Results 81 to 90 of about 1,780,146 (263)

Dual Labor Market and Endogenous Fluctuations [PDF]

We study the influence of wage differential on the emergence of endogenous fluctuations. In this way, we introduce a dual labor market, based on the Shapiro-Stiglitz efficiency wage theory in an overlapping generations model. We show that wage inequality
Thomas Seegmuller, Francesco De Palma
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Antioxidant Potentials and Nephroprotective Effects of Methanol Extract and Dichloromethane Fraction of Root Bark of Garcinia kola (Heckel) on Gentamicin-Induced Nephrotoxic Rats

UMYU Scientifica Journal
This study investigated the nephroprotective and antioxidant effects of methanol extract (ME) and dichloromethane fraction (DCMF) from the root bark of Garcinia kola against gentamicin-induced nephrotoxicity in rats.
Ige Joseph Komolafe, Adeniyi Oluwadare Fajobi, Christianah Adebimpe Dare, Adetoun Elizabeth Morakinyo, Mukaila Babatunde Adekola, Oludele Olayemi Odekanyin, Oluokun Oluboade Oyedapo   +6 more
doaj   +1 more source

On Taxation in a Two-Sector Endogenous Growth Model with Endogenous Labor Supply [PDF]

This paper studies the effects of taxation on long-run growth in a two-sector endogenous growth model with (i) physical capital as an input in the education sector and (ii) leisure as an additional argument in the utility function. Due to the flexibility
Paul A. de Hek
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

STEA-Net: An Endogenous Multi-Pollutant-Driven Spatio-Temporal Framework for Urban PM_2.5 Forecasting

Applied Sciences
Elevated concentrations of fine particulate matter (PM2.5) are a critical threat to respiratory health worldwide. Therefore, there is an urgent need for precise urban forecasting systems for public health management.
Surleen Kaur, Sandeep Sharma
doaj   +1 more source

Fertility Choices, Human Capital Accumulation, and Endogenous Volatility [PDF]

In a three-period overlapping generations model, I show that different combinations of preference and technological parameters can lead to different patterns on the joint evolution of human capital and (endogenous) fertility choices.
Dimitrios Varvarigos
core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Money, Endogenous Fertility and Economic Growth

, 2003
This paper analyzes the issue of money superneutrality through an intertemporal optimizing model of capital accumulation with endogenous fertility, i.e. endogenous population growth.
Alberto Petrucci, Facoltà Di Economia, Money Endogenous Fertility   +2 more
core  

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source