Results 61 to 70 of about 6,104,063 (260)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Endogenous business cycles and growth [PDF]
Current explanations why a growing economy necessarily goes through booms and recessions predict countercyclical R&D investment. As this is very controversial from an empirical perspective, a stochastic Poissonmodel of endogenous business cycles and ...
Wälde, Klaus
core
European Journal of Government and Economics, 2016 The European Union has experienced weak economic performance over the past 15 years, compared to the United States. In order to restore investment, innovation, and therefore growth, the European Commission seeks to raise the level of static competition ...
Stephane Ciriani, Marc Lebourges
doaj
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Exogenous vs Endogenous Growth in the EU’s EaP and Central Asian Countries
Scientific Annals of Economics and Business, 2016 The main purpose of this paper is to determine and analyse the factors that affected economic growth in the EU’s Eastern Partnership and Central Asian countries in the 2000-2015 period. Economic growth is one of the main targets of economic policy of any
Sharipov Ilkhom
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Equilibrium dynamics in two-sector models of endogenous growth [PDF]
, 1994 This paper presents an account of the dynamics of endogenous growth models with physical capital and human capital. We consider some important extensions of the basic framework of Lucas (1988) and Uzawa (1964), including physical capital in the human ...
Ortigueira, Salvador +2 more
core +1 more source
Causality between Economic Growth and Consumption of Natural Gas in I. R. Iran [PDF]
Pizhūhishnāmah-i Iqtiṣād-i Inirzhī-i Īrān, 2012 This study investigates interactions between economic growth and natural gas consumption, using times series data. The paper uses vector error correction technique and Johansen Co-integration test for the period 1353-1386.
Teymoor Mohammadi +2 more
doaj
An endogenous growth model with endogenous money supply. Integration of post-Keynesian growth model
PSL Quarterly Review, 2013 The work attempts to integrate the growth models by authors such as Kalecki, Harrod, Robinson and Kaldor, together with an introduction on monetary aspects, based on the endogenous money supply theory.
K. WATANABE
doaj +1 more source