Results 51 to 60 of about 449,258 (250)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

A rare case of multiple endocrine neoplasia type 1 initially presenting as an asymptomatic, huge mediastinal mass: case report

BMC Endocrine Disorders, 2021
Background Multiple endocrine neoplasia type 1 (MEN1) is a rare inherited syndrome that concurrently involves various endocrine glands. We report a rare case of MEN1 in a 43-year-old man whose first manifestation was an asymptomatic mediastinal mass ...
Ji Eun Jun, You-Cheol Hwang, Kyu Jeong Ahn, Ho Yeon Chung, In-Kyung Jeong   +4 more
doaj   +1 more source

Amyotrophic lateral sclerosis (ALS) and the endocrine system: Are there any further ties to be explored?

Aging Brain, 2021
Amyotrophic Lateral Sclerosis (ALS) belongs to the family of neurodegenerative disorders and is classified as fronto-temporal dementia (FTD), progressive muscular atrophy, primary lateral sclerosis, and pseudobulbar palsy.
Alexios-Fotios A. Mentis, Anastasia M. Bougea, George P. Chrousos   +2 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Multimodality appearance of multiple endocrine neoplasia type 1: A case report

Radiology Case Reports, 2019
Multiple endocrine neoplasia type 1 is a rare autosomal dominant disorder classically characterized by a predisposition to tumors of the parathyroid glands, anterior pituitary, and enteropancreatic endocrine cells.
John Monge, MD, Daniel Homuth, DO, Loren Zuiderveld, MD   +2 more
doaj   +1 more source

Effects of bisphenol A on murine salivary glands and human tumor cell lines

Experimental and Molecular Pathology, 2023
Bisphenol A (BPA) is an endocrine-disrupting chemical with a potential role in endocrine cancers. However, the effects of BPA on the salivary glands have been barely explored.
Gabriela Kelly da Silva, José Alcides Almeida de Arruda, Tatiana Fernandes Araújo Almeida, Sicília Rezende Oliveira, Paula Alves da Silva Rocha, Ricardo Alves Mesquita, Zenilda de Lourdes Cardeal, Helvécio Costa Menezes, Ivana Márcia Alves Diniz, Soraia Macari, Andréia Machado Leopoldino, Tarcília Aparecida Silva   +11 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Endocrine gland size is proportional to its target tissue size

iScience
Summary: Endocrine glands secrete hormones into the circulation to target distant tissues and regulate their functions. The qualitative relationship between hormone-secreting organs and their target tissues is well established, but a quantitative ...
Moriya Raz, Tomer Milo, David S. Glass, Avi Mayo, Uri Alon   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Preliminary investigation reveals novel pathological consequences of bluetongue virus-1 infection in the endocrine glands of pregnant Indian sheep

Animal Biotechnology
Bluetongue virus (BTV), a major peril to the sheep industry, infects a wide range of the cells in the infected animals including mononuclear, dendritic and epithelial cells. However, little is known about its tropism for the secretory epithelial cells of
Rohit Singh, Karam Pal Singh, Rajendra Singh, Vidya Singh, Pawan Kumar, Rajat Varshney, Akanksha Yadav, Akash Mote, Mukesh Gangwar, N. Babu Prasath   +9 more
doaj   +1 more source