Results 21 to 30 of about 5,277,672 (304)

GFI1 regulates hair cell differentiation by acting as an off-DNA transcriptional co-activator of ATOH1, and a DNA-binding repressor

Scientific Reports, 2022
GFI1 is a zinc finger transcription factor that is necessary for the differentiation and survival of hair cells in the cochlea. Deletion of Gfi1 in mice significantly reduces the expression of hundreds of hair cell genes: this is a surprising result, as ...
Hsin-I Jen, Sunita Singh, Litao Tao, Helen R. Maunsell, Neil Segil, Andrew K. Groves   +5 more
doaj   +1 more source

Characterizing human vestibular sensory epithelia for experimental studies: new hair bundles on old tissue and implications for therapeutic interventions in ageing. [PDF]

, 2015
Balance disequilibrium is a significant contributor to falls in the elderly. The most common cause of balance dysfunction is loss of sensory cells from the vestibular sensory epithelia of the inner ear.
Daniel J. Jagger, Axon, Patrick, Moffatt, D, Moffatt, David, Jagger, DJ, Tysome, James, Monksfield, Peter, Taylor, Ruth R., Jagger, Daniel J., Peter Monksfield, Donnelly, N, Lloyd, SK, Coulson, Chris, Irving, R, Coulson, C, Freeman, SR, Saeed, Shakeel R., Richard Irving, Simon K. Lloyd, Lloyd, Simon K., Forge, Andrew, Neil Donnelly, Freeman, Simon R., Shakeel R. Saeed, Taylor, RR, David Moffatt, Forge, A, Irving, Richard, Saeed, SR, Axon, P, Ruth R. Taylor, Monksfield, P, Simon R. Freeman, Donnelly, Neil, Chris Coulson, Tysome, J, Andrew Forge, Patrick Axon, James Tysome   +38 more
core   +1 more source

Transcriptomic Profiling of Zebrafish Hair Cells Using RiboTag

Frontiers in Cell and Developmental Biology, 2018
The zebrafish inner ear organs and lateral line neuromasts are comprised of a variety of cell types, including mechanosensitive hair cells. Zebrafish hair cells are evolutionarily homologous to mammalian hair cells, and have been particularly useful for ...
Maggie S. Matern, Alisha Beirl, Yoko Ogawa, Yang Song, Nikhil Paladugu, Katie S. Kindt, Ronna Hertzano, Ronna Hertzano, Ronna Hertzano   +8 more
doaj   +1 more source

Survival of auditory hair cells [PDF]

Cell and Tissue Research, 2015
The inability of mammals to regenerate auditory hair cells creates a pressing need to understand the means of enhancing hair cell survival following insult or injury. Hair cells are easily damaged by noise exposure, by ototoxic medications and as a consequence of aging processes, all of which lead to progressive and permanent hearing impairment as hair
Michelle L, Seymour, Fred A, Pereira
openaire   +2 more sources

Numb is not a critical regulator of Notch-mediated cell fate decisions in the developing chick inner ear. [PDF]

, 2015
The Notch signaling pathway controls differentiation of hair cells and supporting cells in the vertebrate inner ear. Here, we have investigated whether Numb, a known regulator of Notch activity in Drosophila, is involved in this process in the embryonic ...
Mark eEddison, Weber, SJ, Ariza-McNaughton, L, Julian eLewis, Nicolas eDaudet, Lewis, J, Sara Johanna Weber, Eddison, M, Daudet, N, Linda eAriza-McNaughton   +9 more
core   +1 more source

Transcription Factor Reprogramming in the Inner Ear: Turning on Cell Fate Switches to Regenerate Sensory Hair Cells

Frontiers in Cellular Neuroscience, 2021
Non-mammalian vertebrates can restore their auditory and vestibular hair cells naturally by triggering the regeneration of adjacent supporting cells. The transcription factor ATOH1 is a key regulator of hair cell development and regeneration in the inner
Amrita A. Iyer, Amrita A. Iyer, Andrew K. Groves, Andrew K. Groves, Andrew K. Groves   +4 more
doaj   +1 more source

The organization of tip links and stereocilia on hair cells of bird and lizard basilar papillae [PDF]

, 1989
Auditory papillae from three species of bird (pigeon, starling, and chick), and two species of European lizard (Podarcis murolis and Podarcis sic&) were examined by scanning electron microscopy.
Pickles, J. O., Gleich, O., Brix, J., Gleich, Otto, Comis, S. D., Osborne, M. P., Köppl, C., Manley, G. A.   +7 more
core   +1 more source

Stepwise fate conversion of supporting cells to sensory hair cells in the chick auditory epithelium

iScience, 2023
Summary: In contrast to mammals, the avian cochlea, specifically the basilar papilla, can regenerate sensory hair cells, which involves fate conversion of supporting cells to hair cells. To determine the mechanisms for converting supporting cells to hair
Mami Matsunaga, Ryosuke Yamamoto, Tomoko Kita, Hiroe Ohnishi, Norio Yamamoto, Takayuki Okano, Koichi Omori, Takayuki Nakagawa   +7 more
doaj   +1 more source

Prolactin delays hair regrowth in mice [PDF]

, 2006
Mammalian hair growth is cyclic, with hair-producing follicles alternating between active (anagen) and quiescent (telogen) phases. The timing of hair cycles is advanced in prolactin receptor (PRLR) knockout mice, suggesting that prolactin has a role in ...
Ashby, M.G., Nixon, A.J., Pearson, A.J., Ormandy, C.J., Blazek, K., Wilkins, Richard J., Craven, A.J.   +6 more
core   +1 more source

Activated notch causes deafness by promoting a supporting cell phenotype in developing auditory hair cells. [PDF]

PLoS ONE, 2014
To determine whether activated Notch can promote a supporting cell fate during sensory cell differentiation in the inner ear.An activated form of the Notch1 receptor (NICD) was expressed in early differentiating hair cells using a Gfi1-Cre mouse allele ...
Grace Savoy-Burke, Felicia A Gilels, Wei Pan, Diana Pratt, Jianwen Que, Lin Gan, Patricia M White, Amy E Kiernan   +7 more
doaj   +1 more source