Results 41 to 50 of about 3,677 (204)

Epithelial cell stretching and luminal acidification lead to a retarded development of stria vascularis and deafness in mice lacking pendrin. [PDF]

PLoS ONE, 2011
Loss-of-function mutations of SLC26A4/pendrin are among the most prevalent causes of deafness. Deafness and vestibular dysfunction in the corresponding mouse model, Slc26a4(-/-), are associated with an enlargement and acidification of the membranous ...
Hyoung-Mi Kim, Philine Wangemann
doaj   +1 more source

Comparison of the Pathway to the Inner Ear Between Postauricular and Intramuscular Injection of Dexamethasone in Guinea Pigs

Frontiers in Neurology, 2022
BackgroundPostauricular injection as a local therapy has been confirmed to be effective for inner ear diseases. However, the mechanism for the drugs entering the inner ears remains unknown.
Aiping Chen, Wenwen Liu, Lei Xu, Zhiqiang Hou, Zhaomin Fan, Haibo Wang, Haibo Wang, Mingming Wang   +7 more
doaj   +1 more source

Endolymphatic sac involvement in bacterial meningitis

, 2015
The commonest sequelae of bacterial meningitis are related to the inner ear. Little is known about the inner ear immune defense. Evidence suggests that the endolymphatic sac provides some protection against infection.
Østergaard, Christian, Brandt, Christian, Caye-Thomasen, Per, Møller, Martin Nue   +3 more
core   +1 more source

Magnetic resonance imaging features of large endolymphatic sac compartments: audiological and clinical correlates [PDF]

, 2012
OBJECTIVES: (1) To study the prevalence and characteristics of large endolymphatic sac internal compartments on thin-section T2- and T2*-weighted magnetic resonance imaging, and to relate these to other large endolymphatic sac magnetic resonance imaging ...
Siddiqui, A, Siddiqui, A., Jiang, Dan, Connor, S. E. J., Lee, A, O'Gorman, R., Tysome, J R, Tysome, J. R., Fitzgerald-O'Connor, A, Fitzgerald O'Connor, Alec, O'Gorman, R; https://orcid.org/, Connor, S E J, Lee, A., Jiang, D   +13 more
core   +1 more source

Surgical Treatment of Lateral Skull Base Tumors Extending to the Craniovertebral Junction

Head &Neck, EarlyView.
ABSTRACT Objective To evaluate the clinical manifestation, surgical strategies, and long‐term outcomes of lateral skull base tumors extending to the craniovertebral junction (CVJ), with a focus on the infratemporal fossa approach (IFA) and individualized treatment options for cervical‐occipital stability.
Songbo Xue, Yang Zhao, Huiying Sun, Hanlin Chen, Yong Zhao, Xin Ding, Wanru Zheng, Fei Ren, Yiwei Zhao, Jiajing Tong, Yu Chen, Zhiqiang Gao, Xu Tian, Siyi Cai, Guodong Feng   +14 more
wiley   +1 more source

Predicting cochlear structural alterations from auditory function in age‐related hearing loss mice based on optical coherence tomography

Journal of Intelligent Medicine, EarlyView.
Abstract With global population aging, age‐related hearing loss has become a major public health concern. Understanding the relationship between auditory functional decline and cochlear structural degeneration is essential for early detection and precise intervention.
Shu Zheng, Zhiqi Li, Junyue Wang, Guangjian Ni   +3 more
wiley   +1 more source

Visualization and clinical relevance of the endolymphatic duct and sac in Ménière's disease

Frontiers in Neurology, 2023
BackgroundMénière's disease (MD) is a chronic inner ear disorder with a multifactorial etiology. Decreased visualization of the endolymphatic duct (ED) and sac (ES) is thought to be associated with MD, although controversy exists about whether this ...
Lisa M. H. de Pont, Lisa M. H. de Pont, Maartje T. P. M. Houben, Maartje T. P. M. Houben, Thijs O. Verhagen, Thijs O. Verhagen, Berit M. Verbist, Mark A. van Buchem, Claire C. Bommeljé, Henk M. Blom, Henk M. Blom, Henk M. Blom, Sebastiaan Hammer   +12 more
doaj   +1 more source

Labyrinthine Abnormalities on MRI in Untreated Otosclerosis: Prevalence and Clinical Relevance

The Laryngoscope, EarlyView.
In untreated otosclerosis with labyrinthine symptoms, delayed 3D FLAIR MRI rarely demonstrates endolymphatic hydrops but frequently reveals blood–labyrinth barrier (BLB) disruption. BLB enhancement is spatially associated with cochlear endosteal and round window involvement and increases with the severity of the hearing loss phenotype.
Héléna Pencroffi, Sylvain Bourdoncle, Jean Fanet, Stéphane Gargula, Denis Ayache, Loïc Duron, Julien Savatovsky, Guillaume Poillon   +7 more
wiley   +1 more source

Ménière's Disease: A Tri‐Decade Scoping Review of Treatment Trends and Evidence Quality

The Laryngoscope, EarlyView.
This tri‐decade scoping review of Ménière's disease literature reveals a significant increase in high‐level evidence and a clinical pivot toward hearing‐preserving interventions, such as intratympanic steroids and cochlear implants. However, a significant quality paradox has emerged, where adherence to standardized AAO‐HNS reporting and diagnostic ...
Ofir Zavdy, Teeraya Piyajarawong, Seamus Boyle, Ross O'Shea, John Rutka   +4 more
wiley   +1 more source

Gentamicin delivery to the inner ear: Does endolymphatic hydrops matter? [PDF]

PLoS ONE, 2018
INTRODUCTION:Middle ear application of gentamicin is a common medical treatment for uncontrolled Ménière's disease. The objective of the study was to evaluate the impact of endolymphatic hydrops on inner ear delivery.
Pedro Marques, Maoli Duan, Nicolas Perez-Fernandez, Jorge Spratley   +3 more
doaj   +1 more source