Results 201 to 210 of about 466,117 (305)

Primary endocrine therapy versus surgery plus endocrine therapy for early-stage breast cancer in older women without frailty: a cost-effectiveness and value of implementation analysis. [PDF]

Health Econ Rev
Wang Y, Chen LC, Cheung KL, Steinke D, Gavan SP.   +4 more
europepmc   +1 more source

Engineered Microfluidic Organoid Systems: New Paradigms for Menopause Mechanism Research and Personalized Medicine

Advanced Materials Technologies, EarlyView.
This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang, He Huang, Hongliang Dong, Qiang Ma, Hongyan Jin   +4 more
wiley   +1 more source

Predictive value of peripheral blood immune markers for castration-resistant prostate cancer development after endocrine therapy. [PDF]

Front Oncol
Li F, Cui L, Zhang G, Hao J.
europepmc   +1 more source

Mapping of Physiological Signals From Wireless Battery‐Free Implants With Plane‐Wave Ultrasound Imaging

Advanced Materials Technologies, EarlyView.
Combined approach of electromagnetic (Power) and ultrasound (data harvesting) waves is proposed to address the miniaturized ultrasonic implants. Electromagnetic waves trigger the piezoelectric element to generate the acoustic pulse which is modulated by the variations in the sensor's impedance.
Anam Bhatti, Hugo Guillot, Ouafae Firdaouissi, Mohammed Irar, Lionel Rousseau, Clément Hébert, Maxime Lafond   +6 more
wiley   +1 more source

Optimizing adjuvant endocrine therapy in premenopausal patients with HER2-positive, hormone receptor-positive breast cancer. [PDF]

Breast
Valenza C, Partridge AH, Regan MM.
europepmc   +1 more source

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

CD8+ T cells in the tumor microenvironment modulate the response to endocrine therapy in breast cancer. [PDF]

J Clin Invest
Napolitano F, Wang Y, Sudhan DR, Gonzalez-Ericsson PI, Formisano L, Unni N, Shakeel S, Zhu JZ, Ahuja K, Guo L, Chica-Parrado MR, Matsunaga Y, Luna P, Lin CA, Uemoto Y, Lee KM, Ma H, Evans NJ, Servetto A, Mendiratta S, Barnes SD, Bianco R, Fang YV, Xu L, Lee J, Wang T, Balko JM, Mills GB, Labrie M, Hanker AB, Arteaga CL.   +30 more
europepmc   +1 more source

ELABELA Targets Mitochondria to Modulate Heart Development

Advanced Science, EarlyView.
The role of peptide ELABELA (ELA) in cardiomyocyte apoptosis and congenital heart disease (CHD) is unclear. ELA deficiency caused cardiomyocyte apoptosis and CHD. A novel ELA‐APJ‐AKT‐BCL2/BAX axis in regulating mitochondrial function and contributing to CHD pathogenesis was established.
Jian Wang, Qingjie Wang, Zhikang Xu, Shuang Zhou, Yue Zhou, Junjie Yang, Lingfeng Tong, Zhuo Meng, Mei Yang, Wen Zhao, Tie Yang, Hualin Wang, Jun Zhang, Rubin Tan, Lei Wang, Yuqiang Huang, Bin Zhou, Sun Chen, Bing Zhang, Jinxiang Yuan, Jianyuan Zhao, Alex F. Chen, Kun Sun   +22 more
wiley   +1 more source

Thyroid dysfunction in African trypanosomiasis [PDF]

, 1993
Allolio, B., Arlt, W., Chrousos, G. P., Heppner, C., Mbulamberi, D., Petzke, F., Reincke, Martin, Siekmann, L., Vollmer, D., Winkelmann, W.   +9 more
core  

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

Advanced Science, EarlyView.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu, Yanzhi Feng, Qingqing Zhu, Ting Jiang, Yueyue Gao, Kebing Nie, Xianan Tang, Ying Chen, Dianxing Hu, Xudan Yang, Shixuan Wang, Meng Wu, Jinjin Zhang   +12 more
wiley   +1 more source