Results 21 to 30 of about 783,260 (291)

Effects of placebo administration on immune mechanisms and relationships with central endogenous opioid neurotransmission. [PDF]

Mol Psychiatry, 2022
Prossin A, Koch A, Campbell P, Laumet G, Stohler CS, Dantzer R, Zubieta JK.   +6 more
europepmc   +3 more sources

Engaging endogenous opioid circuits in pain affective processes. [PDF]

J Neurosci Res, 2022
The pervasive use of opioid compounds for pain relief is rooted in their utility as one of the most effective therapeutic strategies for providing analgesia.
Kimmey BA, McCall NM, Wooldridge LM, Satterthwaite TD, Corder G.   +4 more
europepmc   +2 more sources

Biased signaling by endogenous opioid peptides. [PDF]

Proc Natl Acad Sci U S A, 2020
Significance There are >20 different endogenous opioid peptides derived from the three precursors proopiomelanocortin, proenkephalin, and prodynorphin; a long-standing question is the biological utility of having this variety of peptides.
Gomes I, Sierra S, Lueptow L, Gupta A, Gouty S, Margolis EB, Cox BM, Devi LA.   +7 more
europepmc   +2 more sources

Stress-Induced Changes in the Endogenous Opioid System Cause Dysfunction of Pain and Emotion Regulation

International Journal of Molecular Sciences, 2023
Early life stress, such as child abuse and neglect, and psychosocial stress in adulthood are risk factors for psychiatric disorders, including depression and anxiety.
K. Nakamoto, S. Tokuyama
semanticscholar   +1 more source

Endogenous Opioid Signaling in the Mouse Retina Modulates Pupillary Light Reflex. [PDF]

Int J Mol Sci, 2021
Cleymaet AM, Berezin CT, Vigh J.
europepmc   +3 more sources

Endogenous opioid peptides in the descending pain modulatory circuit. [PDF]

Neuropharmacology, 2020
Bagley EE, Ingram SL.
europepmc   +2 more sources

Endogenous Opioid Peptides and Alternatively Spliced Mu Opioid Receptor Seven Transmembrane Carboxyl-Terminal Variants

International Journal of Molecular Sciences, 2021
There exist three main types of endogenous opioid peptides, enkephalins, dynorphins and β-endorphin, all of which are derived from their precursors. These endogenous opioid peptides act through opioid receptors, including mu opioid receptor (MOR), delta ...
Anna Abrimian, Tamar T. Kraft, Ying-Xian Pan   +2 more
semanticscholar   +1 more source

Opioidergic pathways and kisspeptin in the regulation of female reproduction in mammals

Frontiers in Neuroscience, 2022
Endogenous opioid peptides have attracted attention as critical neuropeptides in the central mechanism regulating female reproduction ever since the discovery that arcuate dynorphin neurons that coexpress kisspeptin and neurokinin B (NKB), which are also
Yoshihisa Uenoyama, Hitomi Tsuchida, Mayuko Nagae, Naoko Inoue, Hiroko Tsukamura   +4 more
doaj   +1 more source

Cellular and circuit diversity determines the impact of endogenous opioids in the descending pain modulatory pathway

Frontiers in Systems Neuroscience, 2022
The descending pain modulatory pathway exerts important bidirectional control of nociceptive inputs to dampen and/or facilitate the perception of pain. The ventrolateral periaqueductal gray (vlPAG) integrates inputs from many regions associated with the ...
Kylie B. McPherson, Kylie B. McPherson, Susan L. Ingram   +2 more
doaj   +1 more source

Different neuronal populations mediate inflammatory pain analgesia by exogenous and endogenous opioids

eLife, 2020
Mu-opioid receptors (MORs) are crucial for analgesia by both exogenous and endogenous opioids. However, the distinct mechanisms underlying these two types of opioid analgesia remain largely unknown.
Xin-Yan Zhang, Yan-Nong Dou, Lei Yuan, Qing Li, Yan-Jing Zhu, Meng Wang, Yan-Gang Sun   +6 more
doaj   +1 more source