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Inner ear tissue preservation by rapid freezing: Improving fixation by high-pressure freezing and hybrid methods. [PDF]
, 2014 In the preservation of tissues in as 'close to life' state as possible, rapid freeze fixation has many benefits over conventional chemical fixation. One technique by which rapid freeze-fixation can be achieved, high pressure freezing (HPF), has been ...
Taylor, R.R. +12 more
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AAV-ie enables safe and efficient gene transfer to inner ear cells
Nature Communications, 2019 Hearing loss is the most common sensory disorder. While gene therapy has emerged as a promising treatment of inherited diseases like hearing loss, it is dependent on the identification of gene delivery vectors.
Fangzhi Tan +16 more
semanticscholar +1 more source
Development of the inner ear [PDF]
Current Opinion in Genetics & Development, 2015 The vertebrate inner ear is a sensory organ of exquisite design and sensitivity. It responds to sound, gravity and movement, serving both auditory (hearing) and vestibular (balance) functions. Almost all cell types of the inner ear, including sensory hair cells, sensory neurons, secretory cells and supporting cells, derive from the otic placode, one of
openaire +3 more sources
RAF kinase activity regulates neuroepithelial cell proliferation and neuronal progenitor cell differentiation during early inner ear development [PDF]
, 2010 Background: Early inner ear development requires the strict regulation of cell proliferation, survival, migration and differentiation, coordinated by the concerted action of extrinsic and intrinsic factors.
Rapp Ulf R. +21 more
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Biomedicines, 2021 Zebrafish is an excellent model for exploring the development of the inner ear. Its inner ear has similar functions to that of humans, specifically in the maintenance of hearing and balance. Mafba is a component of the Maf transcription factor family. It
Xiang Chen +10 more
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American Journal of Otolaryngology, 1985 Previously the authors proposed that the perilymphatic inner ear immune system is independent of that of the cerebrospinal fluid. In the present study, the effect of dilatation of blood vessels surrounding the cochlea of chinchillas on the transfer of serum antibodies to the perilymph was tested. The possibility of local production of antibodies in the
Kawauchi, H. +3 more
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The Relationship Between the Third Window Abnormalities and Inner Ear Malformations in Children with Hearing Loss [PDF]
, 2021 OBJECTIVE: To evaluate the relationship between the third window abnormalities and congenital inner ear malformations in pediatric patients with different types of hearing loss.
Fatma Ceren Sarioglu +9 more
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Visualization of macrophage subsets in the development of the fetal human inner ear
Frontiers in Immunology, 2022 BackgroundHuman inner ear contains macrophages whose functional role in early development is yet unclear. Recent studies describe inner ear macrophages act as effector cells of the innate immune system and are often activated following acoustic trauma or
Claudia Steinacher +11 more
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Characterization of the Usher Syndrome gene CDH23: implications for mechanosensation in the vertebrate inner ear [PDF]
, 2004 Deafness is the most common form of sensory impairment afflicting the human population. Approximately one in eight hundred children is born with serious hearing impairment and more than half of these cases are likely due to single gene defects.
Siemens, Jan-Erik
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Potential application value of pigment epithelium-derived factor in sensorineural hearing loss
Frontiers in Neuroscience, 2023 The inner ear is a complex and precise auditory perception system responsible for receiving and converting sound signals into neural signals, enabling us to perceive and understand sound.
Zihui Sun +12 more
doaj +1 more source