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Hair cell loss – cause or consequence of hearing loss? [PDF]
Frontiers in Cell and Developmental BiologyHair cell loss is a major hallmark of hearing loss. Historically, hair cell loss has been considered the major cause of hearing loss. Typically, synapses between hair cells and auditory nerve fibers and stereocilia are lost even before hair cells.
Maurizio Cortada +4 more
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eLife, 2022 Reprogramming of the cochlea with hair-cell-specific transcription factors such as ATOH1 has been proposed as a potential therapeutic strategy for hearing loss.
Amrita A Iyer +15 more
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Current Opinion in Neurobiology, 2008 The mammalian inner ear largely lacks the capacity to regenerate hair cells, the sensory cells required for hearing and balance. Recent studies in both lower vertebrates and mammals have uncovered genes and pathways important in hair cell development and have suggested ways that the sensory epithelia could be manipulated to achieve hair cell ...
Albert Sb, Edge, Zheng-Yi, Chen
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Myc and Fgf Are Required for Zebrafish Neuromast Hair Cell Regeneration. [PDF]
PLoS ONE, 2016 Unlike mammals, the non-mammalian vertebrate inner ear can regenerate the sensory cells, hair cells, either spontaneously or through induction after hair cell loss, leading to hearing recovery.
Sang Goo Lee +11 more
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The role of epigenetic modifications in sensory hair cell development, survival, and regulation
Frontiers in Cellular Neuroscience, 2023 The cochlea is the sensory organ in the periphery, and hair cells are its main sensory cells. The development and survival of hair cells are highly controlled processes.
Ying Xiao, Dan Li
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Notch signaling limits supporting cell plasticity in the hair cell-damaged early postnatal murine cochlea. [PDF]
PLoS ONE, 2013 In mammals, auditory hair cells are generated only during embryonic development and loss or damage to hair cells is permanent. However, in non-mammalian vertebrate species, such as birds, neighboring glia-like supporting cells regenerate auditory hair ...
Soumya Korrapati +3 more
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Tmc Reliance Is Biased by the Hair Cell Subtype and Position Within the Ear
Frontiers in Cell and Developmental Biology, 2021 Hair cells are heterogenous, enabling varied roles in sensory systems. An emerging hypothesis is that the transmembrane channel-like (Tmc) proteins of the hair cell’s mechanotransduction apparatus vary within and between organs to permit encoding of ...
Shaoyuan Zhu +9 more
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eLife, 2023 A major cause of human deafness and vestibular dysfunction is permanent loss of the mechanosensory hair cells of the inner ear. In non-mammalian vertebrates such as zebrafish, regeneration of missing hair cells can occur throughout life.
Tuo Shi +7 more
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Hair Cell Generator Potentials [PDF]
The Journal of General Physiology, 1973 A technique is introduced using a piezoelectric device to stimulate hair cells of a molluscan statocyst while recording their responses intracellularly. Statocyst displacements produced with the technique are calibrated with stroboscopic photography. Properties of the hair cells' response to currents and mechanical stimulation are studied.
D L, Alkon, A, Bak
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Hair cell ribbon synapses [PDF]
Cell and Tissue Research, 2006 Hearing and balance rely on the faithful synaptic coding of mechanical input by the auditory and vestibular hair cells of the inner ear. Mechanical deflection of their stereocilia causes the opening of mechanosensitive channels, resulting in hair cell depolarization, which controls the release of glutamate at ribbon-type synapses.
Tobias, Moser +2 more
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