Results 251 to 260 of about 796,161 (328)

Recent advances in anterior pituitary hormones and metabolic-associated fatty liver disease. [PDF]

Front Endocrinol (Lausanne)
Liu C, Long Y, Liu J, Song Y.
europepmc   +1 more source

Alternative Models for Anticancer Drug Discovery From Natural Products Using Binary Tumor‐Microenvironment‐on‐a‐Chip

Advanced Science, EarlyView.
This study presents a binary tumor‐microenvironment‐on‐a‐chip (T‐MOC) system incorporating multicellular tumor spheroids (MCTs) as an alternative preclinical platform to evaluate the efficacy of anticancer natural products. The T‐MOC model reproduces in vivo drug delivery barriers and physiological conditions, enabling morphological analysis to predict
Youngwon Kim, Si Hyeon Chae, Dahae Lee, Bum Soo Lee, Jiseok Lim, Hyo‐Il Jung, Ki Hyun Kim, Bongseop Kwak   +7 more
wiley   +1 more source

<i>RET</i> Y791F in MEN2: a variant presumed non-pathogenic, yet lacking conclusive evidence of insignificance. [PDF]

Gland Surg
Binter T, Niederle MB, Arikan M, Hargitai L, Schernthaner-Reiter MH, Baumgartner-Parzer S, Niederle B, Scheuba C, Riss P.   +8 more
europepmc   +1 more source

Bioinspired Prolactin Pulse Release from Responsive Microneedles for Inhibiting Fatty Liver Formation

Advanced Science, EarlyView.
Inspired by the prolactin secretion profile under normal physiological conditions, biomimetic prolactin‐releasing microneedles are designed. Under the control of near infrared (NIR), these responsive microneedles facilitate pulsed release of prolactin to inhibit fatty liver formation.
Hongli Yin, Wenjuan Tang, Danqing Huang, JingJing Gan, Pengzi Zhang, Yuanjin Zhao, Yan Bi   +6 more
wiley   +1 more source

A Case of Myxoid Malignant Peripheral Nerve Sheath Tumor in a Patient With Carney Complex. [PDF]

Case Rep Pathol
Kobayashi K, Suzui N, Shibata H, Ogawa T, Miyazaki T.   +4 more
europepmc   +1 more source

Biocompatible Mesoporous Materials for Bone Therapy

Advanced Science, EarlyView.
Biocompatible mesoporous materials (BMMs), characterized by high specific surface area, tunable pore size, different shapes and structures, and multidimensional functionalized modifications, have revolutionary applications in treating bone‐related diseases.
Biao Yu, Yan Wu, Yang Hong, Peng Wang, Xiaowen Liu, Yonghui Deng, Jiacan Su   +6 more
wiley   +1 more source

Double mutation for multiple endocrine neoplasia associated with congenital adrenal hyperplasia. [PDF]

Endocrinol Diabetes Metab Case Rep
de Oliveira WL, de Aguiar Silva EM, de Melo Oliveira CE, Alves Filho W, Martins Costa MC, Carvalho de Alencar R, de Almeida Vieira CA, Pinto Quidute AR.   +7 more
europepmc   +1 more source

Comparative Single‐Cell Transcriptomic Landscape Reveals the Regulatory Mechanisms of Lactation during Selective Breeding in Asian Water Buffalo

Advanced Science, EarlyView.
In this study, a comprehensive single‐cell transcriptome atlas of river and swamp buffalo, encompassing 12 tissues and 397,011 cells, is constructed. Differential expression analyses identify metabolic and secretory tissues and cell types that mediate the divergence of milk production.
Dongmei Dai, Jingfang Si, Li Jiang, Bo Han, Kailai Wang, Xue Wang, Shihui Yan, Yichang Yin, Wei Chen, Huaming Mao, Alfredo Pauciullo, Shang‐Tong Li, Lingzhao Fang, Yi Zhang   +13 more
wiley   +1 more source

Thyroid surgery outcomes in a 4-year series with intraoperative neuromonitoring: a retrospective cohort study. [PDF]

Gland Surg
Allen M, Palma C, Branco C, Resende C, Vieira N, Silva AL, Sobral do Rosário F.   +6 more
europepmc   +1 more source

Deficiency of Leucine‐Rich Repeat Containing G Protein‐Coupled Receptor 4 in Pancreas Reduces β Cell Mass

Advanced Science, EarlyView.
In islet β cells, LGR4 binds with Rspondin to activate the Wnt‐β‐catenin‐Ccnd1 axis, leading to a subsequent increase in cell proliferation. On the other hand, LGR4 also binds with RANKL, thus suppressing the phosphorylation of p44/p42 MAPK and p65 NF‐κB and subsequent cell apoptosis.
Chao Luo, Yifan Feng, Jiajie Min, Yan Zhao, Ziming Zhu, Lijun Sun, Hao Yin, Yue Yin, Weizhen Zhang   +8 more
wiley   +1 more source