Results 151 to 160 of about 110,436 (285)

Molecular Cloning, Developmental Expression, and Phosphorylation of Ribosomal Protein S6 in the Endocrine Gland Responsible for Insect Molting [PDF]

, 1997
Qisheng Song, Lawrence I. Gilbert
openalex   +1 more source

TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition

Advanced Science, EarlyView.
This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang, Ende Wu, Weibin Liu, Ling Zeng, Neng Ling, Hongmei Wang, Zhixing Li, Shuang Yao, Tonghe Pan, Xuanwen Li, Yate Huang, Xiaojing Li, Yunhai Tu, Wentao Yan, Jianzhang Wu, Mao Ye, Wencan Wu   +16 more
wiley   +1 more source

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

44. The Study of the Response of the Endocrine System to the Brain-Trauma, Particularily on Hypothalamo-Hypophyseal System, Thyroid Gland and Adrenocortex under Hypothermic States

, 1962
Seiji ENDO, Kenshichiro Endo, Tetsuya Yamada, Yasuyuki Aisaka, Tsugio Akutsu, Masanori ONO, Fumiko Furukawa   +6 more
openalex   +2 more sources

Expression of Melanocortin-5 Receptor in Secretory Epithelia Supports a Functional Role in Exocrine and Endocrine Glands [PDF]

, 1998
M. van der Kraan
openalex   +1 more source

Vinburnine Sensitizes Radiotherapy Efficacy in Nasopharyngeal Carcinoma by Triggering Pyroptosis and Immune Responses via Activation of EDAR‐NFκB Pathway

Advanced Science, EarlyView.
This study demonstrates that vinburnine, an approved cerebrovascular drug, synergizes with radiotherapy in nasopharyngeal carcinoma (NPC) by modulating EDAR‐NFκB signaling through directly binding to EDAR, leading to triggering apoptosis/pyroptosis, and amplifying CCL5/CX3CL1‐driven T‐cell cytotoxicity.
Jing Chen, Nian Liu, Qian Tao, Jie Wu, Jinyu Huang, Can Lu, Qiuqiu Li, Liangfang Shen, Xiang Chen, Cong Peng   +9 more
wiley   +1 more source

NOTES ON THE POLYCYSTIC KIDNEY DISEASE IN THE GOLDFISH, WITH DESCRIPTION OF SOME OF THE ENDOCRINE GLANDS

, 1963
Yoshiharu Honma
openalex   +2 more sources

Targeted Delivery of CNS‐Specific Hesperidin as a Leptin Sensitizer for Treating Obesity‐Associated Sleep‐Disordered Breathing

Advanced Science, EarlyView.
Hesperidin nanoparticles (HE NPs) effectively combat obesity and sleep‐disordered breathing in mice by enhancing leptin sensitivity. Through suppression of hypothalamic endoplasmic reticulum stress and restoration of leptin signaling, HE NPs promote weight loss and improve breathing during sleep.
Yixuan Wang, Qingyu Zhao, Qingfeng Zhang, Xiaofeng Wu, Xu Liu, Shujuan Wu, Hailing Liu, Beini Zhou, Shiqian Zha, Dong Zhao, Gang Deng, Ke Hu   +11 more
wiley   +1 more source

ON THE FUNCTIONAL CORRELATION BETWEEN SALIVARY GLANDS AND OTHER ENDOCRINE ORGANS IV. THE EFFECT OF ANTITHYROID DRUGS ON THE THYMUS AND SALIVARY GLANDS OF THE RAT AND THE STUDY ON THE RELATION BETWEEN THESE TWO ORGANS

, 1961
Yosoji Ito, JUN KAWADA, MUNETSUGU KURATA
openalex   +2 more sources