Results 51 to 60 of about 1,367,224 (352)

A bundle of mechanisms: Inner-ear hair-cell mechanotransduction

Trends in Neurosciences, 2019
In the inner ear, the deflection of hair bundles, the sensory organelles of hair cells, activates mechanically-gated channels (MGCs). Hair bundles monitor the head’s orientation, its angular and linear acceleration, and detect sound.
Dáibhid Ó Maoiléidigh, A. Ricci
semanticscholar   +1 more source

Conditional and constitutive expression of a Tbx1-GFP fusion protein in mice. [PDF]

, 2013
BACKGROUND: Velo-cardio-facial syndrome/DiGeorge syndrome (VCFS/DGS) is caused by a 1.5-3 Mb microdeletion of chromosome 22q11.2, frequently referred to as 22q11.2 deletion syndrome (22q11DS).
Morrow BE, Nowotschin, Sonja, Pirity MK, Baldini, Antonio, Freyer L, Freyer, Laina, Nowotschin S, Pirity, Melinda K., Morrow, Bernice E.   +8 more
core   +1 more source

Next-generation 3D bioprinted inner ear organoids

Biomedical Technology
Background: Inner ear is crucial for maintaining normal functions of human sensory perception. However, current perceptual reconstruction is mostly limited to symptomatic relief and lacks a radical cure for irreversible damage.
Xingyu Chen, Minghong He, Yuexin He, Zhe Li, Renjie Chai   +4 more
doaj   +1 more source

Inner ear delivery: Challenges and opportunities

Laryngoscope Investigative Otolaryngology, 2019
The treatment of inner ear disorders remains challenging due to anatomic barriers intrinsic to the bony labyrinth. The purpose of this review is to highlight recent advances and strategies for overcoming these barriers and to discuss promising future ...
Betsy Szeto, H. Chiang, Chris Valentini, Michelle Yu, J. Kysar, A. Lalwani   +5 more
semanticscholar   +1 more source

Multimodal Atlas of the Murine Inner Ear: From Embryo to Adult

Frontiers in Neurology, 2021
The inner ear is a complex organ housed within the petrous bone of the skull. Its intimate relationship with the brain enables the transmission of auditory and vestibular signals via cranial nerves.
Jean-Paul Bryant, Vikram Chandrashekhar, Vikram Chandrashekhar, Anthony J. Cappadona, Pashayar P. Lookian, Pashayar P. Lookian, Vibhu Chandrashekhar, Danielle R. Donahue, Jeeva B. Munasinghe, H. Jeffrey Kim, H. Jeffrey Kim, Alexander O. Vortmeyer, John D. Heiss, Zhengping Zhuang, Jared S. Rosenblum, Jared S. Rosenblum   +15 more
doaj   +1 more source

Sensory neuron diversity in the inner ear is shaped by activity

Cell, 2018
Summary In the auditory system, Type I spiral ganglion neurons (SGNs) convey complex acoustic information from inner hair cells (IHCs) to the brainstem.
B. R. Shrestha, Chester Chia, Lorna Wu, S. Kujawa, L. Goodrich   +4 more
semanticscholar   +1 more source

Characterizing human vestibular sensory epithelia for experimental studies: new hair bundles on old tissue and implications for therapeutic interventions in ageing. [PDF]

, 2015
Balance disequilibrium is a significant contributor to falls in the elderly. The most common cause of balance dysfunction is loss of sensory cells from the vestibular sensory epithelia of the inner ear.
Daniel J. Jagger, Axon, Patrick, Moffatt, D, Moffatt, David, Jagger, DJ, Tysome, James, Monksfield, Peter, Taylor, Ruth R., Jagger, Daniel J., Peter Monksfield, Donnelly, N, Lloyd, SK, Coulson, Chris, Irving, R, Coulson, C, Freeman, SR, Saeed, Shakeel R., Richard Irving, Simon K. Lloyd, Lloyd, Simon K., Forge, Andrew, Neil Donnelly, Freeman, Simon R., Shakeel R. Saeed, Taylor, RR, David Moffatt, Forge, A, Irving, Richard, Saeed, SR, Axon, P, Ruth R. Taylor, Monksfield, P, Simon R. Freeman, Donnelly, Neil, Chris Coulson, Tysome, J, Andrew Forge, Patrick Axon, James Tysome   +38 more
core   +1 more source

Precision medicine: a new era for inner ear diseases

Frontiers in Pharmacology
The inner ear is the organ responsible for hearing and balance. Inner ear dysfunction can be the result of infection, trauma, ototoxic drugs, genetic mutation or predisposition. Often, like for Ménière disease, the cause is unknown.
Elisa Tavazzani, Elisa Tavazzani, Paolo Spaiardi, Paolo Spaiardi, Donatella Contini, Giulio Sancini, Giulio Sancini, Giancarlo Russo, Sergio Masetto   +8 more
doaj   +1 more source

Macrophage-related immune responses in inner ear: a potential therapeutic target for sensorineural hearing loss

Frontiers in Neuroscience
Hearing loss is the most common sensory disorder in human beings. Cochlear sensory cells are the basis of hearing. Cochlear sensory cells suffer from various acute or chronic injuries, such as excessive sound stimulation, ototoxic drugs, and age-related ...
Yu-Chen Liu, Kai Xu
doaj   +1 more source

Genetic Causes of Inner Ear Anomalies: a Review from the Turkish Study Group for Inner Ear Anomalies

Balkan Medical Journal, 2019
Inner ear anomalies diagnosed using a radiological study are detected in almost 30% of cases with congenital or prelingual-onset sensorineural hearing loss.
Emre Ocak, Duygu Duman, Mustafa Tekin
doaj   +1 more source