Results 121 to 130 of about 368,686 (349)

Timing and Predictive Value of Clinical Conditions Preceding Multiple Sclerosis in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Multiple sclerosis (MS) patients often experience a higher incidence of clinical conditions before diagnosis, suggesting a prodromal phase. However, their predictive value and temporal trajectories remain underexplored. We investigated these aspects using the large UK Biobank's population‐based cohort, which provided clinical ...
Andrea Nova, Teresa Fazia, Giovanni Di Caprio, Davide Gentilini, Luisa Bernardinelli, Roberto Bergamaschi   +5 more
wiley   +1 more source

Riscos cardiovasculares do bloqueio androgênico Riesgos cardiovasculares del bloqueo androgénico Cardiovascular risks of androgen deprivation therapy

Arquivos Brasileiros de Cardiologia, 2010
O adenocarcinoma de próstata é o câncer mais comum no sexo masculino após o câncer de pele. Entre as várias formas de tratamento do câncer de próstata, a terapia de bloqueio androgênico é uma modalidade consagrada nos pacientes com doença metastática ou ...
Adriano Freitas Ribeiro, César Camara, Carlos Alexandre Segre, Miguel Srougi, Carlos V. Serrano Jr   +4 more
doaj   +1 more source

Effects of Pharmacologic and Nonpharmacologic Interventions for the Management of Sleep Problems in People With Fibromyalgia: Systematic Review and Network Meta‐Analysis of Randomized Controlled Trials

Arthritis Care &Research, EarlyView.
Objective Fibromyalgia is a chronic condition characterized by widespread musculoskeletal pain and fatigue. Almost everyone with fibromyalgia has sleep problems. We aimed to evaluate the effectiveness and safety of current interventions for the management of fibromyalgia‐related sleep problems.
Jemma Hudson, Mari Imamura, Clare Robertson, Daniel Whibley, Lorna Aucott, Katie Gillies, Paul Manson, Debra Dulake, Abhishek Abhishek, Nicole K. Y. Tang, Gary J. Macfarlane, Miriam Brazzelli   +11 more
wiley   +1 more source

Steroid profiling in male wobbler mouse, a model of Amyotrophic Lateral Sclerosis [PDF]

, 2016
The Wobbler mouse is an animal model for human motoneuron diseases, especially amyotrophic lateral sclerosis (ALS), used in the investigation of both pathology and therapeutic treatment.
Aprahamian, Fanny, Cambourg, Annie, de Nicola, Alejandro Federico, Di Giorgio, Noelia Paula, Gonzalez Deniselle, Maria Claudia, Guennoun, Rachida, Liere, Philippe, Meyer, Maria, Pianos, Antoine, Schumacher, Michael   +9 more
core   +1 more source

Retrotransposon Expression Is Upregulated in Adulthood and Suppressed during Regeneration of the Limb in the Axolotl (Ambystoma mexicanum)

Advanced Biology, EarlyView.
The axolotl's remarkable regenerative abilities decline with age, the causes may include the numerous repetitive elements within its genome. This study uncovers how Ty3 retrotransposons and coexpression networks involving muscle and immune pathways respond to aging and regeneration, suggesting that transposons respond to physiological shifts and may ...
Samuel Ruiz‐Pérez, Nicolás Alcaraz, Karla Torres‐Arciga, José Antonio Ocampo‐Cervantes, Alejandra Cervera, Clementina Castro‐Hernández, Cynthia Gabriela Sámano‐Salazar, Ernesto Soto‐Reyes, Rodrigo González‐Barrios   +8 more
wiley   +1 more source

A network biology-based approach to evaluating the effect of environmental contaminants on human interactome and diseases

, 2018
Environmental contaminant exposure can pose significant risks to human health. Therefore, evaluating the impact of this exposure is of great importance; however, it is often difficult because both the molecular mechanism of disease and the mode of action
Iida, Midori, Takemoto, Kazuhiro
core   +1 more source

Frequency and Risk Factors of Endocrine Complications in Turkish Children and Adolescents with Sickle Cell Anemia

Turkish Journal of Hematology, 2013
Objective: To define frequency and risk factors of abnormalities in growth, puberty, thyroid function, and bone and carbohydrate metabolisms in children and adolescents with sickle cell disease (SCD). Materials and Methods: Endocrine problems including
Samim Özen, Selma Ünal, Neslihan Erçetin, Bahar Taşdelen   +3 more
doaj   +1 more source

Retrospective analysis of the incidence rate of the population in the Republic of Tatarstan with diseases of the endocrine system

, 2022
Oksana A. Frolova, Tafeeva Ea, D. N. Frolov, E. Kh. Yangirova   +3 more
openalex   +2 more sources

Murine Models and Human Cell Line Models to Study Altered Dynamics of Ovarian Follicles in Polycystic Ovary Syndrome

Advanced Biology, EarlyView.
The manuscript examines preclinical murine and human models to study polycystic ovary syndrome (PCOS), delving into the cellular and molecular mechanisms underlying altered ovarian follicular dynamics. It explores the cellular interactions involved in normal and PCOS ovaries and outlines the current and novel strategies in the search for preclinical ...
Arturo Bevilacqua, Cristiano Giuliani, Giovanna Di Emidio, Samuel H Myers, Vittorio Unfer, Carla Tatone   +5 more
wiley   +1 more source

Fecal Microbiota Transplantation Modulates Th17/Treg Balance via JAK/STAT Pathway in ARDS Rats

Advanced Biology, EarlyView.
Fecal microbiota transplantation (FMT) alleviates lung and intestinal injury in lipopolysaccharide (LPS)‐induced acute respiratory distress syndrome (ARDS) in rats. This study demonstrates that FMT restores the balance between Th17 and Treg cells, inhibits the JAK/STAT pathway, and modulates cytokine levels, reducing inflammation and lung damage. These
Dongwei Zhang, Biying Dong, Jie Chen, Zhenqiang Zhang, Weitong Zeng, Longxiong Liao, Xia Xiong, Xuejun Qin, Xianming Fan   +8 more
wiley   +1 more source