Results 1 to 10 of about 8,764,171 (325)

Overview of R(D) and R(D*)

open access: yes, 2022
In this talk, an overview of the latest R(D(∗) measurements performed at the Belle and LHCbexperiments is presented. The main approach and methodology of each measurement is discussed,along with the current limitations and potential improvements. Furthermore, the prospects forR(D(∗)) measurements at Belle II and the tools developed to improve their ...
Cheaib, Racha, Belle II Collaboration
openaire   +5 more sources

A universal UHPLC-CAD platform for the quantification of polysaccharide antigens

open access: yesScientific Reports, 2023
Several glycoconjugate-based vaccines against bacterial infections have been developed and licensed for human use. Polysaccharide (PS) analysis and characterization is therefore critical to profile the composition of polysaccharide-based vaccines. For PS
A. Corrado   +8 more
doaj   +1 more source

Identifying the Geographical Origin of Tobacco Leaf by Strontium and Lead Isotopic with Mineral Elemental Fingerprint

open access: yesInternational Journal of Chemical Engineering, 2022
The primary aim of this paper was to identifying the geographical origin of tobacco leaves based on stable isotopic and mineral elemental fingerprint. We collected eighty-one tobacco leaf samples from Argentina, Brazil, Zimbabwe, the U.S., Zambia, and ...
Liu Hong   +11 more
doaj   +1 more source

Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy

open access: yesCommunications Biology, 2021
Claire Patterson et al. present the design and development of AZD0466, a drug-dendrimer conjugate, and use preclinical and mathematical models to determine the optimal release rate of the drug from the dendrimer carrier for maximal therapeutic index in ...
Claire M. Patterson   +30 more
doaj   +1 more source

The effect of 8 plant extracts and combinations on post-prandial blood glucose and insulin responses in healthy adults: a randomized controlled trial

open access: yesNutrition & Metabolism, 2020
Background Lower post-prandial glucose (PPG) and insulin (PPI) responses to foods are associated with reduced diabetes risk and progression. Several plant extracts have been proposed to reduce PPG or PPI by inhibiting enzymes or transporters involved in ...
David J. Mela   +10 more
doaj   +1 more source

Vitamin D status of the Russian adult population from 2013 to 2018

open access: yesScientific Reports, 2022
Vitamin D deficiency is widespread globally, however available data for the Russian adult population is fragmented. This cross-sectional study used secondary data for individuals undergoing testing for vitamin D concentrations from 2013 to 2018 by ...
Daria V. Smirnova   +5 more
doaj   +1 more source

$R(D)$ and $R(D^*)$ at Belle [PDF]

open access: yesProceedings of 18th International Conference on B-Physics at Frontier Machines — PoS(Beauty2019), 2020
A new measurement of the ratio of the branching fractions $R(D^{(*)}) = \mathcal{B}(\overline{B}\to D^{(*)}\tau^-\overline{\nu}_\tau) / \mathcal{B}(\overline{B}\to D^{(*)}\ell^-\overline{\nu}_\ell)$, $\ell = e, \mu$ is performed using a semileptonic tagging method with the data sample of $772 \times 10^6$ $B\overline{B}$ pairs collected at the Belle
openaire   +1 more source

Cysteine metabolic engineering and selective disulfide reduction produce superior antibody-drug-conjugates

open access: yesScientific Reports, 2022
Next-generation site-specific cysteine-based antibody–drug-conjugates (ADCs) broaden therapeutic index by precise drug-antibody attachments. However, manufacturing such ADCs for clinical validation requires complex full reduction and reoxidation ...
Renée Procopio-Melino   +17 more
doaj   +1 more source

Improving the efficiency and effectiveness of an industrial SARS-CoV-2 diagnostic facility

open access: yesScientific Reports, 2022
On 11th March 2020, the UK government announced plans for the scaling of COVID-19 testing, and on 27th March 2020 it was announced that a new alliance of private sector and academic collaborative laboratories were being created to generate the testing ...
Julie A. Douthwaite   +49 more
doaj   +1 more source

Tumour-on-chip microfluidic platform for assessment of drug pharmacokinetics and treatment response

open access: yesCommunications Biology, 2021
Petreus et al. describe a platform combining 3D tumour-on-chip technology and pump driven microfluidics to study drug effects at physiological exposures preclinically.
Tudor Petreus   +9 more
doaj   +1 more source

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