Evolutionary analysis of endogenous intronic retroviruses in primates reveals an enrichment in transcription binding sites associated with key regulatory processes [PDF]
PeerJ, 2022 Background Endogenous retroviruses (ERVs) are the result of the integration of retroviruses into host DNA following germline infection. Endogenous retroviruses are made up of three main genes: gag, pol, and env, each of which encodes viral proteins that ...
Melissa Calero-Layana +4 more
doaj +2 more sources
Assessing the Diversity of Endogenous Viruses Throughout Ant Genomes
Frontiers in Microbiology, 2019 Endogenous viral elements (EVEs) can play a significant role in the evolution of their hosts and have been identified in animals, plants, and fungi.
Peter J. Flynn +3 more
doaj +1 more source
ViralRecall—A Flexible Command-Line Tool for the Detection of Giant Virus Signatures in ‘Omic Data
Viruses, 2021 Giant viruses are widespread in the biosphere and play important roles in biogeochemical cycling and host genome evolution. Also known as nucleo-cytoplasmic large DNA viruses (NCLDVs), these eukaryotic viruses harbor the largest and most complex viral ...
Frank O. Aylward, Mohammad Moniruzzaman
doaj +1 more source
Deep-mining of vertebrate genomes reveals an unexpected diversity of endogenous viral elements
, 2023 AbstractEndogenous viral elements (EVEs) are key to our understanding of the diversity, host range and evolutionary history of viruses. Given the increasing amounts of virus and host sequence data, a systematic search for EVEs is becoming computationally challenging.
Barreat JGN, Katzourakis A.
europepmc +2 more sources
Emerging connections between small RNAs and phytohormones [PDF]
, 2020 Small RNAs (sRNAs), mainly including miRNAs and siRNAs, are ubiquitous in eukaryotes. sRNAs mostly negatively regulate gene expression via (post-)transcriptional gene silencing through DNA methylation, mRNA cleavage, or translation inhibition.
Dubois, Marieke +3 more
core +2 more sources
Viruses and Endogenous Retroviruses as Roots for Neuroinflammation and Neurodegenerative Diseases
Frontiers in Neuroscience, 2021 Many neurodegenerative diseases are associated with chronic inflammation in the brain and periphery giving rise to a continuous imbalance of immune processes.
Christine Römer
doaj +1 more source
Domestic chickens activate a piRNA defense against avian leukosis virus [PDF]
, 2017 PIWI-interacting RNAs (piRNAs) protect the germ line by targeting transposable elements (TEs) through the base-pair complementarity. We do not know how piRNAs co-evolve with TEs in chickens.
Anai +124 more
core +2 more sources
Frontiers in Microbiology, 2018 RNA interference (RNAi)-based antiviral defense generates small interfering RNAs that represent the entire genome sequences of both RNA and DNA viruses as well as viroids and viral satellites.
Mikhail M. Pooggin
doaj +1 more source
Viral delivery of antioxidant genes as a therapeutic strategy in experimental models of amyotrophic lateral sclerosis. [PDF]
, 2013 Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder with no effective treatment to date. Despite its multi-factorial aetiology, oxidative stress is hypothesized to be one of the key pathogenic mechanisms.
Azzouz, M +6 more
core +1 more source
An Endogenous Foamy-like Viral Element in the Coelacanth Genome
PLoS Pathogens, 2012 Little is known about the origin and long-term evolutionary mode of retroviruses. Retroviruses can integrate into their hosts' genomes, providing a molecular fossil record for studying their deep history. Here we report the discovery of an endogenous foamy virus-like element, which we designate 'coelacanth endogenous foamy-like virus' (CoeEFV), within ...
Guan-Zhu Han, Michael Worobey
openaire +4 more sources