Results 31 to 40 of about 783,260 (291)

Liraglutide Activates Glucagon-Like Peptide 1 Receptor to Attenuate Hyperglycemia through Endogenous Beta-Endorphin in Diabetic Rats

open access: yesPharmaceuticals, 2020
Liraglutide, an acylated analog of glucagon-like peptide 1 (GLP-1), could improve glycemic control in diabetes. Moreover, endogenous opioid peptides play a role in blood sugar regulation.
Kai-Chun Cheng   +4 more
doaj   +1 more source

The effect of blood flow restriction exercise on exercise-induced hypoalgesia and endogenous opioid and endocannabinoid mechanisms of pain modulation.

open access: yesJournal of applied physiology, 2020
AIM This study aimed to investigate and compare the magnitude of exercise-induced hypoalgesia (EIH) with low intensity blood flow restriction (BFR) resistance exercise (RE) at varying pressures to other intensities of resistance exercise and examine ...
L. Hughes, S. Patterson
semanticscholar   +1 more source

Crosstalk between Opioid and Anti-Opioid Systems: An Overview and Its Possible Therapeutic Significance

open access: yesBiomolecules, 2020
Opioid peptides and receptors are broadly expressed throughout peripheral and central nervous systems and have been the subject of intense long-term investigations.
Ewa Gibula-Tarlowska   +1 more
doaj   +1 more source

An opioid-like system regulating feeding behavior in C. elegans [PDF]

open access: yes, 2015
Neuropeptides are essential for the regulation of appetite. Here we show that neuropeptides could regulate feeding in mutants that lack neurotransmission from the motor neurons that stimulate feeding muscles. We identified nlp-24 by an RNAi screen of 115
Artyukhin, Alexander B.   +3 more
core   +3 more sources

Opioid regulation of Mu receptor internalisation: relevance to the development of tolerance and dependence [PDF]

open access: yes, 2010
Internalisation of the mu opioid receptor from the surface of cells is generally achieved by receptor occupancy with agonist ligands of high efficacy. However, in many situations the potent analgesic morphine fails to promote internalisation effectively ...
Lopez-Gimenez, J.F., Milligan, G.
core   +2 more sources

Peripherally Acting Opioids in Orofacial Pain

open access: yesFrontiers in Neuroscience, 2021
The activation of opioid receptors by exogenous or endogenous opioids can produce significant analgesic effects in peripheral tissues. Numerous researchers have demonstrated the expression of peripheral opioid receptors (PORs) and endogenous opioid ...
Qing Liu   +10 more
doaj   +1 more source

The Central Reinforcing Properties of Ethanol Are Mediated by Endogenous Opioid Systems: Effects of Mu and Kappa Opioid Antagonists.

open access: greenRevista Argentina de Ciencias del Comportamiento, 2009
Endogenous opioid systems are implicated in the reinforcing effects of ethanol and may play a substantial role in modulating the central reinforcing effects of ethanol early in ontogeny.
Norman E. Spear   +2 more
doaj   +1 more source

Effects of naltrexone on pain sensitivity and mood in fibromyalgia: no evidence for endogenous opioid pathophysiology. [PDF]

open access: yesPLoS ONE, 2009
The pathophysiological mechanisms underlying fibromyalgia are still unknown, although some evidence points to endogenous opioid dysfunction. We examined how endogenous opioid antagonism affects pain and mood for women with and without fibromyalgia.
Jarred W Younger   +2 more
doaj   +1 more source

The Effects of Repeated Morphine Treatment on the Endogenous Cannabinoid System in the Ventral Tegmental Area

open access: yesFrontiers in Pharmacology, 2021
The therapeutic utility of opioids is diminished by their ability to induce rewarding behaviors that may lead to opioid use disorder. Recently, the endogenous cannabinoid system has emerged as a hot topic in the study of opioid reward but relatively ...
Hong Zhang   +8 more
doaj   +1 more source

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