Results 41 to 50 of about 47,832 (208)

Bifidobacterium longum subsp. longum CCFM1375 Mitigates Chronic Kidney Disease Progression via Gut Microbiota Modulation and Gut Barrier Restoration

Food Frontiers, EarlyView.
(1) Bifidobacterium longum subsp. longum CCFM1375 restored gut barrier integrity by upregulating ZO‐1/ZO‐2 and suppressing IL‐6/TNF‐α, thereby reducing serum LPS and improving creatinine/BUN levels. (2) Reshaped gut microbiota: enriched beneficial species (Faecalibaculum rodentium, Asaccharobacter celatus, Adlercreutzia equolifaciens) while suppressing
Hongchao Wang, Xinchen Lv, Yue Zhang, Jinlin Zhu, Jia Hua, Bin Liu, Jianxin Zhao, Hao Zhang, Wei Chen, Wenwei Lu, Zhijian Zhang, Liang Wang   +11 more
wiley   +1 more source

TargetGen‐RNN model discovers novel antibiotic compound targeting drug‐resistant Staphylococcus aureus

Interdisciplinary Medicine, EarlyView.
TargetGen‐recurrent neural network (RNN), an advanced generative model, generated 28,708 unique and novel compounds, identifying SAK‐2970 as a potent antibiotic against drug‐resistant Staphylococcus aureus. Exhibiting strong biofilm inhibition, high therapeutic efficacy, and minimal systemic toxicity in vivo, SAK‐2970 highlights its safety and clinical
Shakeel Ahmad Khan, Adnan Shakoor, Sadia Kanwal   +2 more
wiley   +1 more source

Secondary lung abscess caused by an esophagorespiratory fistula in a patient with a past history of heavy alcohol consumption

Journal of General and Family Medicine, EarlyView.
This case highlights the importance of considering malignancy‐related esophagorespiratory fistulas in patients with presumed aspiration‐related lung abscesses and heavy alcohol use. Abstract A man in his 60s was ultimately diagnosed with a secondary lung abscess caused by an esophagorespiratory fistula.
Shuhei Nozaki, Taku Yabuki, Taro Shimizu
wiley   +1 more source

PET-scan in diagnosis of non-bacterial thrombotic endocarditis: a case report

The Egyptian Heart Journal
Background Non-bacterial thrombotic endocarditis (NBTE), also known as marantic endocarditis or Libman–Sacks endocarditis, is a rare non-infectious condition affecting mostly the left-sided heart valves of patients who, most often, suffer from ...
Konstantinos Papakonstantinou, Filippos-Paschalis Rorris, Nikoleta Stanitsa, John Kokotsakis   +3 more
doaj   +1 more source

Surgical Options for Aortic Root Replacement in Destructive Endocarditis

Brazilian Journal of Cardiovascular Surgery
Objective: To analyze patients’ preoperative characteristics, surgical data, postoperative courses, and short- and long-term outcomes after implantation of different full-root prostheses for destructive aortic valve endocarditis.
Marcin Szczechowicz, Alexander Weymann, Sabreen Mkalaluh, Ahmed Mashhour, Konstantin Zhigalov, Jerry Easo   +5 more
doaj   +1 more source

Dose‐dependent association of systemic comorbidities with periodontitis severity: A large population cross‐sectional study

Journal of Periodontology, EarlyView.
Abstract Background To examine whether the associations between periodontitis and multiple systemic conditions increase with increasing severity of periodontitis using a multi‐center electronic health record (EHR) repository. Methods A cross‐sectional analysis was conducted using EHR data from 9 dental schools in the United States.
Muhammad H. A. Saleh, Hamoun Sabri
wiley   +1 more source

Reduced prevalence of periodontitis in antidepressant users: Findings from a large‐scale US sample

Journal of Periodontology, EarlyView.
Abstract Background Periodontitis and major depression disorder have been shown to have a bidirectional association. However, the impact of antidepressants, the primary pharmacological treatment for depression, on periodontal health remains unclear.
María Martínez, David Fraguas, Elena Figuero, Francesco D´Aiuto   +3 more
wiley   +1 more source

Case Report: Heart Transplantation for Refractory Candida tropicalis Endocarditis: A Case Report and Literature Review

Microorganisms
Candida infective endocarditis presents therapeutic challenges with high mortality. A complex case of Candida prosthetic valve endocarditis refractory to standard antifungals (anidulafungin and fluconazole) and high-dose caspofungin was successfully ...
Ricardo El Nouwar, Eva Larranaga Lapique, Frédéric Vanden Eynden, Delphine Martiny, Myriam Remmelink, Ana Roussoulières, Maya Hites   +6 more
doaj   +1 more source

Vanquish the vancomycin trough: a real‐world experience of pharmacist‐driven Bayesian software‐guided dosing using area under the curve (AUC) targets

Journal of Pharmacy Practice and Research, EarlyView.
Abstract Background A tertiary healthcare institution, located in New Zealand, switched from targeting trough vancomycin concentrations to 24‐h area under the concentration‐time curve (AUC24), facilitated by pharmacists using a Bayesian software‐guided approach.
Duncan Yorkston, Marie‐Claire Morahan, Vicki Campbell, Nirvana Selagan, Karensa Houghton, Sharon Gardiner, Paul Chin   +6 more
wiley   +1 more source

Safety of Baricitinib for the Treatment of Atopic Dermatitis in Adults Over a Median of 1.6 and up to 4.6 Years Treatment: Final Integrated Analysis of Eight Clinical Trials

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Baricitinib is a selective Janus kinase (JAK)1/JAK2 inhibitor approved in more than 70 countries for the treatment of moderate‐to‐severe atopic dermatitis (AD) in adults, and in over 30 countries for adolescents and children from age 2 years with moderate‐to‐severe AD, who are candidates for systemic therapy.
Antonio Costanzo, Antonio Torrelo, Eric L. Simpson, Marjolein De Bruin‐Weller, Diamant Thaçi, Norito Katoh, Silvia Sabatino, Andrew Buchanan, Kasia Morawska, Samuel Ogwu, Karen Denning, Jonathan I. Silverberg   +11 more
wiley   +1 more source