Results 191 to 200 of about 74,218 (327)

Rethinking Strategies for a Pharmaceutical Approach to Pain Related to Connective Tissue–Related Raynaud Phenomenon in the United States

Arthritis Care &Research, Volume 78, Issue 1, Page 106-112, January 2026.
Objective There are no US Food and Drug Administration–approved therapies for Raynaud phenomenon (RP) in the United States. Clinical trials have been challenged by study design. Important advances in RP patient‐reported outcome measures and mechanistic quantification allow RP‐related pain characterization.
Tracy M. Frech, Charles G. Frech, W. David Merryman, Andrew Sternlicht, Justin Baba   +4 more
wiley   +1 more source

Hypermethylation of OPRM1: Deregulation of the Endogenous Opioid Pathway in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia. [PDF]

Int J Mol Sci
Wyns A, Hendrix J, Van Campenhout J, Buntinx Y, Xiong HY, De Bruyne E, Godderis L, Nijs J, Rice D, Chiang D, Polli A.   +10 more
europepmc   +1 more source

Tobacco withdrawal increases junk food intake: The role of the endogenous opioid system. [PDF]

Drug Alcohol Depend, 2021
Anker JJ, Nakajima M, Raatz S, Allen S, al'Absi M.   +4 more
europepmc   +1 more source

Body Biofluids for Minimally‐Invasive Diagnostics: Insights, Challenges, Emerging Technologies, and Clinical Potential

Advanced Healthcare Materials, Volume 15, Issue 4, 26 January 2026.
Recent advances in diagnostics have accelerated the development of miniaturized wearable technologies for the continuous monitoring of diseases. This paradigm is shifting healthcare away from invasive, centralized blood tests toward decentralized monitoring, using alternative body biofluids.
Lanka Tata Rao, Chandan Kumar Mandal, Fernando Patolsky   +2 more
wiley   +1 more source

The Role of the Endogenous Opioid System in the Vocal Behavior of Songbirds and Its Possible Role in Vocal Learning. [PDF]

Front Physiol, 2022
Singh UA, Iyengar S.
europepmc   +1 more source

Extracellular Vesicles Derived From Mesenchymal Bone Marrow Cells Promote Antinociception in a Murine Model of Diabetic Neuropathy via the Endogenous Opioid System

Advanced Therapeutics, Volume 9, Issue 1, January 2026.
This study investigates the analgesic potential of extracellular vesicles derived from bone marrow mesenchymal stem cells (EV‐BMSC) in diabetic sensory neuropathy. EV‐BMSC reproduce the pain‐relieving effects of BMSC transplantation through opioid‐mediated mechanisms, highlighting a promising cell‐free therapeutic approach for neuropathic pain ...
Gessica S. A. Silva, Afrânio F. Evangelista, Girlaine C. Santos, Thaís A. Santana, Luiza C. F. Opretzka, Pedro S. S. Lauria, Marco A. Stimamiglio, Milena B. P. Soares, Cristiane F. Villarreal   +8 more
wiley   +1 more source

Fentanyl exposure during preconception and gestation permanently dysregulates endogenous opioid peptides and sympathoadrenal-medullary axis in the offspring. [PDF]

Clin Sci (Lond)
Ahmed N, Dalmasso C, Tavakoli NS, Peñalver Abed P, Turner MB, Czuba LC, Pautassi RM, Ortinski PI, Loria AS.   +8 more
europepmc   +1 more source

Central administration of human opiorphin alleviates dextran sodium sulfate-induced colitis in mice through activation of the endogenous opioid system. [PDF]

Front Pharmacol, 2022
Luo P, Li X, Gao Y, Chen Z, Zhang Q, Wang Z, Tian X.   +6 more
europepmc   +1 more source

The Potential Role of the Endogenous Opioid System in the Antidepressant Effect of Ketamine [PDF]

, 2014
Botros Shenoda
openalex   +1 more source

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source