Results 71 to 80 of about 132,565 (303)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Endogenous Timing in a Mixed Duopoly: The Managerial Delegation Case [PDF]
We introduce managerial delegation into Pal's (1998) model and examine the impact of the introduction of managerial delegation on endogenous timing in a mixed duopolistic model for differentiated goods.
Tomohiro Inoue, Yasuhiko Nakamura
core
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
A Note on Endogenous Timing with Strategic Delegation: Unilateral Externality Case [PDF]
We investigated the endogenous choice of roles by managerial firms in the presence of unilateral externality. The choice over timing can be taken either by managers or by owners.
Kangsik Choi, Yuanzhu Lu
core
Optimal Temporal Risk Assessment
Frontiers in Integrative Neuroscience, 2011 Time is an essential feature of most decisions. Keeping track of time is adaptive because the reward earned from decisions frequently depends on the temporal statistics of the environment.
Fuat eBalcı +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Endogenous Timing in a Mixed Oligopoly with Foreign Competitors [PDF]
Endogenous order of moves in quantity choice is analyzed in a mixed oligopoly with one public firm, n domestic private firms and m foreign private firms.
Yuanzhu Lu
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Endogenous timing in a mixed oligopoly consisting of a single public firm and foreign competitors [PDF]
We investigate endogenous timing in a mixed oligopoly consisting of a single public firm and foreign competitors and compare the results with those in Pal (1998) to see the effect of the nationality of private firms on the endogenous role of the public ...
Yuanzhu Lu
core