Results 161 to 170 of about 74,218 (327)

GABAB receptor‐mediated modulation of sensory neuron excitability: Roles of CaV2.2, G‐protein‐coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation‐activated cyclic nucleotide‐gated (HCN) channels in human and mouse nociception

Experimental Physiology, EarlyView.
Abstract Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage‐gated calcium and potassium channels by G protein‐coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the analgesic peptide α‐conotoxin Vc1.1 activate GABAB receptors (GABABR), resulting in inhibition of CaV2.2 and ...
Mariana Brizuela, Anuja R. Bony, Sonia Garcia‐Caraballo, David J. Adams, Stuart M. Brierley   +4 more
wiley   +1 more source

Deletion of arrestin-3 does not reduce drug-seeking behavior in a longitudinal paradigm of oral morphine self-administration

Frontiers in Pharmacology
IntroductionOpioid drugs are potent analgesics that mimic the endogenous opioid peptides, endorphins and enkephalins, by activating the µ-opioid receptor.
Sarah Warren Gooding, Lindsey Felth, Randi Foxall, Zachary Rosa, Kyle Ireton, Izabella Sall, Joshua Gipoor, Anirudh Gaur, Madeline King, Noah Dirks, Cheryl Allyne Whistler, Jennifer Lynne Whistler, Jennifer Lynne Whistler   +12 more
doaj   +1 more source

Transcranial photobiomodulation with near‐infrared laser induces analgesia in rats

The Journal of Physiology, EarlyView.
Abstract figure legend Transcranial photobiomodulation (tPBM) with a 1064 nm laser alleviated pain. Local field potential (LFP) intensity markedly increased following formalin injection, indicating nociceptive activation. However, after tPBM, this formalin‐induced LFP hyperactivation was diminished. Meanwhile, tPBM preserved brain connectivity that was
Zhen Wang, Anqi Wu, Hanli Liu, Yuan Bo Peng   +3 more
wiley   +1 more source

Endogenous Opioid Imbalance as a Potential Factor Involved in the Pathogenesis of Chronic Kidney Disease-Associated Pruritus in Dialysis Patients. [PDF]

J Clin Med, 2023
Wala-Zielińska K, Świerczyńska-Mróz K, Krajewski PK, Nowicka-Suszko D, Krajewska M, Szepietowski JC.   +5 more
europepmc   +1 more source

Millimeter wave‐induced suppression of B16 F10 melanoma growth in mice: Involvement of endogenous opioids

, 2004
Alexander A. Radzievsky, Oleg Gordiienko, Imre Szabó, S.I. Alekseev, Marvin C. Ziskin   +4 more
openalex   +2 more sources

Potential health benefits of cold‐water immersion: the central role of PGC‐1α

The Journal of Physiology, EarlyView.
Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer, Wafa Douzi, Johannes Burtscher   +2 more
wiley   +1 more source

Endogenous opioid signaling in the retina modulates sleep/wake activity in mice. [PDF]

Neurobiol Sleep Circadian Rhythms, 2022
Berezin CT, Bergum N, Luchini KA, Curdts S, Korkis C, Vigh J.   +5 more
europepmc   +1 more source

Hypofractionated Radiation Therapy for Pain Relief of Patients With Spinal Metastasis: A Real‐World Analysis

Cancer Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Purpose Spinal metastases may cause pain, neurological compromise, paraplegia, and limb movement disorders; their management requires a comprehensive approach. Alongside systemic anti‐tumor therapies, focal interventions such as radiotherapy, bone‐modifying agents, and surgery are crucial for slowing disease progression and managing pain in ...
Lu Sun, Fan Luo, Yajuan Zhou, Xiyou Liu, Pingping Zhang, Dan Li, Yi Peng   +6 more
wiley   +1 more source

The Involvement of the Endogenous Opioid System in the Gastrointestinal Aging in Mice and Humans. [PDF]

Int J Mol Sci, 2022
Szymaszkiewicz A, Talar M, Włodarczyk J, Świerczyński M, Bartoszek A, Krajewska J, Mokrowiecka A, Małecka-Wojciesko E, Fichna J, Zielińska M.   +9 more
europepmc   +1 more source

Cryo-EM structure of human κ-opioid receptor-Gi complex bound to an endogenous agonist dynorphin A

, 2022
Yuxiang Chen, Bo Chen, Tingting Wu, Fangfang Zhou, Fei Xu   +4 more
openalex   +1 more source