Results 81 to 90 of about 73,519 (232)
Transposable Elements, Inflammation, and Neurological Disease. [PDF]
, 2019 Transposable Elements (TE) are mobile DNA elements that can replicate and insert themselves into different locations within the host genome. Their propensity to self-propagate has a myriad of consequences and yet their biological significance is not well-
Macia, Angela +2 more
core
Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells. [PDF]
, 2019 Chromatin architecture has been implicated in cell type-specific gene regulatory programs, yet how chromatin remodels during development remains to be fully elucidated.
Amaral, Maria Luisa +21 more
core +2 more sources
Virology, 2003 The chronic shortage of human donor organs and tissues for allotransplantation could be relieved if clinical xenotransplantation were to become a viable clinical therapy. Balanced against the benefits of xenotransplantation are the possible consequences of zoonotic infections, and in particular, infection by porcine endogenous retrovirus (PERV).
Suling, Kristen +3 more
openaire +2 more sources
Retroviral replicating vector-mediated gene therapy achieves long-term control of tumor recurrence and leads to durable anticancer immunity. [PDF]
, 2017 BackgroundProdrug-activator gene therapy with Toca 511, a tumor-selective retroviral replicating vector (RRV) encoding yeast cytosine deaminase, is being evaluated in recurrent high-grade glioma patients.
Gruber, Harry E +14 more
core +1 more source
Detecting Endogenous Retrovirus-Driven Tissue-Specific Gene Transcription [PDF]
Genome Biology and Evolution, 2015 Transposable elements (TEs) comprise approximately half of the human genome, and several independent lines of investigation have demonstrated their role in rewiring gene expression during development, evolution, and oncogenesis. The identification of their regulatory effects has largely been idiosyncratic, by linking activity with isolated genes. Their
Pavlicev, Mihaela +4 more
openaire +2 more sources
Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing
Small, EarlyView.The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa +4 more
wiley +1 more source
Frontiers in Cellular and Infection Microbiology, 2016 Avian leukosis virus subgroup J (ALV-J) infection can cause tumors and immunosuppression. Endogenous viruses integrate into host genomes and can recombine with exogenous avian leukosis virus (ALV). In this study, we analyzed the interaction of endogenous
Min Feng +7 more
doaj +1 more source
Human Endogenous Retrovirus K (HML-2) in Health and Disease
Frontiers in Microbiology, 2020 Human endogenous retroviruses (HERVs) are derived from exogenous retrovirus infections in the evolution of primates and account for about 8% of the human genome.
Bei Xue +6 more
doaj +1 more source
Potential benefits and risks of clinical xenotransplantation [PDF]
, 2012 The transplantation of organs and cells from pigs into humans could overcome the critical and continuing problem of the lack of availability of deceased human organs and cells for clinical transplantation.
Ayares, D, Cooper, DKC
core +2 more sources
Human endogenous retrovirus K10 encodes a functional integrase [PDF]
Journal of Virology, 1996 We cloned a human endogenous retrovirus K1O DNA fragment encoding integrase and expressed it as a fusion protein with Escherichia coli maltose-binding protein. Integrase activities were measured in vitro by using a double-stranded oligonucleotide as a substrate mimicking viral long terminal repeats (LTR).
Y, Kitamura +4 more
openaire +2 more sources