Results 61 to 70 of about 1,301,264 (280)

Hypothesis-driven weight of evidence evaluation indicates ethylbenzene lacks endocrine disruption potential by EATS pathways

EXCLI Journal : Experimental and Clinical Sciences
Ethylbenzene (EB) was placed on List 2 for Tier 1 endocrine screening in the U.S. EPA’s two-tiered Endocrine Disruptor Screening Program (EDSP) and was scheduled for evaluation under TSCA.
Christopher J. Borgert
doaj   +1 more source

Estrogênios em águas naturais e tratadas da região de Jaboticabal - São Paulo Estrogens in natural and treated waters in the region of Jaboticabal - São paulo, Brazil

Química Nova, 2010
The aim of this work was to analyze 17 β estradiol and estrone, natural estrogenic hormones present in domestic effluents and animal excreta, in the public water supply system of Jaboticabal, SP.
Laudicéia G. Lopes, Mary R. R. Marchi, João B. G. Souza, José A. Moura, Cintia S. Lorenzon, Claudinei Cruz, Luiz A. Amaral   +6 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Is Japan at low risk for PFAS immunotoxicity?: human biomonitoring study in contaminated areas in Japan

Environmental Health and Preventive Medicine
Background: Per- and polyfluoroalkyl substances (PFAS) are now considered global contaminants posing health risks. Recent human biomonitoring data in Japan are presented.
Zhaoqing Lyu, Kouji H. Harada, Junko Kimura-Kuroda, Yasuharu Tokuda   +3 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

AMAZON ACAI AND PINEAPPLE RESIDUES INDUCE THE ENZYME LACCASE IN Pleurotus ostreatus: APPLICATION TO BISPHENOL A BIOREMEDIATION [PDF]

Química Nova
Bisphenol A (BPA), an endocrine disruptor used in different commercial polymers, is a persistent pollutant commonly found in effluents. Conventional wastewater treatment processes have low chemical removal efficiency and are expensive.
Jhessica Cavalcante de Souza Golveia, Elaine Sousa Nunes, Thiago Souza Bulhões, Jerônimo Raimundo de Oliveira Neto, Luiz Carlos da Cunha, Luiza Cintra Campos, Mariângela Fontes Santiago, Fernando Schimidt   +7 more
doaj   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

In Vitro Effects of the Endocrine Disruptor p,p’-DDT on Human Follitropin Receptor

Environmental Health Perspectives, 2016
Background: 1-chloro-4-[2,2,2-trichloro-1-(4-chlorophenyl)ethyl]benzene (p,p′-DDT) is a persistent environmental endocrine disruptor (ED). Several studies have shown an association between p,p′-DDT exposure and reproductive abnormalities.
M. Munier, Julie Grouleff, Louis Gourdin, M. Fauchard, Vanessa Chantreau, D. Henrion, R. Coutant, B. Schiøtt, M. Chabbert, P. Rodien   +9 more
semanticscholar   +1 more source

Pyriproxyfen, villain or good guy? A brief review [PDF]

Archives of Endocrinology and Metabolism
Pyriproxyfen (PPF) acts as a juvenile growth regulator, interfering with normal metamorphosis and blocking the development of insects into adulthood. Although the World Health Organization (WHO) considers the use of PPF at a concentration of 0.01 mg/L as
Andressa Pereira Cabral, Fabrício Pereira dos Santos Maia, D’Angelo Carlo Magliano, Jones Bernardes Graceli, Paula Soares, Eduardo Andrés Rios Morris, Leandro Miranda-Alves   +6 more
doaj   +1 more source