Results 121 to 130 of about 2,258,907 (387)
Turkish Journal of Hematology, 2013 Objective: To define frequency and risk factors of abnormalities in growth, puberty, thyroid function, and bone and carbohydrate metabolisms in children and adolescents with sickle cell disease (SCD). Materials and Methods: Endocrine problems including
Samim Özen +3 more
doaj +1 more source
Environmental chemical exposures and breast cancer [PDF]
, 2016 As a hormone-sensitive condition with no single identifiable cause, breast cancer is a major health problem. It is characterized by a wide range of contributing factors and exposures occurring in different combinations and strengths across a lifetime ...
Plant, J, Stanley, E, Voulvoulis, N
core +2 more sources
FEBS Open Bio, EarlyView.Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy +14 more
wiley +1 more source
Evidence for a GABAergic system in rodent and human testis: Local GABA production and GABA receptors [PDF]
, 2003 The major neurotransmitter of the central nervous system, gamma-aminobutyric acid (GABA), exerts its actions through GABA(A), GABA(B) and GABA(C) receptors.
Calandra, Ricardo S. +7 more
core +2 more sources
American Journal of Clinical Nutrition, 2008 New knowledge of the biological and clinical importance of the steroid hormone 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)] and its receptor, the vitamin D receptor (VDR), has resulted in significant contributions to good bone health.
A. Norman
semanticscholar +1 more source
FEBS Open Bio, EarlyView.We investigated a potential protective effect of acacetin, a naturally occurring flavonoid, against methylglyoxal (MGO)‐induced endothelial dysfunction in human umbilical vein endothelial cells and its mechanism of action. Acacetin can could inhibit MGO‐induced intracellular calcium ion influx, enhance the expression levels of phosphorylated ...
Zhen Zhang +7 more
wiley +1 more source
Vitamin D: Newer Concepts of Its Metabolism and Function at the Basic and Clinical Level. [PDF]
, 2020 The interest in vitamin D continues unabated with thousands of publications contributing to a vast and growing literature each year. It is widely recognized that the vitamin D receptor (VDR) and the enzymes that metabolize vitamin D are found in many ...
Bikle, Daniel D
core +1 more source
FEBS Open Bio, EarlyView.The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli +15 more
wiley +1 more source
Functional Evidence of CCDC186 as a New Disease Associated Gene with Endocrine and Central Nervous System Alterations [PDF]
, 2023 Luisa Arrabal +7 more
openalex +2 more sources
Bayesian nonparametric inference for the covariate-adjusted ROC curve [PDF]
arXiv, 2018 Accurate diagnosis of disease is of fundamental importance in clinical practice and medical research. Before a medical diagnostic test is routinely used in practice, its ability to distinguish between diseased and nondiseased states must be rigorously assessed through statistical analysis.
arxiv