Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia [PDF]
PAIN Reports, 2021 . Introduction:. Negative affect, including anxiety and depression, is prevalent in chronic pain states such as osteoarthritis (OA) and associated with greater use of opioid analgesics, potentially contributing to present and future opioid crises ...
Amanda Lillywhite +10 more
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Endogenous opioid systems alterations in pain and opioid use disorder [PDF]
Frontiers in Systems Neuroscience, 2022 Decades of research advances have established a central role for endogenous opioid systems in regulating reward processing, mood, motivation, learning and memory, gastrointestinal function, and pain relief.
Jessica A. Higginbotham +11 more
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Challenges and new opportunities for detecting endogenous opioid peptides in reward [PDF]
Addiction Neuroscience, 2022 The endogenous opioid peptide system, comprised of enkephalins, endorphins, dynorphins, and nociceptin, is a highly complex neurobiological system. Opioid peptides are derived from four precursor molecules and undergo several processing events yielding ...
Sineadh M. Conway +2 more
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Multiple Sclerosis and the Endogenous Opioid System [PDF]
Frontiers in Neuroscience, 2021 Multiple sclerosis (MS) is an autoimmune disease characterized by chronic inflammation, neuronal degeneration and demyelinating lesions within the central nervous system.
Zoë Dworsky-Fried +7 more
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Risk for opioid misuse in chronic pain patients is associated with endogenous opioid system dysregulation [PDF]
Translational Psychiatry, 2022 µ-Opioid receptors (MOR) are a major target of endogenous and exogenous opioids, including opioid pain medications. The µ-opioid neurotransmitter system is heavily implicated in the pathophysiology of chronic pain and opioid use disorder and, as such ...
Javier Ballester +5 more
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Exploiting the angiotensin-converting enzyme pathway to augment endogenous opioid signaling [PDF]
Communications BiologyAngiotensin Converting Enzyme (ACE) impacts hemodynamics by regulating the conversion of angiotensin I to the vasoconstricting angiotensin II. We recently identified a non-canonical central role of ACE in the degradation of enkephalin heptapeptide, Met ...
Prakashkumar Dobariya +4 more
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A Comprehensive Analysis of Fibromyalgia and the Role of the Endogenous Opioid System [PDF]
BiomedicinesFibromyalgia represents a chronic pain disorder characterized by musculoskeletal pain, fatigue, and cognitive impairments. The exact mechanisms underlying fibromyalgia remain undefined; as a result, diagnosis and treatment present considerable challenges.
Mario García-Domínguez
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The endogenous opioid system in the medial prefrontal cortex mediates ketamine’s antidepressant-like actions [PDF]
Translational PsychiatryRecent studies have implicated the endogenous opioid system in the antidepressant actions of ketamine, but the underlying mechanisms remain unclear.
Cheng Jiang +3 more
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Regulation of Opioid Receptors by Their Endogenous Opioid Peptides. [PDF]
Cell Mol Neurobiol, 2021 Gupta A +8 more
europepmc +3 more sources
Endogenous Opioid Signaling in the Mouse Retina Modulates Pupillary Light Reflex. [PDF]
Int J Mol Sci, 2021 Cleymaet AM, Berezin CT, Vigh J.
europepmc +3 more sources