Endogenous opioid systems alterations in pain and opioid use disorder. [PDF]
Front Syst Neurosci, 2022 Decades of research advances have established a central role for endogenous opioid systems in regulating reward processing, mood, motivation, learning and memory, gastrointestinal function, and pain relief.
Higginbotham JA +3 more
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Challenges and new opportunities for detecting endogenous opioid peptides in reward. [PDF]
Addict Neurosci, 2022 The endogenous opioid peptide system, comprised of enkephalins, endorphins, dynorphins, and nociceptin, is a highly complex neurobiological system. Opioid peptides are derived from four precursor molecules and undergo several processing events yielding ...
Conway SM, Mikati MO, Al-Hasani R.
europepmc +2 more sources
Multiple Sclerosis and the Endogenous Opioid System. [PDF]
Front Neurosci, 2021 Multiple sclerosis (MS) is an autoimmune disease characterized by chronic inflammation, neuronal degeneration and demyelinating lesions within the central nervous system.
Dworsky-Fried Z +3 more
europepmc +2 more sources
Risk for opioid misuse in chronic pain patients is associated with endogenous opioid system dysregulation. [PDF]
Transl Psychiatry, 2022 µ-Opioid receptors (MOR) are a major target of endogenous and exogenous opioids, including opioid pain medications. The µ-opioid neurotransmitter system is heavily implicated in the pathophysiology of chronic pain and opioid use disorder and, as such ...
Ballester J +5 more
europepmc +2 more sources
Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia. [PDF]
Pain Rep, 2021 . Introduction:. Negative affect, including anxiety and depression, is prevalent in chronic pain states such as osteoarthritis (OA) and associated with greater use of opioid analgesics, potentially contributing to present and future opioid crises ...
Lillywhite A +10 more
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A Comprehensive Analysis of Fibromyalgia and the Role of the Endogenous Opioid System. [PDF]
BiomedicinesFibromyalgia represents a chronic pain disorder characterized by musculoskeletal pain, fatigue, and cognitive impairments. The exact mechanisms underlying fibromyalgia remain undefined; as a result, diagnosis and treatment present considerable challenges.
García-Domínguez M.
europepmc +2 more sources
Exploiting the angiotensin-converting enzyme pathway to augment endogenous opioid signaling. [PDF]
Commun BiolAngiotensin Converting Enzyme (ACE) impacts hemodynamics by regulating the conversion of angiotensin I to the vasoconstricting angiotensin II. We recently identified a non-canonical central role of ACE in the degradation of enkephalin heptapeptide, Met ...
Dobariya P +4 more
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The endogenous opioid system in the medial prefrontal cortex mediates ketamine's antidepressant-like actions. [PDF]
Transl PsychiatryRecent studies have implicated the endogenous opioid system in the antidepressant actions of ketamine, but the underlying mechanisms remain unclear.
Jiang C +3 more
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Estradiol and Mu opioid-mediated reward: The role of estrogen receptors in opioid use
Addiction Neuroscience, 2023 Opioid use and opioid use disorder are characterized by sex and gender differences, and some of these differences may be mediated by differences in the hormonal milieu within and across individuals.
Sarah B. Ethridge, Mark A. Smith
doaj +1 more source
Chronic morphine treatment attenuates cell growth of human BT474 breast cancer cells by rearrangement of the ErbB signalling network. [PDF]
, 2013 There is increasing evidence that opioid analgesics may interfere with tumour growth. It is currently thought that these effects are mediated by transactivation of receptor tyrosine kinase (RTK)-controlled ERK1/2 and Akt signalling.
Ammer, Hermann +2 more
core +8 more sources