Results 81 to 90 of about 604,863 (290)

Mouse strain-specific polymorphic provirus functions as cis-regulatory element leading to epigenomic and transcriptomic variations

Nature Communications, 2021
How polymorphic elements can drive intra-species variation has not been clearly examined. Here the authors show that the polymorphic GLN endogenous retrovirus (ERV) functions as a cis-regulatory element for neighboring genes, leading to differences in ...
Xuemeng Zhou, Tsz Wing Sam, Ah Young Lee, Danny Leung   +3 more
doaj   +1 more source

Genome-Wide Characterization of Zebrafish Endogenous Retroviruses Reveals Unexpected Diversity in Genetic Organizations and Functional Potentials

Microbiology Spectrum, 2021
Endogenous retroviruses (ERVs) occupy a substantial fraction of mammalian genomes. However, whether ERVs extensively exist in ancient vertebrates remains unexplored.
Jun Bai, Zuo-zhen Yang, Hao Li, Yun Hong, Dong-dong Fan, Ai-fu Lin, Li-xin Xiang, Jian-zhong Shao   +7 more
doaj   +1 more source

Endogenous retrovirus expression is associated with response to immune checkpoint blockade in clear cell renal cell carcinoma.

JCI Insight, 2018
Although a subset of clear cell renal cell carcinoma (ccRCC) patients respond to immune checkpoint blockade (ICB), predictors of response remain uncertain.
Anshuman Panda, Aguirre A. de Cubas, M. Stein, G. Riedlinger, Joshua Kra, T. Mayer, Christof C. Smith, B. Vincent, J. Serody, Katherine E. Beckermann, S. Ganesan, G. Bhanot, W. Rathmell   +12 more
semanticscholar   +1 more source

Establishment of Interspecies Somatic Cell Nuclear Transfer and Transgene‐Free Inducible Pluripotent Stem Cells for Versatile Conservation of the Germplasm Resource of Wild Boar

Animal Research and One Health, EarlyView.
Conserving genetic material and even increasing genetic diversity is critical. To conduct the conservation of wild boar germplasm resources, we have successfully obtained healthy cloned wild boars for the first time using interspecies somatic cell nuclear transfer and established transgene‐free iPSCs that can be used to conduct iterative rounds of gene
Chen Gao, Xinyi Zhou, Shigang Gu, Jianbo Li, Jing Wang, Yurong Zhang, Wenxuan Zhao, Xinhua Wei, Liting Lu, Quanmin Zhao, Yongye Huang, Dawei Yu   +11 more
wiley   +1 more source

RNA-dependent chromatin targeting of TET2 for endogenous retrovirus control in pluripotent stem cells

Nature Genetics, 2018
Ten-eleven translocation (TET) proteins play key roles in the regulation of DNA-methylation status by oxidizing 5-methylcytosine (5mC) to generate 5-hydroxymethylcytosine (5hmC), which can both serve as a stable epigenetic mark and participate in active ...
Diana Guallar, Xianju Bi, José Ángel Pardavila, Xin Huang, Carmen Sáenz, Xianle Shi, Hongwei Zhou, F. Faiola, Junjun Ding, P. Haruehanroengra, Fan Yang, Dan Li, Carlos Sanchez-Priego, Arven H Saunders, Feng Pan, V. Valdes, K. Kelley, Miguel G. Blanco, Lingyi Chen, Huayan Wang, J. Sheng, Mingjiang Xu, Miguel Fidalgo, Xiaohua Shen, Jianlong Wang   +24 more
semanticscholar   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Sequences, annotation and single nucleotide polymorphism of the major histocompatibility complex in the domestic cat.

PLoS ONE, 2008
Two sequences of major histocompatibility complex (MHC) regions in the domestic cat, 2.976 and 0.362 Mbps, which were separated by an ancient chromosome break (55-80 MYA) and followed by a chromosomal inversion were annotated in detail.
Naoya Yuhki, James C Mullikin, Thomas Beck, Robert Stephens, Stephen J O'Brien   +4 more
doaj   +1 more source

Acquisition and Exaptation of Endogenous Retroviruses in Mammalian Placenta

Biomolecules, 2023
Endogenous retroviruses (ERVs) are retrovirus-like sequences that were previously integrated into the host genome. Although most ERVs are inactivated by mutations, deletions, or epigenetic regulation, some remain transcriptionally active and impact host ...
Sayumi Shimode
doaj   +1 more source

Inhibition of budding/release of porcine endogenous retrovirus [PDF]

Microbiology and Immunology, 2014
AbstractPERV is integrated into the genome of all pigs. PERV‐A and PERV‐B are polytropic and can productively infect human cell lines, whereas PERV‐C is ecotropic. Recombinant PERV‐A/C can infect human cells and exhibits high titer replication. Therefore, use of pigs for human xenotransplantation raises concerns about the risks of transfer of this ...
Masumi, Abe, Aiko, Fukuma, Rokusuke, Yoshikawa, Takayuki, Miyazawa, Jiro, Yasuda   +4 more
openaire   +2 more sources

Alu Overexpression Leads to an Increased Double‐Stranded RNA Signature in Dermatomyositis

Arthritis &Rheumatology, EarlyView.
Objective Dermatomyositis is an autoimmune condition characterized by a high interferon signature of unknown etiology. Because coding sequences constitute <1.2% of our genomes, there is a need to explore the role of the noncoding genome in disease pathogenesis.
Rayan Najjar, Andrew Mammen, Tomas Mustelin   +2 more
wiley   +1 more source