Results 91 to 100 of about 171,806 (336)

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

Characterization of the neuroendocrine pancreatic tumors nature by MDCT enhancement pattern: a radio-pathological correlation [PDF]

, 2012
Introduction Pre-operative suspicion of neuroendocrine pancreatic lesions nature arises both from clinical (presence and the type of secreted hormone) and imaging findings.
NOVARIA, LISA
core  

Evaluation of the current knowledge limitations in breast cancer research: a gap analysis [PDF]

, 2008
BACKGROUND A gap analysis was conducted to determine which areas of breast cancer research, if targeted by researchers and funding bodies, could produce the greatest impact on patients.
A Cox, A Howell, A Kamb, A Maurice, A Moyer, A Renwick, A Rodger, Adrian Harris, AH Eliassen, AH Sims, Alastair Thompson, Angela Cox, Anthony Howell, C Julian-Reynier, C Kuperwasser, CA Purdie, CD Wagner, CH Kroenke, Charles Streuli, CJ Watson, CJ Watson, CM Perou, D Sachdev, DF Easton, Diana Harcourt, DJ Britton, DJ Hunter, DM Abd El-Rehim, DM Harcourt, DS Main, E Amir, E Katz, E Tiligada, G Bon, GP Gui, GW Sledge, H Goulding, HE Huang, Ingunn Holen, International Agency for Research on Cancer Expert Group, IO Ellis, J Bogaerts, J Brennan, J Brett, J Corner, J Debnath, J Polanowska, J Stingl, J Teulière, JJ Dignam, JK Camoriano, JL Jones, JM Bartlett, JM Dixon, JM Gee, JT Scott, Julia Gee, JW Jonker, K Polyak, K Rennstam, KA Green, KE Sleeman, Keith Brennan, KJ Fowler, KL Schwertfeger, KR Brennan, KW Kinzler, L Cortesi, L Fallowfield, L Hennighausen, L Larue, L Lostumbo, LL Northouse, LS Freedman, M Adams, M Harvie, M Harvie, M Shackleton, M Sidani, M Tanner, M Zhang, MD Holmes, MD Sternlicht, MD Sternlicht, Michael Steel, Michelle Harvie, MJ Piccart-Gebhart, ML Asselin-Labat, ML McNeely, ML McNeely, MM Ip, MO Leach, N Barnes, N Rahman, N Sarwar, NG Howlett, P Dent, P Schofield, PA Kenny, R DasGupta, R Doll, R Leake, R Scully, R Serra, RA Walker, RB Clarke, Robert Nicholson, RT Chlebowski, S Anand, S Hiscox, S Seal, S Stylianou, SA Bingham, SE Moody, SJ Cleator, SK Sharan, SN Stacey, SR Johnston, T Sheard, T Sjöblom, T Sorlie, The Breast Cancer Association Consortium, The CHEK2 Breast Cancer Case-Control Consortium, V Aranda, V Speirs, VA McCormack, VG Vogel, WD Foulkes, X Yu, YL Low   +129 more
core   +4 more sources

Matrix Tropism Influences Endometriotic Cell Attachment Patterns

Advanced Functional Materials, EarlyView.
The influence of substrate stiffness and multicellular coculture on endometriotic cell attachment to extracellular matrix‐laden microarrayed islands is reported. This model investigates early endometriotic cell attachment, aiming to capture “lesion initiation events”.
Hannah S. Theriault, Hannah R.C. Kimmel, Alison C. Nunes, Allison L. Paxhia, Sarah Hashim, Kathryn B.H. Clancy, Gregory H. Underhill, Brendan A.C. Harley   +7 more
wiley   +1 more source

Fluoride and Pineal Gland

Applied Sciences, 2020
The pineal gland is an endocrine gland whose main function is the biosynthesis and secretion of melatonin, a hormone responsible for regulating circadian rhythms, e.g., the sleep/wake cycle.
Dariusz Chlubek, Maciej Sikora
doaj   +1 more source

Laparoscopic partial adrenalectomy for bilateral pheochromocytomas in a boy with von Hippel-Lindau disease [PDF]

, 2000
Objectives: In adults, increasing numbers of adrenalectomies for pheochromocytomas are performed laparoscopically. We report for the first time laparoscopic bilateral subtotal adrenalectomy for pheochromocytomas in an 8-year-old boy with von Hippel ...
Bartsch, Georg, Elsner, Romy, Janetschek, Günter, Neumann, Hartmut, Radmayr, Christian   +4 more
core   +1 more source

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

Advanced Healthcare Materials, Volume 14, Issue 17, July 4, 2025.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray, Shehzahdi S. Moonshi, Hang Thu Ta   +2 more
wiley   +1 more source

Glucocorticoids Alter Bone Microvascular Barrier via MAPK/Connexin43 Mechanisms

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
Osteoporosis induced by Glucocorticoids (GCs) is a common complication of long‐term GC use in patients with inflammatory and autoimmune conditions, often leading to an increased fracture risk. A 3D bicellular endo‐osteo microfluidic platform is developed to explore pathogenic mechanisms underlying GCs‐induced osteoporosis, highlighting a novel MAPK ...
Eun‐Jin Lee, Peter Lialios, Micaila Curtis, James Williams IV, Yoontae Kim, Paul Salipante, Steven Hudson, Mandy B. Esch, Moshe Levi, Joanna Kitlinska, Stella Alimperti   +10 more
wiley   +1 more source

Advanced Multipurpose Spectroscopic Nanobio‐Device for Concurrent Lab‐on‐a‐Chip Label‐Free Separation and Detection of Extracellular Vesicles as Key‐Biomarkers for Point‐of‐Care Cardiovascular Disease Diagnostics

Advanced Healthcare Materials, EarlyView.
AIMSPec‐LoC is a novel lab‐on‐a‐chip platform integrating size‐based extracellular vesicle (EVs) separation with label‐free Raman spectroscopy and AI‐powered classification via SKiNET. This high‐throughput, portable system enables real‐time, multiplexed molecular fingerprinting of EVs from biofluids, offering transformative potential for early, non ...
Emma Buchan, Jonathan James Stanley Rickard, Mark Robert Thomas, Pola Goldberg Oppenheimer   +3 more
wiley   +1 more source

Aging on Chip: Harnessing the Potential of Microfluidic Technologies in Aging and Rejuvenation Research

Advanced Healthcare Materials, EarlyView.
This review highlights recent advances in microfluidic technologies for modeling human aging and age‐related diseases. It explores how organ‐on‐chip platforms improve physiological relevance, enable rejuvenation strategies, facilitate drug screening, detect senescent cells, and identify biomarkers.
Limor Zwi‐Dantsis, Vignesh Jayarajan, George M. Church, Roger D. Kamm, João Pedro de Magalhães, Emad Moeendarbary   +5 more
wiley   +1 more source