Results 131 to 140 of about 783,260 (291)

Opiate Drug Seeking and Addiction: The Influence of Sucrose Consumption on the Acquisition and Expression of Morphine-induced Conditioned Place Preferences (CPP) [PDF]

open access: yes, 2019
Sucrose intake may lead to changes in brain and behavior similar to the effects of abused drugs. For example, sucrose may agonize endogenous opiate systems and modulate opiate-seeking behavior.
Bakner, Lee   +3 more
core   +1 more source

Opioidergic signaling contributes to food-mediated suppression of AgRP neurons

open access: yesCell Reports
Summary: Opioids are generally known to promote hedonic food consumption. Although much of the existing evidence is primarily based on studies of the mesolimbic pathway, endogenous opioids and their receptors are widely expressed in hypothalamic appetite
Nilufer Sayar-Atasoy   +11 more
doaj   +1 more source

Adrenal Insufficiency During Treatment With Immune‐Checkpoint Inhibitors: How to Simplify the Diagnostic Pathway?

open access: yesClinical Endocrinology, EarlyView.
ABSTRACT Objective and Background Early identification of adrenal insufficiency (AI) during immune‐checkpoint inhibitors (ICIs) is crucial to prevent life‐threatening consequences; however, the diagnosis is challenging. Design, Patients and Measurement In this prospective observational study, ICI‐treated cancer patients with morning serum cortisol (SC)
Alice Nervo   +6 more
wiley   +1 more source

A closer look at Doleac and Mukherjee (2022) and the effects of naloxone access laws on opioid ER admissions

open access: yesEconomic Inquiry, EarlyView.
Abstract In their 2022 study, ‘The Effects of Naloxone Access Laws on Opioid Abuse, Mortality, and Crime,’ Doleac and Mukherjee conclude that broadening access to a life‐saving drug—naloxone—does not reduce opioid‐related mortality as the drug simultaneously encourages riskier drug use. I show issues with their data, design, and estimation methods. For
Sergey Alexeev
wiley   +1 more source

Activation of endogenous opioid gene expression in human keratinocytes and fibroblasts by pulsed radiofrequency energy fields

open access: yesJournal of Pain Research, 2012
John Moffett,1 Linley M Fray,1 Nicole J Kubat21Life Science Department, 2Independent Consultant, Regenesis Biomedical Inc, Scottsdale, AZ, USABackground: Pulsed radiofrequency energy (PRFE) fields are being used increasingly for the treatment of pain ...
Moffett J, Fray LM, Kubat NJ
doaj  

Advances in Achieving Opioid Analgesia Without Side Effects

open access: yesFrontiers in Pharmacology, 2018
Opioids are the most effective drugs for the treatment of severe pain, but they also cause addiction and overdose deaths, which have led to a worldwide opioid crisis. Therefore, the development of safer opioids is urgently needed.
Halina Machelska, Melih Ö. Celik
doaj   +1 more source

Involvement of the endogenous opioid system in the psychopharmacological actions of ethanol: the role of acetaldehyde

open access: yesFrontiers in Behavioral Neuroscience, 2013
Significant evidence implicates the endogenous opioid system (EOS) (opioid peptides and receptors) in the mechanisms underlying the psychopharmacological effects of ethanol.
L. Font, M. Luján, R. Pastor
semanticscholar   +1 more source

Waning light, waxing pain: The lunar cycle's association with migraine headache occurrence

open access: yesHeadache: The Journal of Head and Face Pain, EarlyView.
Plain Language Summary While migraine headaches can be hard to predict, some patients believe headaches are connected to the moon‘s phases. Our research showed that migraine attacks were 34% more likely to occur during the new moon than during the full moon.
Alexander Yoo   +5 more
wiley   +1 more source

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