Angiotensin-converting enzyme gates brain circuit-specific plasticity via an endogenous opioid. [PDF]
Science, 2022 Angiotensin-converting enzyme (ACE) regulates blood pressure by cleaving angiotensin I to produce angiotensin II. In the brain, ACE is especially abundant in striatal tissue, but the function of ACE in striatal circuits remains poorly understood.
Trieu BH +13 more
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Visualizing endogenous opioid receptors in living neurons using ligand-directed chemistry
eLife, 2019 Identifying neurons that have functional opioid receptors is fundamental for the understanding of the cellular, synaptic and systems actions of opioids. Current techniques are limited to post hoc analyses of fixed tissues. Here we developed a fluorescent
Seksiri Arttamangkul +8 more
doaj +2 more sources
Perspectives on Endogenous Opioids in Birds
Frontiers in Physiology, 2018 The present review summarizes the state of knowledge of endogenous opioids in birds. Endogenous opioid peptides acts in a neuromodulatory, hormonal and paracrine manner to mediate analgesic and other physiological functions.
Colin G. Scanes +1 more
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Nicotine Effects and the Endogenous Opioid System
Journal of Pharmacological Sciences, 2014 .: Nicotine (NIC) is an exogenous ligand of the nicotinic acetylcholine receptor (nAChR), and it influences various functions in the central nervous system. Systemic administration of NIC elicits the release of endogenous opioids (endorphins, enkephalins,
Shiroh Kishioka +3 more
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The role of endogenous opioid neuropeptides in neurostimulation-driven analgesia. [PDF]
Front Syst Neurosci, 2022 Due to the prevalence of chronic pain worldwide, there is an urgent need to improve pain management strategies. While opioid drugs have long been used to treat chronic pain, their use is severely limited by adverse effects and abuse liability ...
Lubejko ST +5 more
europepmc +2 more sources
Frontiers in Pediatrics, 2018 The endogenous opioid system, comprised of multiple opioid neuropeptide and receptor gene families, is highly expressed by developing neural cells and can significantly influence neuronal and glial maturation. In many central nervous system (CNS) regions,
Kurt F. Hauser +5 more
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In Vivo Regulation of the μ Opioid Receptor: Role of the Endogenous Opioid Agents
Molecular Medicine, 2013 It is well known that genotypic differences can account for the subject-specific responses to opiate administration. In this regard, the basal activity of the endogenous system (either at the receptor or ligand level) can modulate the effects of ...
Veronica Gonzalez-Nunez +3 more
doaj +2 more sources
Distinct roles of exogenous opioid agonists and endogenous opioid peptides in the peripheral control of neuropathy-triggered heat pain [PDF]
Scientific Reports, 2016 Neuropathic pain often results from peripheral nerve damage, which can involve immune response. Local leukocyte-derived opioid peptides or exogenous opioid agonists inhibit neuropathy-induced mechanical hypersensitivity in animal models.
Celik, Melih O. +3 more
core +2 more sources
An endogenous opioid circuit determines state-dependent reward consumption. [PDF]
Nature, 2021 Castro DC +11 more
europepmc +2 more sources
Regulation of Opioid Receptors by Their Endogenous Opioid Peptides. [PDF]
Cell Mol Neurobiol, 2021 Gupta A +8 more
europepmc +2 more sources