Results 11 to 20 of about 5,629,590 (199)
EMBO Molecular Medicine, 2022 Peripheral T‐cell lymphoma (PTCL) represents a rare group of heterogeneous diseases in urgent need of effective treatments. A scarcity of disease‐relevant preclinical models hinders research advances.
Elizabeth A Kuczynski +11 more
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OncoImmunology, 2022 The concept of exploiting tumor intrinsic deficiencies in DNA damage repair mechanisms by inhibiting compensatory DNA repair pathways is well established. For example, ATM-deficient cells show increased sensitivity to the ATR inhibitor ceralasertib.
Marta Lopez-Pelaez +10 more
doaj +1 more source
Nature Communications, 2016 Staphylococcus aureuscan both cause disease in humans and be present with no discernible effect. Here, the authors look in detail at the memory immune response against a protein involved in iron acquisition.
Yik Andy Yeung +17 more
doaj +1 more source
TNER: a novel background error suppression method for mutation detection in circulating tumor DNA
BMC Bioinformatics, 2018 Background Ultra-deep next-generation sequencing of circulating tumor DNA (ctDNA) holds great promise as a tool for the early detection of cancer and for monitoring disease progression and therapeutic responses. However, the low abundance of ctDNA in the
Shibing Deng +9 more
doaj +1 more source
Nature Communications, 2021 A recent clinical trial shows that a proportion of lung cancer patients carrying the EGFR T790M mutation develop resistance to osimertinib. In this study, the authors show that T790M subclonality is associated with worse clinical outcome likely through ...
Tereza Vaclova +12 more
doaj +1 more source
Complementary NAD+ replacement strategies fail to functionally protect dystrophin-deficient muscle
Skeletal Muscle, 2020 Background Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder stemming from a loss of functional dystrophin. Current therapeutic options for DMD are limited, as small molecule modalities remain largely unable to decrease the ...
David W. Frederick +10 more
doaj +1 more source
BMC Microbiology, 2021 Background With increasing concerns about the impact of frequent antibiotic usage on the human microbiome, it is important to characterize the potential for such effects in early antibiotic drug development clinical trials.
Andrea Nuzzo +7 more
doaj +1 more source
Metabolism-driven in vitro/in vivo disconnect of an oral ERɑ VHL-PROTAC
Communications BiologyTargeting the estrogen receptor alpha (ERα) pathway is validated in the clinic as an effective means to treat ER+ breast cancers. Here we present the development of a VHL-targeting and orally bioavailable proteolysis-targeting chimera (PROTAC) degrader ...
Thomas G. Hayhow +35 more
doaj +1 more source
A simeprevir-inducible molecular switch for the control of cell and gene therapies
Nature Communications, 2023 Chemical inducer of dimerization (CID) modules can be used effectively as molecular switches to control biological processes, and thus there is significant interest within the synthetic biology community in identifying novel CID systems.
Stacey E. Chin +12 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
wiley +1 more source