Results 181 to 190 of about 74,218 (327)

Naldemedine for the Prevention of Recurrent Acute Pancreatitis: A Randomised, Double‐Blind, Placebo‐Controlled Trial

United European Gastroenterology Journal, Volume 14, Issue 1, February 2026.
ABSTRACT Background and aims No medications are currently approved for the prevention of recurrent acute pancreatitis. This trial evaluated whether naldemedine, a peripherally acting μ‐opioid receptor antagonist, reduces the risk of acute pancreatitis in patients with recurrent acute pancreatitis. Methods This was a multicentre, double‐blinded, placebo‐
Mathias E. Cook, Cecilie S. Knoph, Line Davidsen, Jens B. Frøkjær, Niels H. Bruun, Srdan Novovic, Amer Hadi, Maiken Thyregod Jørgensen, Michael B. Mortensen, Ove Schaffalitzky, Liv B. J. Nielsen, Mark Berner‐Hansen, Asbjørn M. Drewes, Søren S. Olesen   +13 more
wiley   +1 more source

An endogenous opioid circuit determines state-dependent reward consumption. [PDF]

Nature, 2021
Castro DC, Oswell CS, Zhang ET, Pedersen CE, Piantadosi SC, Rossi MA, Hunker AC, Guglin A, Morón JA, Zweifel LS, Stuber GD, Bruchas MR.   +11 more
europepmc   +1 more source

[316] ENDOGENOUS OPIOIDS MODULATE HEPATOCYTES APOPTOSIS IN RAT MODEL OF CHRONIC CHOLESTASIS: THE ROLE OF OXIDATIVE STRESS

, 2007
S. Payabvash, Saman Kiumehr, Behtash Ghazinezami, Ali Zandieh, Parisa Anvari, Seyed Mohammad Tavangar, Ahmad Reza Dehpour   +6 more
openalex   +1 more source

Participation of endogenous opioids in the antinociception induced by resistance exercise in rats [PDF]

, 2010
Giovane Galdino, Igor Dimitri Gama Duarte, Andréa C. Perez   +2 more
openalex   +1 more source

Intergenerational transmission of maternal childhood maltreatment, prenatal substance exposure, and internalizing and externalizing symptoms in early adolescence at age 12

Journal of Child Psychology and Psychiatry, Volume 67, Issue 2, Page 171-182, February 2026.
Background Few studies have examined the intergenerational impact of maternal childhood maltreatment (MCM) in the context of prenatal substance exposure (PSE). This study investigates whether PSE is part of the pathway of MCM or an independent risk factor affecting offspring psychopathology.
Meeyoung O. Min, June‐Yung Kim, Sonia Minnes, Rosa Kim, Lynn T. Singer   +4 more
wiley   +1 more source

The Central Reinforcing Properties of Ethanol Are Mediated by Endogenous Opioid Systems: Effects of Mu and Kappa Opioid Antagonists.

Revista Argentina de Ciencias del Comportamiento, 2009
Endogenous opioid systems are implicated in the reinforcing effects of ethanol and may play a substantial role in modulating the central reinforcing effects of ethanol early in ontogeny.
Norman E. Spear, Elena I. Varlinskaya, Michael E Nizhnikov   +2 more
doaj  

Shared Pain, Common Purpose: How Shared Problem Status Drives Congressional Collaboration on Opioid Legislation

Legislative Studies Quarterly, Volume 51, Issue 1, February 2026.
ABSTRACT Why do members of Congress collaborate on legislation in an era of intense partisan polarization? This paper argues that shared exposure to pressing, district‐level policy problems can motivate cross‐party collaboration, particularly in a policy area that cuts across traditional ideological divides. Focusing on the case of the opioid crisis, I
Robert J. McGrath
wiley   +1 more source

Pathogenic Gαo Mutants Drive Dominant GPCR Coupling in GNAO1 Encephalopathies

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Mutations in GNAO1, the gene encoding Gαo, are associated with a wide range of neurodevelopmental disorders. In this study, we show that Gαo variants linked to the most severe patient phenotypes fail to disengage from activated Gi/o‐coupled GPCRs, thereby blocking GRK‐mediated receptor phosphorylation and internalization.
Yonika A. Larasati, Camille Rabesahala de Meritens, Miriam Stoeber, Vladimir L. Katanaev, Gonzalo P. Solis   +4 more
wiley   +1 more source

Effects of placebo administration on immune mechanisms and relationships with central endogenous opioid neurotransmission. [PDF]

Mol Psychiatry, 2022
Prossin A, Koch A, Campbell P, Laumet G, Stohler CS, Dantzer R, Zubieta JK.   +6 more
europepmc   +1 more source

Review for "Timing of treatment with an endogenous opioid alters immune response and spinal cord pathology in female mice with experimental autoimmune encephalomyelitis"

, 2021
Bradley K. Taylor
openalex   +1 more source