Results 261 to 270 of about 35,443 (336)

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

Look What You Made Me Do: Discerning Feature for Classification of Endocrine-Disrupting Chemical Binding to Steroid Hormone Receptors [PDF]

Azam Rashidian, Sini Pitkänen, Vinícius Gonçalves Maltarollo, Ulrich Schoppmeier, Ekaterina Shevchenko, Prasanthi Medarametla, Antti Poso, Jenni Küblbeck, Paavo Honkakoski, Thales Kronenberger   +9 more
openalex   +1 more source

Environmental endocrine disruptors and endometrial cancer risk: a systematic review and meta-analysis of cadmium and polychlorinated biphenyls, with emerging evidence on PFAS, phthalates, and bisphenols. [PDF]

Front Oncol
Gong L, Lu W, Zhao Y, Mei H, Zhang X.
europepmc   +1 more source

A Virus‐Inducible E3–RLCK–MADS Module Coordinates Suppression of Plant Immunity and Fertility in Rice

Advanced Science, EarlyView.
ABSTRACT Viruses often hijack host developmental programs to promote infection, but the mechanistic links between reproductive regulation and antiviral immunity remain incompletely understood. Here, we identify a virus‐triggered hierarchical degradation cascade that links antiviral immunity and fertility regulation in rice. We show that the rice grassy
Yuansheng Wu, Fengling Wu, Shiting Huang, Denglu Yang, Xin Lei, Xue Zhang, Na Liu, Peng Gan, Chuan Li, Jie Zhang, Ming Wu, Qingxiao Jia, Shanshan Zhao, Jianguo Wu   +13 more
wiley   +1 more source

New approach methodologies (NAMs) for improved developmental and reproductive toxicity (DART) assessment with focus on endocrine disruption – a PARC project [PDF]

Jacob Ardenkjær-Skinnerup, Yoni Baert, Lola Bajard, Jonathan Blum, François Brion, Lucia Coppola, Jean‐Baptiste Fini, Ellen Fritsche, Henrik Holbech, Selma Hurem, Miriam Naomi Jacobs, Hanna Katarina Lilith Johansson, Dries Knapen, Katharina Koch, Jan Ludvig Lyche, Phuong Ngoc Thi, Winfried Neuhaus, N. Nikolov, Atika Nurani, Katerina Papageorgiou, Rikke Poulsen, Louise Ramhøj, Eliška Řehůřková, Anna Kjerstine Rosenmai, Joëlle Rüegg, Iva Sovadinová, Sabrina Tait, Mathew Van de Pette, Tamara Vanhaecke, Lucia Vergauwen, Eva Bay Wedebye, Elvis Genbo Xu, Terje Svingen   +32 more
openalex   +1 more source

Chemical Interference: A Review on Endocrine Disruptors and Reproductive Communication in Amphibians. [PDF]

Ecol Evol
Frątczak M, Kaczmarski M, Szkudelska K, Tryjanowski P.   +3 more
europepmc   +1 more source

Natural Resistance to Ovarian Hyperstimulation Syndrome in Estrildid Finches Reveals Macrophage GPR183 as a Potential Therapeutic Target

Advanced Science, EarlyView.
Ovarian macrophage depletion reverses OHSS resistance in estrildid finches and exacerbates OHSS symptoms in rats. Activating macrophage GPR183 alleviates OHSS by reducing pro‐inflammatory factors, increasing immunomodulatory molecules, remodeling CD44/SDC4‐mediated communication, and restoring immune homeostasis.
Xiaofei Yan, Yongjie Huang, Jiabao Yang, Su Ma, Songsong Liu, Xuan Huang, Juergen Brosius, Huaping Zheng, Bing Yao, Li Chen, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Developmental programming and endocrine disruptor effects on reproductive neuroendocrine systems

, 2008
Andrea C. Gore
openalex   +2 more sources

Integrating network toxicology, machine learning, and single-cell sequencing to reveal the FASN-mediated role of phenolic endocrine disruptors in water in promoting prostate cancer. [PDF]

PLoS One
Zhu X, Wu Q, Li Y, Liu Z, Zeng Y, Zeng Z, Zhou Y, Zou L, Wu X, Zhao D, Deng Q, Zhou T.   +11 more
europepmc   +1 more source

SERRATE Regulates Floral Meristem Activity by Antagonizing SHOOT MERISTEMLESS and Repressing Cytokinin Signaling

Advanced Science, EarlyView.
Floral meristem (FM) activity is crucial for the initiation of floral organs. In this study, SE represses IPT7 expression and cytokinin signaling via both the miR171c‐5p–KNAT2 and miR164c–CUC1/2–KNAT2 regulatory modules, thereby repressing FM activity. In contrast, STM induces both KNAT2 and IPT7 expression.
Wen Yang, Yiting Wang, Yuxin You, Zhiyue Wu, Dongbao Li, Xin Wang, Yongsheng Chang, Hang Zhao, Tao Zhu, Dijun Chen, Wei Chen, Bo Sun   +11 more
wiley   +1 more source