Results 1 to 10 of about 5,353,534 (199)

A universal UHPLC-CAD platform for the quantification of polysaccharide antigens

Scientific Reports, 2023
Several glycoconjugate-based vaccines against bacterial infections have been developed and licensed for human use. Polysaccharide (PS) analysis and characterization is therefore critical to profile the composition of polysaccharide-based vaccines. For PS
A. Corrado, M. De Martino, V. Bordoni, S. Giannini, F. Rech, S. Cianetti, F. Berti, C. Magagnoli, R. De Ricco   +8 more
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Identifying the Geographical Origin of Tobacco Leaf by Strontium and Lead Isotopic with Mineral Elemental Fingerprint

International Journal of Chemical Engineering, 2022
The primary aim of this paper was to identifying the geographical origin of tobacco leaves based on stable isotopic and mineral elemental fingerprint. We collected eighty-one tobacco leaf samples from Argentina, Brazil, Zimbabwe, the U.S., Zambia, and ...
Liu Hong, Wenyuan Wang, Yang Su, Guiping Zhang, Yong Su, Chenming Zhang, Jianhua Chen, Wei Zhe, Zhihua Liu, Jianyong Cui, Deshou Mao, Jin Wang   +11 more
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Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy

Communications Biology, 2021
Claire Patterson et al. present the design and development of AZD0466, a drug-dendrimer conjugate, and use preclinical and mathematical models to determine the optimal release rate of the drug from the dendrimer carrier for maximal therapeutic index in ...
Claire M. Patterson, Srividya B. Balachander, Iain Grant, Petar Pop-Damkov, Brian Kelly, William McCoull, Jeremy Parker, Michael Giannis, Kathryn J. Hill, Francis D. Gibbons, Edward J. Hennessy, Paul Kemmitt, Alexander R. Harmer, Sonya Gales, Stuart Purbrick, Sean Redmond, Matthew Skinner, Lorraine Graham, J. Paul Secrist, Alwin G. Schuller, Shenghua Wen, Ammar Adam, Corinne Reimer, Justin Cidado, Martin Wild, Eric Gangl, Stephen E. Fawell, Jamal Saeh, Barry R. Davies, David J. Owen, Marianne B. Ashford   +30 more
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The effect of 8 plant extracts and combinations on post-prandial blood glucose and insulin responses in healthy adults: a randomized controlled trial

Nutrition & Metabolism, 2020
Background Lower post-prandial glucose (PPG) and insulin (PPI) responses to foods are associated with reduced diabetes risk and progression. Several plant extracts have been proposed to reduce PPG or PPI by inhibiting enzymes or transporters involved in ...
David J. Mela, Xiu-Zhen Cao, Rajendra Dobriyal, Mark I. Fowler, Li Lin, Manoj Joshi, Theo J. P. Mulder, Peter G. Murray, Harry P. F. Peters, Mario A. Vermeer, Zhang Zhang   +10 more
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Vitamin D status of the Russian adult population from 2013 to 2018

Scientific Reports, 2022
Vitamin D deficiency is widespread globally, however available data for the Russian adult population is fragmented. This cross-sectional study used secondary data for individuals undergoing testing for vitamin D concentrations from 2013 to 2018 by ...
Daria V. Smirnova, Colin D. Rehm, Ronald D. Fritz, Inga S. Kutepova, Maria S. Soshina, Yulia A. Berezhnaya   +5 more
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Cysteine metabolic engineering and selective disulfide reduction produce superior antibody-drug-conjugates

Scientific Reports, 2022
Next-generation site-specific cysteine-based antibody–drug-conjugates (ADCs) broaden therapeutic index by precise drug-antibody attachments. However, manufacturing such ADCs for clinical validation requires complex full reduction and reoxidation ...
Renée Procopio-Melino, Frank W. Kotch, Amar S. Prashad, Jose M. Gomes, Wenge Wang, Bo Arve, Andrew Dawdy, Lawrence Chen, Justin Sperry, Christine Hosselet, Tao He, Ronald Kriz, Laura Lin, Kimberly Marquette, Lioudmila Tchistiakova, Will Somers, Jason C. Rouse, Xiaotian Zhong   +17 more
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Improving the efficiency and effectiveness of an industrial SARS-CoV-2 diagnostic facility

Scientific Reports, 2022
On 11th March 2020, the UK government announced plans for the scaling of COVID-19 testing, and on 27th March 2020 it was announced that a new alliance of private sector and academic collaborative laboratories were being created to generate the testing ...
Julie A. Douthwaite, Christopher A. Brown, John R. Ferdinand, Rahul Sharma, Jane Elliott, Molly A. Taylor, Nancy T. Malintan, Hannah Duvoisin, Thomas Hill, Oona Delpuech, Alexandra L. Orton, Haidee Pitt, Fred Kuenzi, Simon Fish, David J. Nicholls, Anna Cuthbert, Ian Richards, Giles Ratcliffe, Abhishek Upadhyay, Abigail Marklew, Craig Hewitt, Douglas Ross-Thriepland, Christopher Brankin, Matthieu Chodorge, Gareth Browne, Palwinder K. Mander, Ruud M. DeWildt, Shane Weaver, Penny A. Smee, Joost van Kempen, Jon G. Bartlett, Paula M. Allen, Emma L. Koppe, Charlotte A. Ashby, Julian D. Phipps, Nalini Mehta, David J. Brierley, David G. Tew, Melanie V. Leveridge, Stuart M. Baddeley, Ian G. Goodfellow, Clive Green, Chris Abell, Andy Neely, Ian Waddell, Steve Rees, Patrick H. Maxwell, Menelas N. Pangalos, Rob Howes, Roger Clark   +49 more
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SAR228810: an antibody for protofibrillar amyloid β peptide designed to reduce the risk of amyloid-related imaging abnormalities (ARIA)

Alzheimer’s Research & Therapy, 2018
Background Anti-amyloid β (Aβ) immunotherapy represents a major area of drug development for Alzheimer’s disease (AD). However, Aβ peptide adopts multiple conformations and the pathological forms to be specifically targeted have not been identified.
Laurent Pradier, Véronique Blanchard-Brégeon, Andrees Bohme, Thomas Debeir, Jean Menager, Patrick Benoit, Pascal Barneoud, Véronique Taupin, Philippe Bertrand, Philippe Dugay, Béatrice Cameron, Yi Shi, Souad Naimi, Marc Duchesne, Marie Gagnaire, Tim Weeden, Tara Travaline, David Reczek, Leonard Khiroug, Mohamed Slaoui, Pascale Brunel, Hidehiro Fukuyama, Jeffrey Ravetch, Thierry Canton, Caroline Cohen   +24 more
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Tumour-on-chip microfluidic platform for assessment of drug pharmacokinetics and treatment response

Communications Biology, 2021
Petreus et al. describe a platform combining 3D tumour-on-chip technology and pump driven microfluidics to study drug effects at physiological exposures preclinically.
Tudor Petreus, Elaine Cadogan, Gareth Hughes, Aaron Smith, Venkatesh Pilla Reddy, Alan Lau, Mark James O’Connor, Susan Critchlow, Marianne Ashford, Lenka Oplustil O’Connor   +9 more
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A preclinical model of peripheral T‐cell lymphoma GATA3 reveals DNA damage response pathway vulnerability

EMBO Molecular Medicine, 2022
Peripheral T‐cell lymphoma (PTCL) represents a rare group of heterogeneous diseases in urgent need of effective treatments. A scarcity of disease‐relevant preclinical models hinders research advances.
Elizabeth A Kuczynski, Giulia Morlino, Alison Peter, Anna M L Coenen‐Stass, Jennifer I Moss, Neha Wali, Oona Delpuech, Avinash Reddy, Anisha Solanki, Charles Sinclair, Dinis P Calado, Larissa S Carnevalli   +11 more
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