Results 291 to 300 of about 1,713,173 (369)

Elemene Augments the Effects of Anti‐PD‐1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR‐130a‐5p/SPP/MHC‐I Axis

Advanced Science, EarlyView.
Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang, Mengqing Sun, Heng Dong, Xiaoting Zhang, Jingbo Zhang, Zhengguo Zhang, Mengjie Ni, Lina Li, Yunxin Pei, Xiaoyu Chen, Qian Li, Fangtian Bu, Jiacheng Huang, Liangyu Jiang, Zhuting Fang, Xuliang Chen, Jianxiang Chen, Yiting Qiao, Tian Xie   +18 more
wiley   +1 more source

EndoCompass Project: Artificial Intelligence in Endocrinology.

Horm Res Paediatr
Assié G, Carneiro G, Davies E, Šojat AS, Mertens J.   +4 more
europepmc   +1 more source

Endocrine polyautoimmunity: Mechanistic insights and the future of AI-driven diagnostics. [PDF]

EXCLI J
Heydarzadeh S, Abooshahab R, Zarkesh M, Hedayati M.   +3 more
europepmc   +1 more source

Lipid‐Driven OLR1/FOXM1/FGF19 Axis Orchestrates Crosstalk in an Epithelial‐Fibroblast Positive Feedback Promoting Progesterone Resistance in Endometrial Cancer

Advanced Science, EarlyView.
It is revealed that a metabolic–stromal loop driven by oxLDL–OLR1–FOXM1–FGF19 signaling promotes progesterone resistance in endometrial cancer. OxLDL activates epithelial–fibroblast crosstalk, enhancing proliferation and hormonal insensitivity. Disruption of this circuit, especially with resveratrol, restores MPA sensitivity, highlighting a potential ...
Xingchen Li, Yue Qi, Yuman Wu, Xinyi Bi, Yiqin Wang, Jiaqi Wang, Jingyuan Wang, Lingpu Zhang, Haihua Xiao, Jianliu Wang   +9 more
wiley   +1 more source

The emerging science of psycho-neuro-endocrine-immunology and glaucoma management. [PDF]

Indian J Ophthalmol
Dada T.
europepmc   +1 more source

FSTL1 Orchestrates Metabolic‐Epigenetic Crosstalk: Glycolysis‐Dependent H3K18 Lactylation Drives Cartilage Fibrosis in Osteoarthritis

Advanced Science, EarlyView.
FSTL1 promotes glycolysis during chondrocyte fibrosis by triggering the HIF‐1 signaling pathway, which causes lactate to accumulate. The buildup of lactate leads to changes in histone lysine lactylation, which in turn enhances the expression of genes associated with fibrosis.
Feng Lu, Yunyuan Yu, Guangrong Yin, Huiqun Hu, Shishuo Li, Yuting Tang, Yimin Liu, Maoyuan Li, Liang liang Wang, Chao Xu, Gongyin Zhao, Baojun Zhou, Yuji Wang   +12 more
wiley   +1 more source

Unraveling life expectancy and death spectrum changes of registered residents (hukou) in Quzhou, China, 2015-2023: a study using Arriaga decomposition method. [PDF]

Front Public Health
Pan J, Huang Y, Jiao S, Zheng B, Yin Z, Gan Z.   +5 more
europepmc   +1 more source

Criteria for development of animal models of diseases of the endocrine system.

, 1980
Capen Cc
openalex   +1 more source

Epipharyngeal Abrasive Therapy (EAT) Field Theory: A Clinical Framework for EAT in Modulating Psycho-Neuro-Endocrino-Immune (PNEI) Dynamics. [PDF]

Cureus
Hirobumi I.
europepmc   +1 more source

Impact of comorbidities on survival in melanoma patients. [PDF]

BMC Cancer
Buja A, Cassalia F, Rugge M, Trevisiol C, Zorzi M, Del Fiore P, Pantaleo I, Rossi CR, Conte P, Belloni Fortina A, Mocellin S.   +10 more
europepmc   +1 more source