Results 141 to 150 of about 255,642 (262)

Circulating tumor DNA in neoadjuvant endocrine therapy for early breast cancer. [PDF]

ESMO Open
Grinshpun A, Dustin D, Cai M, Hughes M, DiLullo M, Moore M, Yardley D, Mayer IA, Symmans WF, Mayer EL, Winer EP, Lin NU, Tolaney SM, Metzger O, Jeselsohn R.   +14 more
europepmc   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Role of HER2 in Response to Neoadjuvant Endocrine Therapy in Luminal Breast Cancer. [PDF]

Curr Oncol
Monte CD, Martí C, Rodríguez E, Moreno-Palacios E, Frías L, Meléndez M, Loayza A, Yébenes L, Sánchez-Méndez JI.   +8 more
europepmc   +1 more source

Covalent Inhibition of SHMT2 by Gambogic Acid Induces Ferroptosis Through Mitochondrial Collapse in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In this study, chemoproteomics combined with genetic and functional analyses was integrated to identify SHMT2 as a covalent and functional target of gambogic acid (GA) in triple‐negative breast cancer (TNBC). Further validation demonstrated that GA selectively modifies the Cys241 site of SHMT2, triggering mitochondrial dysfunction, activating the Nrf2 ...
Tong Yang, Chong Qiu, Yulei Li, Ying Zhang, Chen Wang, Jie Zhou, Zheng Chu, Ang Ma, Ling Huang, Yin Kwan Wong, Junzhe Zhang, Peng Gao, Cui Liu, Junhua Zhang, Huan Tang, Jigang Wang   +15 more
wiley   +1 more source

Chinese expert consensus on endocrine therapy for breast cancer (2026 edition). [PDF]

Transl Breast Cancer Res
Yuan Y, Yin Y, Wang S, Liu Y, Yang J, Yan M, Mo X, Pan Y, Wang X, Wang H, Li J, Wang S, Wu J, Song E, Jiang Z, Chinese Consensus Group on Breast Cancer Endocrine Therapy.   +15 more
europepmc   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Extended Endocrine Therapy and Survival for Breast Cancer Subtypes in Premenopausal Patients.

JAMA Netw Open
Valenza C, Zheng Y, Milano M, Berton Giachetti PPM, Trapani D, Giordano E, Guidi L, Boldrini L, Castellano G, Katrini J, Malagutti B, Antonarelli G, Etessami JD, Bianco N, Conforti F, Kirkner GJ, Sangalli C, Dibble KE, Fusco N, Colleoni M, Regan MM, Munzone E, Curigliano G, Partridge AH.   +23 more
europepmc   +1 more source

Endocrine therapy and COVID-19 outcomes in women with breast cancer: a nationwide register- based matched cohort study. [PDF]

BMC Cancer
Schiza A, Digkas E, Papadopoulos F, Skalkidou A, Elenis E.   +4 more
europepmc   +1 more source

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

Endocrine therapy reprogramming of breast cancer facilitates metastatic escape via upregulation of P-Rex1/Rac1 signalling. [PDF]

Nat Commun
Fernandez KJ, Sultani G, Nobis M, Gloss B, Eshraghi L, McCart Reed AE, Alexandrou S, Lee C, Roden DL, Jones EI, Simad MH, Millar EKA, Bartonicek N, Oakes SR, Valdes-Mora F, Colino-Sanguino Y, Mok ETY, Williams HL, Kutasovic JR, Cummings MC, Stoehr J, Lee V, Harvey K, Wu S, Lakhani SR, Simpson PT, Cox TR, Ooms LM, Mitchell CA, Salomon R, Swarbrick A, Gallego-Ortega D, Lim E, Timpson P, Caldon CE.   +34 more
europepmc   +1 more source