Physical activity and hypocaloric diet recovers osteoblasts homeostasis in women affected by abdominal obesity. [PDF]
, 2016 Obesity is a multifactorial disease linked to metabolic chronic disorders such as diabetes, and hypertension. Also, it has recently been associated with skeletal alterations and low bone mineral density.
Baldari, C +13 more
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Encountering COVID-19 as Endocrinologists [PDF]
Endocrinology and Metabolism, 2020 The world is entering an era of disaster and chaos due to coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2. Since its first emergence in December 2019 in Wuhan, China, COVID-19 has swept through Asia
Eun-Jung Rhee +3 more
doaj +1 more source
Endocrine FGFs: evolution, physiology, pathophysiology, and pharmacotherapy
Frontiers in Endocrinology, 2015 The human fibroblast growth factor (FGF) family comprises 22 structurally related polypeptides that play crucial roles in neuronal functions, development, and metabolism.
Nobuyuki eItoh +2 more
doaj +1 more source
Risk factors associated with the occurrence of autoimmune diseases in adult coeliac patients [PDF]
, 2018 Objectives. Autoimmune diseases (AD) may be associated with coeliac disease (CD), but specific risk factors have been poorly investigated. The aim of this study was to assess the spectrum of AD and its specific risk factors associated in a series of ...
Annibale, Bruno +5 more
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Modulation of PC1/3 activity by a rare double-site homozygous mutation
Frontiers in Pediatrics, 2022 ObjectivesPreprotein convertase 1/3 deficiency is a rare autosomal recessive disorder in which patients present with malabsorptive diarrhea and a series of symptoms of endocrine disorders such as polydipsia, reactive hypoglycemia, growth hormone ...
Yanyan Ni +5 more
doaj +1 more source
Cyclic nucleotide signaling as a drug target in retinitis pigmentosa
FEBS Letters, EarlyView.Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää +2 more
wiley +1 more source
Myxedema coma presenting with seizures, pericardial effusion, and rhabdomyolysis
Iatreia, 2021 Myxedema coma is the most serious complication of hypothyroidism. It usually occurs in the context of elderly women, with known hypothyroidism without proper management and in the presence of a triggering event.
Juan Sebastián Peinado-Acevedo +3 more
doaj +1 more source
Serum thyroid hormone antibodies are frequent in patients with polyglandular autoimmune syndrome type 3, particularly in those who require thyroxine treatment [PDF]
, 2017 Polyglandular autoimmune syndrome (PAS) type 3 consists of autoimmune thyroid disease (AITD) coexisting with ≥1 non-thyroidal autoimmune disease (NTAID) other than Addison’s disease and hypoparathyroidism. We evaluated the prevalence and repertoire of
Benvenga, Salvatore +8 more
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Molecular Oncology, EarlyView.Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane +16 more
wiley +1 more source
Role of psychosocial stress in complex diseases [PDF]
, 2012 peer reviewedComplex diseases are chronic diseases where the interrelations between genetic predisposition and environmental factors play an essential role in the arisen and the maintenance of the pathology.
Scantamburlo, Gabrielle, SCHEEN, André
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