Results 231 to 240 of about 796,161 (328)

Spatiotemporal Adaptations‐Driven Dynamic Thra Activation Simulates a Skin Wound Healing Response

open access: yesAdvanced Science, EarlyView.
This study uncovers the thyroid hormone receptor Thra as a pivotal regulator that spatiotemporally orchestrates dual‐phase skin repair. Epidermal Thra accelerates barrier restoration via glutathione‐driven keratin assembly, while dermal Thra establishes angiogenic niches through SAA3‐FN1‐mediated matrix remodeling.
Zeming Li   +15 more
wiley   +1 more source

Primary Burkitt Lymphoma of the Thyroid Associated With Hashimoto Thyroiditis Masquerading as Post-COVID Thyroiditis. [PDF]

open access: yesJCEM Case Rep
Thewjitcharoen Y   +5 more
europepmc   +1 more source

PD‐L1‐Targeting Biomimetic Photoresponsive Thermosensitive Liposomes for Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
Tan et al. developed a platelet membrane‐coated, thermoresponsive liposome for targeted, light‐controlled delivery of fluorinated peptides that promotes programmed death‐ligand 1 degradation, induces tumor immunogenic cell death, suppresses solid tumors and metastases, and triggers durable immune memory, offering a promising strategy for peptide‐based ...
Manman Tan   +19 more
wiley   +1 more source

Impact of 18F-choline PET-CT or PET-MRI on surgical strategy in patients with primary hyperparathyroidism. [PDF]

open access: yesBJS Open
Carrillo Lizarazo JL   +5 more
europepmc   +1 more source

ACSS2/AATF Drives Soluble FasL‐Mediated CD8+ T Cell Apoptosis in Pancreatic Neuroendocrine Tumors

open access: yesAdvanced Science, EarlyView.
This study unveils that ACSS2‐driven acetate metabolism fuels histone pan‐acetylation in pancreatic neuroendocrine tumors (PNETs), remodeling the epigenetic landscape. The ACSS2/AATF axis transcriptionally activates soluble FasL (sFasL), which engages Fas receptors on infiltrating CD8+ T cells to trigger caspase‐8/3‐mediated apoptosis.
Qin Dang   +14 more
wiley   +1 more source

KLK1 as an Epithelial‐Specific Brake Inhibits Colorectal Tumorigenesis by Suppressing B1R‐Mediated Fibroblast Phenotypic Transition

open access: yesAdvanced Science, EarlyView.
KLK1 downregulation disrupts the intestinal mucosal barrier and impairs kallikrein‐kinin signaling, thereby reducing Lys‐des‐Arg9‐BK production. This enhances B1R activation on ADAMDEC1⁺ fibroblasts, promoting inflammation and extracellular matrix (ECM) remodeling. The resulting iCAFs promote colorectal cancer progression, highlighting a novel KLK1‐B1R
Lisha Zhou   +14 more
wiley   +1 more source

Aldosterone-Producing Adrenal Oncocytoma: A Rare Cause of Primary Aldosteronism. [PDF]

open access: yesCureus
Kecaj I   +6 more
europepmc   +1 more source

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