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The Role of FoxG1 in the Inner Ear

Frontiers in Cell and Developmental Biology, 2020
Sensorineural deafness is mainly caused by damage to the tissues of the inner ear, and hearing impairment has become an increasingly serious global health problem.
Yanyan Ding, Wei Meng, Weijia Kong, Zuhong He, Renjie Chai, Renjie Chai, Renjie Chai, Renjie Chai   +7 more
doaj   +2 more sources

Direct SARS-CoV-2 infection of the human inner ear may underlie COVID-19-associated audiovestibular dysfunction

Communications Medicine, 2021
Plain language summary Coronavirus disease 2019 (COVID-19) is an infectious disease caused by the novel coronavirus SARS-CoV-2. A growing number of sensory symptoms have been linked to this illness.
Minjin Jeong, Karen E. Ocwieja, Dongjun Han, P. Ashley Wackym, Yichen Zhang, Alyssa Brown, Cynthia Moncada, Andrea Vambutas, Theodore Kanne, Rachel Crain, Noah Siegel, Valerie Leger, Felipe Santos, D. Bradley Welling, Lee Gehrke, Konstantina M. Stankovic   +15 more
doaj   +2 more sources

AAV2.7m8 is a powerful viral vector for inner ear gene therapy

Nature Communications, 2019
Adeno-associated virus (AAV) has been successfully used to deliver gene therapy to improve auditory function in mouse models of hereditary hearing loss.
Wade Chien, Jean Bennett, Kevin Isgrig   +2 more
exaly   +2 more sources

Current strategies for drug delivery to the inner ear

Acta Pharmaceutica Sinica B, 2013
For many years, drug delivery to the inner ear has been a challenge to physicians in the treatment of inner ear disorders. In the past decade, the field of inner ear drug delivery has emerged with the development of new biomaterials and drug delivery ...
Hongzhuo Liu
exaly   +3 more sources

Defective Tmprss3-Associated Hair Cell Degeneration in Inner Ear Organoids

Stem Cell Reports, 2019
Summary: Mutations in the gene encoding the type II transmembrane protease 3 (TMPRSS3) cause human hearing loss, although the underlying mechanisms that result in TMPRSS3-related hearing loss are still unclear.
Pei-Ciao Tang, Alpha L. Alex, Jing Nie, Jiyoon Lee, Adam A. Roth, Kevin T. Booth, Karl R. Koehler, Eri Hashino, Rick F. Nelson   +8 more
doaj   +2 more sources

Inner Ear Therapeutics: An Overview of Middle Ear Delivery

Frontiers in Cellular Neuroscience, 2019
There are a variety of methods to access the inner ear and many of these methods depend on utilizing the middle ear as a portal. In this approach the middle ear can be used as a passive receptacle, as part of an active drug delivery system, or simply as ...
Jaimin Patel, Mikhaylo Szczupak, Suhrud Rajguru, Suhrud Rajguru, Carey Balaban, Michael E. Hoffer, Michael E. Hoffer   +6 more
doaj   +2 more sources

A single-cell level comparison of human inner ear organoids with the human cochlea and vestibular organs

Cell Reports, 2023
SUMMARY Inner ear disorders are among the most common congenital abnormalities; however, current tissue culture models lack the cell type diversity to study these disorders and normal otic development.
Wouter H. van der Valk, E. V. van Beelen, Matthew R. Steinhart, Carl Nist-Lund, Daniel Osorio, J. D. de Groot, Liang Sun, P. V. van Benthem, Karl R. Koehler, H. Locher   +9 more
semanticscholar   +1 more source

Refining surgical techniques for efficient posterior semicircular canal gene delivery in the adult mammalian inner ear with minimal hearing loss

Scientific Reports, 2021
Hearing loss is a common disability affecting the world’s population today. While several studies have shown that inner ear gene therapy can be successfully applied to mouse models of hereditary hearing loss to improve hearing, most of these studies rely
Jianliang Zhu, Jin Woong Choi, Yasuko Ishibashi, Kevin Isgrig, Mhamed Grati, Jean Bennett, Wade Chien   +6 more
doaj   +1 more source

Fzd3 Expression Within Inner Ear Afferent Neurons Is Necessary for Central Pathfinding

Frontiers in Neuroscience, 2022
During development the afferent neurons of the inner ear make precise wiring decisions in the hindbrain reflective of their topographic distribution in the periphery.
Zachary A. Stoner, Elizabeth M. Ketchum, Sydney Sheltz-Kempf, Paige V. Blinkiewicz, Karen L. Elliott, Jeremy S. Duncan, Jeremy S. Duncan   +6 more
doaj   +1 more source

Inner ear malformation

Listy klinicke logopedie, 2020
Inner ear malformation comprises a broad group of disorders, the main symptom of which is hearing loss. The disorder occurs during the embryonic development of the auditory system. Only about 20 % of malformations can be diagnosed radiologically. Hearing
Dagmar Hošnová, Milan Urík
doaj   +1 more source