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Mediation Analysis using Semi-parametric Shape-Restricted Regression with Applications [PDF]
Often linear regression is used to perform mediation analysis. However, in many instances, the underlying relationships may not be linear, as in the case of placental-fetal hormones and fetal development. Although, the exact functional form of the relationship may be unknown, one may hypothesize the general shape of the relationship. For these reasons,
arxiv
DynPeak : An algorithm for pulse detection and frequency analysis in hormonal time series [PDF]
The endocrine control of the reproductive function is often studied from the analysis of luteinizing hormone (LH) pulsatile secretion by the pituitary gland. Whereas measurements in the cavernous sinus cumulate anatomical and technical difficulties, LH levels can be easily assessed from jugular blood.
arxiv +1 more source
Historical aspects of endocrinology development
The historical data on the development of medicine as a science, with an emphasis on aspects of the endocrinology, are given in this paper. The role of Ukrainian and foreign scientists and their contribution to the development of the chemistry of ...
M.D. Tronko, Ya.H. Balon, O.Ya. Samson
doaj +1 more source
Transition of young adults with endocrine and metabolic diseases: the ‘TRANSEND’ cohort
Objective: The transition from paediatric to adult medicine involves risks of poor patient outcomes and of significant losses of patients to follow up. The research aimed to analyse the implementation in an initial cohort of patients of a new programme ...
Enora Le Roux+12 more
doaj +1 more source
Profiling of FSHR Negative Allosteric Modulators on LH/CGR Reveals Biased Antagonism with Implications in Steroidogenesis [PDF]
Biased signaling has recently emerged as an interesting mean to modulate the function of many G protein-coupled receptors (GPCRs). Previous studies reported two negative allosteric modulators (NAMs) of follicle-stimulating hormone receptor (FSHR), ADX68692 and ADX68693, with differential effects on FSHR-mediated steroidogenesis and ovulation.
arxiv +1 more source
Risk of osteoporosis in testicular germ cell tumour survivors: A systematic review of the literature
Abstract Context Testicular germ cell tumour (TGCT) survivors are potentially at risk of developing osteoporosis, because of increased risk for disturbed bone remodelling associated with hypogonadism and anti‐cancer treatment. A number of studies show bone loss and increased fracture risk in TGCT survivors, but data are scarce.
Josephina P. M. Vrouwe+4 more
wiley +1 more source
Case Report: Ovulation Induction in Greater One-Horned Rhinoceros (Rhinoceros unicornis)
Despite a profound knowledge on reproduction biology in greater one-horned (GOH) rhinoceros, many individuals cope with sub or infertility or an-ovulatory estrous.
Robert Hermes+5 more
doaj +1 more source
Background Unbalanced translocations between the q arm of chromosomes 5 and 13 are exceedingly rare and there is only one reported case with distal trisomy 5q/monosomy 13q. In this report, we describe a second patient with a similar rearrangement arising
Alyssa C. M. Joynt+5 more
doaj +1 more source
ENDOCRINOLOGY IN THE TIME OF COVID-19: Management of adrenal insufficiency
We provide guidance on prevention of adrenal crisis during the global COVID-19 crisis, a time with frequently restricted access to the usual level of healthcare.
W. Arlt+3 more
semanticscholar +1 more source
The American Association of Clinical Endocrinologists/American College of Endocrinology Medical Guidelines for Clinical Practice are systematically developed statements to assist healthcare professionals in medical decision making for specific clinical ...
Y. Handelsman+33 more
semanticscholar +1 more source