Results 91 to 100 of about 801,043 (361)
Liraglutide for idiopathic intracranial hypertension: a real‐world propensity score‐matched study
Annals of Clinical and Translational Neurology, EarlyView.Abstract Objective Idiopathic intracranial hypertension (IIH) is a neurological disorder predominantly affecting young women with obesity, characterized by elevated intracranial pressure. While current treatments include weight loss counseling, medical therapies, and surgical interventions, their limitations necessitate exploring novel therapeutic ...
Ahmed Y. Azzam +13 more
wiley +1 more source
An automated and multi-parametric algorithm for objective analysis of meibography images [PDF]
arXiv, 2020 Meibography is a non-contact imaging technique used by ophthalmologists to assist in the evaluation and diagnosis of meibomian gland dysfunction (MGD). While artificial qualitative analysis of meibography images could lead to low repeatability and efficiency and multi-parametric analysis is demanding to offer more comprehensive information in ...
arxiv
Spatiotemporal Control Over Protein Release from Artificial Cells via a Light‐Activatable Protease
Advanced Biology, EarlyView.Stimulus‐responsive protein release is essential for intercellular communication. Mimicking this functionality in artificial cells is promising to study the working principles of cellular signaling. Herein, an engineered light‐activatable protease is implemented in a coacervate‐based artificial cell platform to establish user‐defined spatiotemporal ...
Arjan Hazegh Nikroo +4 more
wiley +1 more source
Advanced Biology, EarlyView.The manuscript examines preclinical murine and human models to study polycystic ovary syndrome (PCOS), delving into the cellular and molecular mechanisms underlying altered ovarian follicular dynamics. It explores the cellular interactions involved in normal and PCOS ovaries and outlines the current and novel strategies in the search for preclinical ...
Arturo Bevilacqua +5 more
wiley +1 more source
Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations
Advanced Functional Materials, EarlyView.Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan +4 more
wiley +1 more source
Endocrine dysregulation in COVID-19: molecular mechanisms and insights
Frontiers in EndocrinologyThis review describes the impact of COVID-19 on the endocrine system, focusing on cortisol signaling and growth factor-induced endocrine resistance. As expected, SARS-CoV-2 infection induces systemic inflammation, resulting in stimulation of the adrenal ...
Cristiana Iosef +9 more
doaj +1 more source
SYNDROME OF MULTIPLE ENDOCRINE NEOPLASIA OF TYPE 1: CLINICAL CASE
Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2019 Syndrome of multiple endocrine neoplasia of type 1 (MEN type 1, Vermer's syndrome) is a group of heterogeneous hereditary diseases whose pathogenesis is based on hyperplasia or tumoral transformation of several endocrine glands.
Gulinskaya O. V. +2 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray +2 more
wiley +1 more source
iScienceSummary: Our understanding and management of reproductive health and related disorders such as infertility, menstrual irregularities, and pituitary disorders depend on understanding the intricate sex-specific mechanisms governing prolactin secretion ...
Stanislav Cherepanov +7 more
doaj
DCAN: Deep Contour-Aware Networks for Accurate Gland Segmentation [PDF]
arXiv, 2016 The morphology of glands has been used routinely by pathologists to assess the malignancy degree of adenocarcinomas. Accurate segmentation of glands from histology images is a crucial step to obtain reliable morphological statistics for quantitative diagnosis.
arxiv