Results 221 to 230 of about 159,577 (267)

Role of Testosterone Signaling in Microglia: A Potential Role for Sex‐Related Differences in Alzheimer's Disease

Advanced Science, EarlyView.
Testosterone enhances Aβ‐induced autophagy in microglia via the non‐genomic testosterone receptor GPRC6A, promoting Aβ clearance by suppressing ERK phosphorylation and inhibiting mTOR activation. In male 5xFAD mice, testicular removal reduces microglial autophagy and Aβ clearance, which is restored by testosterone.
Haiyan Du, Akiko Mizokami, Junjun Ni, Simeng Zhang, Yosuke Yamawaki, Tomomi Sano, Eijiro Jimi, Isei Tanida, Takashi Kanematsu   +8 more
wiley   +1 more source

PPY‐Induced iCAFs Cultivate an Immunosuppressive Microenvironment in Pancreatic Cancer

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma features abundant stromal components that hinder therapy efficacy. Single‐cell RNA sequencing analysis combined with experiments identified PPY, a gastrointestinal hormone, as a novel inducer of immunosuppressive iCAFs. Mechanistic studies revealed that PPY activates the non‐canonical NF‐κB pathway via EGFR.
Mengdie Cao, Wang Peng, Bin Cheng, Ronghua Wang, Wei Chen, Luyao Liu, Hai Huang, Shiru Chen, Haochen Cui, JingWen Liang, Qiaodan Zhou, Si Xiong, Shuya Bai, Luoxia Liu, Yuchong Zhao   +14 more
wiley   +1 more source

Single‐Cell Atlas Reveals Tumorigenic Profiles and Immune Dynamics of Adrenal Incidentalomas

Advanced Science, EarlyView.
Single‐cell RNA sequencing reveals cellular heterogeneity in adrenal incidentalomas, identifying distinct tumor cell populations. Clusterin is recognized as a biomarker for adrenocortical tumors, correlating with established markers. MYCN‐positive clusters in pheochromocytomas indicated poorer survival.
Meng Wang, Guangmin Zheng, Xiaoyong Hu, Feng Tian, Tuo Li, Zheng Zhang, Kan Gong, Shiwei Chen, Lin Yuan, Yu Qi, Lin Li, Daofu Cheng, Liu Liu, Fuqiang Liu, Yujing Sun, Xiangdong Fang, Ruxing Zhao, Bing Liu, Chao Zhang   +18 more
wiley   +1 more source

ZNHIT3 Regulates Translation to Ensure Cell Lineage Differentiation in Mouse Preimplantation Development

Advanced Science, EarlyView.
Box C/D snoRNP complex regulates protein translation. This study identifies ZNHIT3 as a key component of the complex and ensures normal protein expression, including transcription factors orchestrating cell fate commitment, during early mouse embryogenesis.
Guanghui Yang, Qiliang Xin, Jurrien Dean
wiley   +1 more source

DAPK3 is Essential for DBP‐Induced Autophagy of Mouse Leydig Cells

Advanced Science, EarlyView.
This study has confirmed that death‐associated protein kinase 3 (DAPK3) is essential for dibutyl phthalate (DBP)‐induced autophagy of mouse Leydig cells, and is regulated by both transcription factor specific protein 2 (Sp2) and parkin RBR E3 ubiquitin‐protein ligase (PRKN), and melatonin can alleviate DBP‐induced autophagy of the cells.
Si Yang, Ying Yang, Linlin Xu, Chaoju Hao, Jiaxiang Chen   +4 more
wiley   +1 more source

A Model of Epigenetic Inheritance Accounts for Unexpected Adaptation to Unforeseen Challenges

Advanced Science, EarlyView.
A general model of inheriting changes that are acquired during the lifetime of individuals demonstrates tremendous benefits to the population, including escape from extinction in changing environments. Contrasting the model with experimental data shows that inheritance of acquired changes enables rapid adaptation to unforeseen challenges, and accounts ...
Dino Osmanović, Yitzhak Rabin, Yoav Soen   +2 more
wiley   +1 more source

Sperm‐Derived CircRNA‐1572 Regulates Embryogenesis and Zygotic Genome Activation by Targeting CCNB2 via Bta‐miR‐2478‐L‐2

Advanced Science, EarlyView.
Sperm‐derived circRNA‐1572 competitively binds to bta‐miR‐2478‐L‐2 through a “sponge” mechanism to regulate cyclin B2 (CCNB2) expression, thereby modulating the distribution of fibrous actin (F‐actin) in early pig embryos, ensuring proper chromosome segregation during mitosis, and facilitating normal embryo cleavage and zygotic genome activation.
Yanfang Wu, Yaochang Wei, Yuelin Li, Yiming Dou, YongQiang Yang, Hanghang Liu, Xiaoyan Wang, Zheng Wang, Jianmin Su, Yong Zhang, Yongsheng Wang   +10 more
wiley   +1 more source

Pupylation‐Based Proximity Labeling Unravels a Comprehensive Protein and Phosphoprotein Interactome of the Arabidopsis TOR Complex

Advanced Science, EarlyView.
The target of rapamycin (TOR) complex is a central plant growth regulator. Here, the protein–protein interactions underlying its various functions are mapped by pupylation‐based proximity‐labeling in Arabidopsis, using TOR complex subunits LST8‐1 and RAPTOR1, alongside TOR inhibitor FK506‐binding protein, as baits.
Shuai Zheng, Leonard Blaschek, Delphine Pottier, Luuk Robin Hoegen Dijkhof, Beyza Özmen, Peng Ken Lim, Qiao Wen Tan, Marek Mutwil, Alexander Sebastian Hauser, Staffan Persson   +9 more
wiley   +1 more source

Catheter Injectable Multifunctional Biomaterial for the Treatment of Infected Enterocutaneous Fistulas

Advanced Science, EarlyView.
A multi‐functional shear‐thinning hydrogel is engineered to treat enterocutaneous fistulas. This hydrogel can resist external pressures allowing it to remain within the fistula tract and is shown to have significant antimicrobial, pro‐healing, and anti‐inflammatory properties, which were validated in in vitro and in vivo experiments.
Jinjoo Kim, Zefu Zhang, Hassan Albadawi, Hyeongseop Keum, Joseph L. Mayer, Erin H. Graf, Rahmi Oklu   +6 more
wiley   +1 more source

Neuronal C/EBPβ Shortens the Lifespan via Inactivating NAMPT

Advanced Science, EarlyView.
Schematic diagram illustrating the mechanism of shortened lifespan in Thy 1‐C/EBPβ transgenic mice and intervention strategies. Briefly, C/EBPβ/AEP escalation in the aging brain triggers NAMPT fragmentation and NAD+ depletion. Knockout of AEP from Thy 1‐C/EBPβ Tg/Tg mice ameliorates cognitive impairments and elongates the lifespan.
Bowei Li, Zhongyun Xie, Mengmeng Wang, Shuke Nie, Zhengjiang Qian, Xin Meng, Xia Liu, Seong Su Kang, Keqiang Ye   +8 more
wiley   +1 more source