Results 31 to 40 of about 8,764,171 (325)
Metabolism-driven in vitro/in vivo disconnect of an oral ERɑ VHL-PROTAC
Communications BiologyTargeting the estrogen receptor alpha (ERα) pathway is validated in the clinic as an effective means to treat ER+ breast cancers. Here we present the development of a VHL-targeting and orally bioavailable proteolysis-targeting chimera (PROTAC) degrader ...
Thomas G. Hayhow +35 more
doaj +1 more source
BMC Microbiology, 2021 An amendment to this paper has been published and can be accessed via the original article.
Andrea Nuzzo +7 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
wiley +1 more source
A novel automated SARS-CoV-2 saliva PCR test protects a global asymptomatic workforce
Scientific Reports, 2021 Regular PCR testing of nasopharyngeal swabs from symptomatic individuals for SARS-CoV-2 virus has become the established method by which health services are managing the COVID-19 pandemic.
Nikki Carter +17 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background An international Delphi panel of experts developed consensus statements to delineate the circumstances where the risks of dexamethasone as an antiemetic do and do not outweigh its benefits. Procedure Experts in supportive care of pediatric patients were invited to participate.
Negar Shavandi +20 more
wiley +1 more source
Research Joint Ventures, Optimal Licensing, and R&D Subsidy Policy [PDF]
, 2006 We reconsider the justifications of R&D subsidies by Spencer and Brander (1983) and others by allowing firms to pool R&D investments and license innovations.
Fan, Cuihong, Wolfstetter, Elmar G.
core +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Blinatumomab has been shown to be highly effective for patients with pediatric B‐ALL and has recently become standard of care therapy. Due to its past use in the clinical trial setting, there is limited information available about real‐world administration.
Katelyn Oranges +12 more
wiley +1 more source
Inapproximability for Metric Embeddings into R^d [PDF]
2008 49th Annual IEEE Symposium on Foundations of Computer Science, 2008 We consider the problem of computing the smallest possible distortion for embedding of a given n-point metric space into R^d, where d is fixed (and small). For d=1, it was known that approximating the minimum distortion with a factor better than roughly n^(1/12) is NP-hard. From this result we derive inapproximability with factor roughly n^(1/(22d-10))
Jirí Matousek 0001 +1 more
openaire +2 more sources
An Investigation of Firm-Level R&D Capabilities in East Asia [PDF]
, 2002 This paper uses a survey of 1,826 firms distributed over ten East Asian metropolitan areas – Jakarta, Kuala Lumpur, Manila, Seoul, and five Chinese cities – to investigate the sources of firm-level R&D capabilities.
Jefferson, Gary H., Kaifeng, Zhong
core
Diagnostic PathologyBackground Breast cancer was previously categorized as human epidermal growth factor receptor 2 (HER2)-positive (immunohistochemistry [IHC] 3+, IHC 2+ / in situ hybridization [ISH]–positive) or HER2-negative (IHC 0, IHC 1+, IHC 2+/ISH−).
Agata Wróbel +7 more
doaj +1 more source