Results 71 to 80 of about 784,305 (383)

Gut Microbiota Modulates Obesity‐Associated Skeletal Deterioration Through Macrophage Aging and Grancalcin Secretion

Advanced Science, EarlyView.
Obese gut‐microbiota derived lipopolysaccharides (LPS) induce bone marrow macrophage senescence and GCA secretion via activating TLR4/NF‐κB/MAPKs pathway. Clinically, obese patients are associated with higher serum GCA levels. Mice with depletion of GCA gene show resistance to skeletal deterioration caused by obesity and LPS‐induced chronic ...
Min Huang, Mei Huang, Ling Liu, Fang Yang, Chen He, Yu‐Chen Sun, Yu‐Rui Jiao, Xiang Tang, Jing Hou, Kai‐Xuan Chen, Wen‐Zhen He, Jie Wei, Hui‐Ling Chen, Xia Li, Chao Zeng, Guang‐Hua Lei, Chang‐Jun Li   +16 more
wiley   +1 more source

Absent Exercise-Induced Improvements in Fat Oxidation in Women With Polycystic Ovary Syndrome After High-Intensity Interval Training

Frontiers in Physiology, 2021
Background: Polycystic ovary syndrome (PCOS) and metabolic inflexibility are linked to insulin resistance, and women with PCOS appear to be metabolic inflexible in the rested, insulin-stimulated state.
Sofie Lionett, Sofie Lionett, Ida Almenning Kiel, Ida Almenning Kiel, Ragnhild Røsbjørgen, Stian Lydersen, Steen Larsen, Steen Larsen, Trine Moholdt, Trine Moholdt   +9 more
doaj   +1 more source

Endocrinology of hirsutism

International Journal of Trichology, 2010
Hirsutism represents a primary clinical indicator of androgen excess. The most common endocrine condition causing hirsutism is polycystic ovary syndrome (PCOS). Diagnosing PCOS is not easy as the signs and symptoms are heterogenous. The newest diagnostic guideline made by the Androgen Excess and PCOS Society in 2006, claims the presence of ...
Daisy Kopera, Barbara Obermayer-Pietsch, Elisabeth Wehr   +2 more
openaire   +4 more sources

Methylation status of Vitamin D receptor gene promoter in benign and malignant adrenal tumors [PDF]

, 2015
We previously showed a decreased expression of vitamin D receptor (VDR) mRNA/protein in a small group of adrenocortical carcinoma (ACC) tissues, suggesting the loss of a protective role of VDR against malignant cell growth in this cancer type ...
Cappellesso, Rocco, Fallo, Francesco, Fassina, Ambrogio, Guzzardo, Vincenza, Pilon, Catia, Rebellato, Andrea, Sasano, Hironobu, Urbanet, Riccardo   +7 more
core   +4 more sources

Klinefelter Syndrome: Integrating Genetics, Neuropsychology, and Endocrinology.

Endocrine reviews, 2018
Although first identified over 70 years ago, Klinefelter syndrome (KS) continues to pose substantial diagnostic challenges, as many patients are still misdiagnosed, or remain undiagnosed.
C. Gravholt, Simon Chang, M. Wallentin, J. Fedder, P. Moore, A. Skakkebæk   +5 more
semanticscholar   +1 more source

Multiscale Organization of Neural Networks in a 3D Bioprinted Matrix

Advanced Science, EarlyView.
A 3D bioprint model of primary neurons has been engineered with a millimeter‐scale functional neural network, and it recapitulates in vivo transcriptomic features under both normal and disease conditions to the greatest extent. The successful integration of mature neurons and 3D bioprinting signifies a major advance in neuroscience modeling ...
Huiyu Yang, Jiangang Zhang, Yiran Li, Zihan Zhong, Wenhua Li, Haojun Luo, Yanyong Liu, Liujian Ouyang, Zhuoran Jiang, Yuning Sun, Hang Sun, Lulu Liu, Huayu Yang, Yu Wang, Nan Yang, Wenbin Ma, Yilei Mao   +16 more
wiley   +1 more source

Ergonomic endocrinology

Journal of the Pakistan Medical Association
In this opinion piece, we introduce the concept of ergonomic endocrinology. Ergonomic endocrinology is defined as the bidirectional and multifaceted relationship between endocrine health and dysfunction on one hand, and ergonomic design and engineering ...
Sanjay Kalra, Atul Dhingra, Nitin Kapoor
doaj   +1 more source

Heterogeneous circulating miRNA profiles of PBMAH

Frontiers in Endocrinology, 2022
ObjectivePrimary bilateral macronodular adrenal hyperplasia (PBMAH), a rare cause of Cushing syndrome, is often diagnosed as a bilateral adrenal incidentaloma with subclinical cortisol production.
Kazunari Hara, Masanori Murakami, Yoshihiro Niitsu, Akira Takeuchi, Masato Horino, Kumiko Shiba, Kumiko Shiba, Kazutaka Tsujimoto, Chikara Komiya, Kenji Ikeda, Mika Tsuiki, Akiyo Tanabe, Toshihiro Tanaka, Toshihiro Tanaka, Minato Yokoyama, Yasuhisa Fujii, Mitsuhide Naruse, Mitsuhide Naruse, Tetsuya Yamada   +18 more
doaj   +1 more source

Reproductive tract biology: Of mice and men. [PDF]

, 2019
The study of male and female reproductive tract development requires expertise in two separate disciplines, developmental biology and endocrinology.
Baskin, Laurence S, Cao, Mei, Cunha, Gerald R, Ricke, Will A, Robboy, Stanley J, Sinclair, Adriane   +5 more
core  

Severe loss-of-function mutations in the adrenocorticotropin receptor (ACTHR, MC2R) can be found in patients diagnosed with salt-losing adrenal hypoplasia [PDF]

, 2006
Objective: Familial glucocorticoid deficiency type I (FGD1) is a rare form of primary adrenal insufficiency resulting from recessive mutations in the ACTH receptor (MC2R, MC2R).
Achermann, JC, Al-Ali, M, Alzyoud, M, Brain, CE, Clark, AJ, Dattani, MT, Hindmarsh, PC, Lin, L, Metherell, LA   +8 more
core   +2 more sources