Barriers to infection of human cells by feline leukemia virus: insights into resistance to zoonosis [PDF]
, 2017 The human genome displays a rich fossil record of past gamma-retrovirus infections, yet no current epidemic is evident, despite environmental exposure to viruses that infect human cells in vitro.
Ahmad, Shamim +9 more
core +1 more source
Retrovirus insertion site analysis of LGL leukemia patient genomes
BMC Medical Genomics, 2019 Background Large granular lymphocyte (LGL) leukemia is an uncommon cancer characterized by sustained clonal proliferation of LGL cells. Antibodies reactive to retroviruses have been documented in the serum of patients with LGL leukemia.
Weiling Li +8 more
doaj +1 more source
Virology, 2003 The chronic shortage of human donor organs and tissues for allotransplantation could be relieved if clinical xenotransplantation were to become a viable clinical therapy. Balanced against the benefits of xenotransplantation are the possible consequences of zoonotic infections, and in particular, infection by porcine endogenous retrovirus (PERV).
Suling, Kristen +3 more
openaire +2 more sources
Scar Inhibition in Wound Healing: Mechanisms, Design, and Recent Advances
Exploration, EarlyView.This review elaborates on current research on immune modulation in tissue regeneration, emphasizing the roles of proinflammatory and anti‐inflammatory cells. This review also explored the potential of biomaterials for modulating the wound environment to promote scarless healing.
Yong Kang +4 more
wiley +1 more source
Transposable Elements, Inflammation, and Neurological Disease. [PDF]
, 2019 Transposable Elements (TE) are mobile DNA elements that can replicate and insert themselves into different locations within the host genome. Their propensity to self-propagate has a myriad of consequences and yet their biological significance is not well-
Macia, Angela +2 more
core
Retroviral replicating vector-mediated gene therapy achieves long-term control of tumor recurrence and leads to durable anticancer immunity. [PDF]
, 2017 BackgroundProdrug-activator gene therapy with Toca 511, a tumor-selective retroviral replicating vector (RRV) encoding yeast cytosine deaminase, is being evaluated in recurrent high-grade glioma patients.
Gruber, Harry E +14 more
core +1 more source
Dot1l cooperates with Npm1 to repress endogenous retrovirus MERVL in embryonic stem cells [PDF]
, 2023 Xin Zhao +8 more
openalex +1 more source
Detecting Endogenous Retrovirus-Driven Tissue-Specific Gene Transcription [PDF]
Genome Biology and Evolution, 2015 Transposable elements (TEs) comprise approximately half of the human genome, and several independent lines of investigation have demonstrated their role in rewiring gene expression during development, evolution, and oncogenesis. The identification of their regulatory effects has largely been idiosyncratic, by linking activity with isolated genes. Their
Pavlicev, Mihaela +4 more
openaire +2 more sources
Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells. [PDF]
, 2019 Chromatin architecture has been implicated in cell type-specific gene regulatory programs, yet how chromatin remodels during development remains to be fully elucidated.
Amaral, Maria Luisa +21 more
core +2 more sources
Human Endogenous Retrovirus K (HML-2) in Health and Disease
Frontiers in Microbiology, 2020 Human endogenous retroviruses (HERVs) are derived from exogenous retrovirus infections in the evolution of primates and account for about 8% of the human genome.
Bei Xue +6 more
doaj +1 more source