrate Temperature Shapes Bacterial Deposition Patterns and Pathogenesis in Evaporating Droplets [PDF]

arXiv
Hypothesis Droplets ejected from the host can directly settle on a substrate as fomite. In industrial environments, especially the food processing industries, the components maintained at specific temperatures can act as a substrate, leading to the fomite mode of infection.
arxiv  

Non‐Membrane Active Peptide Resensitizes MRSA to β‐Lactam Antibiotics and Inhibits S. aureus Virulence

Advanced Science, Volume 12, Issue 15, April 17, 2025.
This work identifies a potent, non‐membrane active, and non‐toxic AMP termed GN1, which substantially resensitizes MRSA to multiple β‐lactam antibiotics at low concentrations. GN1 functions by suppressing MRSA‐associated resistance determinants, including penicillin‐binding protein 2a (PBP2a) and β‐lactamase.
Jingru Shi, Chen Chen, Pan Kong, Feiyu Yu, Qingyan Lv, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

Systemic embolization due to non-bacterial thrombotic endocarditis: An autopsy case report and mini review of the literature

SAGE Open Medical Case Reports
Nonbacterial thrombotic endocarditis is a rare, non-infectious complication associated with hypercoagulable states, such as malignancies and autoimmune diseases.
Carmen Tisch, Daniel Ernst, Monika Falke, Philip Speicher, Mairi Ziaka   +4 more
doaj   +1 more source

Exploring Aspartate Transcarbamoylase: A Promising Broad‐Spectrum Target for Drug Development

ChemBioChem, Volume 26, Issue 7, April 1, 2025.
Pyrimidine biosynthesis is a pivotal process shared by both eukaryotes and prokaryotes. This review examines the applications and advantages of a series of inhibitors specifically designed to target aspartate transcarbamylase within the de novo biosynthetic pathway of the malarial parasite.
Siyao Chen, Queenie Mondile, XiaoChen Du, Chao Wang, Mayur Mukim, Carsten Wrenger, Alexander S. S. Dömling, Özlem Tastan Bishop, Matthew R. Groves   +8 more
wiley   +1 more source

Brucella Pneumonia Mimicking Pulmonary Tuberculosis: A Case Report

Clinical Case Reports, Volume 13, Issue 4, April 2025.
ABSTRACT Brucellosis is a zoonotic infection prevalent in certain regions. It typically presents with nonspecific symptoms but can also cause focal organ involvement, including the musculoskeletal, neurological, or pulmonary systems. Herein, we present a case of a 31‐year‐old male patient who presented with a 5‐day history of fever and cough.
Ammar Chapra, Rashid Kazman, Mhd Baraa Habib, Anas A. Ashour, Mohamed Sadek, Adila Shaukat   +5 more
wiley   +1 more source