Results 11 to 20 of about 5,369,590 (244)

SAR228810: an antibody for protofibrillar amyloid β peptide designed to reduce the risk of amyloid-related imaging abnormalities (ARIA)

Alzheimer’s Research & Therapy, 2018
Background Anti-amyloid β (Aβ) immunotherapy represents a major area of drug development for Alzheimer’s disease (AD). However, Aβ peptide adopts multiple conformations and the pathological forms to be specifically targeted have not been identified.
Laurent Pradier, Véronique Blanchard-Brégeon, Andrees Bohme, Thomas Debeir, Jean Menager, Patrick Benoit, Pascal Barneoud, Véronique Taupin, Philippe Bertrand, Philippe Dugay, Béatrice Cameron, Yi Shi, Souad Naimi, Marc Duchesne, Marie Gagnaire, Tim Weeden, Tara Travaline, David Reczek, Leonard Khiroug, Mohamed Slaoui, Pascale Brunel, Hidehiro Fukuyama, Jeffrey Ravetch, Thierry Canton, Caroline Cohen   +24 more
doaj   +1 more source

Tumour-on-chip microfluidic platform for assessment of drug pharmacokinetics and treatment response

Communications Biology, 2021
Petreus et al. describe a platform combining 3D tumour-on-chip technology and pump driven microfluidics to study drug effects at physiological exposures preclinically.
Tudor Petreus, Elaine Cadogan, Gareth Hughes, Aaron Smith, Venkatesh Pilla Reddy, Alan Lau, Mark James O’Connor, Susan Critchlow, Marianne Ashford, Lenka Oplustil O’Connor   +9 more
doaj   +1 more source

A preclinical model of peripheral T‐cell lymphoma GATA3 reveals DNA damage response pathway vulnerability

EMBO Molecular Medicine, 2022
Peripheral T‐cell lymphoma (PTCL) represents a rare group of heterogeneous diseases in urgent need of effective treatments. A scarcity of disease‐relevant preclinical models hinders research advances.
Elizabeth A Kuczynski, Giulia Morlino, Alison Peter, Anna M L Coenen‐Stass, Jennifer I Moss, Neha Wali, Oona Delpuech, Avinash Reddy, Anisha Solanki, Charles Sinclair, Dinis P Calado, Larissa S Carnevalli   +11 more
doaj   +1 more source

Targeting DNA damage response components induces enhanced STING-dependent type-I IFN response in ATM deficient cancer cells and drives dendritic cell activation

OncoImmunology, 2022
The concept of exploiting tumor intrinsic deficiencies in DNA damage repair mechanisms by inhibiting compensatory DNA repair pathways is well established. For example, ATM-deficient cells show increased sensitivity to the ATR inhibitor ceralasertib.
Marta Lopez-Pelaez, Lucy Young, Mercedes Vazquez-Chantada, Nadine Nelson, Steve Durant, Robert W. Wilkinson, Edmund Poon, Miguel Gaspar, Viia Valge-Archer, Paul Smith, Simon J. Dovedi   +10 more
doaj   +1 more source

Germline-encoded neutralization of a Staphylococcus aureus virulence factor by the human antibody repertoire

Nature Communications, 2016
Staphylococcus aureuscan both cause disease in humans and be present with no discernible effect. Here, the authors look in detail at the memory immune response against a protein involved in iron acquisition.
Yik Andy Yeung, Davide Foletti, Xiaodi Deng, Yasmina Abdiche, Pavel Strop, Jacob Glanville, Steven Pitts, Kevin Lindquist, Purnima D. Sundar, Marina Sirota, Adela Hasa-Moreno, Amber Pham, Jody Melton Witt, Irene Ni, Jaume Pons, David Shelton, Arvind Rajpal, Javier Chaparro-Riggers   +17 more
doaj   +1 more source

Measurement of R(D) and R(D∗) with a Semileptonic Tagging Method

, 2020
The experimental results on the ratios of branching fractions R(D) = B((B) over bar -> D tau(-)(nu) over bar (tau))/B((B) over bar -> Dl(-)(nu) over bar (e)) and R(D*) = B((B) over bar -> D*tau(-)(nu) over bar (tau))/B((B) over bar -> D*tau(-)(nu) over bar (e)), where l denotes an electron or a muon, show a long-standing discrepancy with the standard ...
Belle Collaboration, Schnell, Gunar
  +7 more sources

TNER: a novel background error suppression method for mutation detection in circulating tumor DNA

BMC Bioinformatics, 2018
Background Ultra-deep next-generation sequencing of circulating tumor DNA (ctDNA) holds great promise as a tool for the early detection of cancer and for monitoring disease progression and therapeutic responses. However, the low abundance of ctDNA in the
Shibing Deng, Maruja Lira, Donghui Huang, Kai Wang, Crystal Valdez, Jennifer Kinong, Paul A. Rejto, Jadwiga Bienkowska, James Hardwick, Tao Xie   +9 more
doaj   +1 more source

On Nikol’skii Inequalities for Domains in $${\mathbb {R}}^d$$ R d [PDF]

Constructive Approximation, 2016
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Ditzian, Z., Prymak, A.
openaire   +2 more sources

Complementary NAD+ replacement strategies fail to functionally protect dystrophin-deficient muscle

Skeletal Muscle, 2020
Background Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder stemming from a loss of functional dystrophin. Current therapeutic options for DMD are limited, as small molecule modalities remain largely unable to decrease the ...
David W. Frederick, Alan V. McDougal, Melisa Semenas, Johanna Vappiani, Andrea Nuzzo, John C. Ulrich, J. David Becherer, Frank Preugschat, Eugene L. Stewart, Daniel C. Sévin, H. Fritz Kramer   +10 more
doaj   +1 more source

Clinical impact of subclonal EGFR T790M mutations in advanced-stage EGFR-mutant non-small-cell lung cancers

Nature Communications, 2021
A recent clinical trial shows that a proportion of lung cancer patients carrying the EGFR T790M mutation develop resistance to osimertinib. In this study, the authors show that T790M subclonality is associated with worse clinical outcome likely through ...
Tereza Vaclova, Ursula Grazini, Lewis Ward, Daniel O’Neill, Aleksandra Markovets, Xiangning Huang, Juliann Chmielecki, Ryan Hartmaier, Kenneth S. Thress, Paul D. Smith, J. Carl Barrett, Julian Downward, Elza C. de Bruin   +12 more
doaj   +1 more source