Results 21 to 30 of about 211,343 (216)

A Reversal in Hair Cell Orientation Organizes Both the Auditory and Vestibular Organs

Frontiers in Neuroscience, 2021
Sensory hair cells detect mechanical stimuli with their hair bundle, an asymmetrical brush of actin-based membrane protrusions, or stereocilia. At the single cell level, stereocilia are organized in rows of graded heights that confer the hair bundle with
Basile Tarchini, Basile Tarchini, Basile Tarchini   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A Case Series on Minimally Invasive Upper Arm Contouring: Efficacy of Combined Renuvion Helium Plasma and Icoone Multi‐Micro Alveolar Stimulation for Fat Reduction

Clinical Case Reports
The combination of Renuvion helium plasma and Icoone Multi Micro Alveolar Stimulation is an effective, minimally invasive approach for reducing upper arm fat and improving skin texture.
Mohammad Ali Nilforoushzadeh, Alireza Jafarzadeh, Tannaz Fakhim, Masoumeh Mohamadi, Fereshteh Salarvand, Farnaz Parvaresh, Niloufar Najar Nobari   +6 more
doaj   +1 more source

Activation of PI3K signaling prevents aminoglycoside-induced hair cell death in the murine cochlea

Biology Open, 2016
Loss of sensory hair cells of the inner ear due to aminoglycoside exposure is a major cause of hearing loss. Using an immortalized multipotent otic progenitor (iMOP) cell line, specific signaling pathways that promote otic cell survival were identified ...
Azadeh Jadali, Kelvin Y. Kwan
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A Novel Treatment Schedule Combining Injectable Platelet‐Rich Fibrin and Endolift Laser for Facial Rejuvenation: A Case Report

Clinical Case Reports
The combination of Endolift laser therapy and injectable platelet‐rich fibrin (i‐PRF) is an emerging strategy in aesthetic medicine, but the optimal scheduling of these modalities remains unexplored. This case report highlights a novel treatment schedule
Mohammad Ali Nilforoushzadeh, Pantea Bozorg Savoji, Tannaz Fakhim, Seyedeh Nasim Mirbahari   +3 more
doaj   +1 more source

Advances in stem cell-based therapy for hair loss [PDF]

CellR4, 2020
Hair loss is a quite common condition observed in both men and women. Pattern hair loss also known as androgenetic alopecia is the most common form of hair loss that is thought to affect up to 80% of Caucasian men and up to 40% of Caucasian women by age ...
A. Egger, M. Tomic-Canic, A. Tosti
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Regenerative Scalp Preparation With Stromal Vascular Fraction and Platelet‐Rich Fibrin Prior to Hair Transplantation in Lichen Planus: A Case Report

Clinical Case Reports
Lichen planus (LP) is a chronic inflammatory scalp disorder that can lead to cicatricial alopecia, making it challenging for hair transplantation. This case report describes a 26‐year‐old female with LP who underwent scalp preparation using SVF and PRF ...
Pantea Bozorg Savoji, Seyedeh Nasim Mirbahari, Shohreh Rafiee, Tannaz Fakhim, Mohammad Ali Nilforoushzadeh   +4 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source