Results 71 to 80 of about 25,805 (234)

Elucidating the cellular determinants of the end‐systolic pressure‐volume relationship of the heart via computational modelling

The Journal of Physiology, EarlyView.
Abstract figure legend Using a multiscale computational model of left ventricular electromechanics, we investigated how sarcomere dynamics influence the end‐systolic pressure‐volume (ESPV) relationship in ejecting beats compared to isovolumetric beats.
Francesco Regazzoni, Corrado Poggesi, Cecilia Ferrantini   +2 more
wiley   +1 more source

Uncertainty quantification via polynomial chaos expansion of myocardial fibre orientation and cardiac activation patterns

The Journal of Physiology, EarlyView.
Abstract figure legend Graphical representation of methods. We implemented three biventricular geometric models (Zenger et al., 2020) with rule‐based myocardial fibre orientations (Bayer et al., 2018). We evaluated variability in the fibre orientation via four sets of parameter distributions to determine the role of the primary and imbrication angles ...
Lindsay C. R. Tanner, Anna Busatto, Jake A. Bergquist, Wilson W. Good, Brian Zenger, Gernot Plank, Akil Narayan, Karli Gillette, Rob S. MacLeod   +8 more
wiley   +1 more source

Effect of myocardial heterogeneity on ventricular electro-mechanical responses: a computational study

BioMedical Engineering OnLine, 2019
Background The heart wall exhibits three layers of different thicknesses: the outer epicardium, mid-myocardium, and inner endocardium. Among these layers, the mid-myocardium is typically the thickest.
Nida Dusturia, Seong Wook Choi, Kwang Soup Song, Ki Moo Lim   +3 more
doaj   +1 more source

Electrophysiological characterization of pre‐adolescents born with intrauterine growth restriction: insights from clinical and computational data

The Journal of Physiology, EarlyView.
Abstract figure legend Depolarization and repolarization duration analysis was conducted in preadolescent groups with IUGR and controls using a 12‐lead ECG. Principal component analysis was applied over the 12‐lead ECGs to generate spatially transformed leads better suited for robust ECG fiducial points detection.
Freddy L. Bueno‐Palomeque, Ernesto Zacur, Esther Pueyo, Fàtima Crispi, Pablo Laguna, Ana Mincholé   +5 more
wiley   +1 more source

The influence of delayed ventricular activation on cardiac repolarization: Insights from electrocardiographic imaging

The Journal of Physiology, EarlyView.
Abstract figure legend This study examines the relationships between activation and repolarization times in epicardial reconstructed unipolar electrograms derived from ECG‐imaging in patients with normal and delayed ventricular activation. In patients with a narrow QRS‐complex, ECG‐imaging reveals significant variability in the activation ...
Karin C. Smits, Ted E.M. Lempers, Marc Strik, Job Stoks, Roel Meiburg, Matthijs J.M. Cluitmans, Paul G.A. Volders, Kevin Vernooy, Frits W. Prinzen, Uyên Châu Nguyên   +9 more
wiley   +1 more source

Mesoscopic anatomy and histotopography of the left atrial appendage walls in human fetal heart

Сибирский научный медицинский журнал
Normal anatomy of the left atrial appendage (LAA) of human fetus is of a great importance for fetal cardiac surgery and heart bioprinting. Aim of the study was to clarify the mesoscopic anatomy and histotopography of different parts of the LAA walls in ...
A. A. Gaponov, I. D. Ufimtseva, E. G. Dmitrieva, D. K. Kuznetsov, V. I. Pryakhina, A. A. Iakimov   +5 more
doaj   +1 more source

Biomechanical signaling within the developing zebrafish heart attunes endocardial growth to myocardial chamber dimensions

Nature Communications, 2019
It is unknown how endocardium growth is coordinated with that of the myocardium in the zebrafish. Here, the authors show that myocardial chamber volume expansion causes increased endocardial tissue tension, which in turn triggers Hippo signaling-mediated
Dorothee Bornhorst, Peng Xia, Hiroyuki Nakajima, Chaitanya Dingare, Wiebke Herzog, Virginie Lecaudey, Naoki Mochizuki, Carl-Philipp Heisenberg, Deborah Yelon, Salim Abdelilah-Seyfried   +9 more
doaj   +1 more source

Ectopic Noggin in a Population of Nfatc1 Lineage Endocardial Progenitors Induces Embryonic Lethality

Journal of Cardiovascular Development and Disease, 2014
The initial heart is composed of a myocardial tube lined by endocardial cells. The TGFβ superfamily is known to play an important role, as BMPs from the myocardium signal to the overlying endocardium to create an environment for EMT.
Paige Snider, Olga Simmons, Jian Wang, Chinh Q. Hoang, Simon J. Conway   +4 more
doaj   +1 more source

Virtual left atrial appendage occlusion in paroxysmal atrial fibrillation during sinus rhythm predicts variable reductions in blood stasis

The Journal of Physiology, EarlyView.
Abstract figure legend Stasis before and after left atrial appendage occlusion (LAAO) in participants with high stasis and low stasis. Stasis is predominantly located in LAA and reduced after LAAO. But in the participant with high stasis, stasis remains close to the occlusion site, indicating a potential risk for device related thrombi.
Sophia Bäck, Jonas Lantz, Iulia Skoda, Lars O. Karlsson, Anders Persson, Carl‐Johan Carlhäll, Tino Ebbers   +6 more
wiley   +1 more source

Unveiling sex dimorphism in the healthy cardiac anatomy: Fundamental differences between male and female heart shapes

The Journal of Physiology, EarlyView.
Abstract figure legend We present a shape modelling‐based morphological analysis of sex differences in cardiac anatomy. We conduct our analysis on 456 healthy subjects from the UK Biobank (227M/229F) to uncover sex‐based differences in healthy cardiac morphology.
Beatrice Moscoloni, Cameron Beeche, Julio A. Chirinos, Patrick Segers, Mathias Peirlinck   +4 more
wiley   +1 more source