Results 1 to 10 of about 19,052 (152)
Aminoglycosides-Related Ototoxicity: Mechanisms, Risk Factors, and Prevention in Pediatric Patients [PDF]
Pharmaceuticals, 2023 Aminoglycosides are broad-spectrum antibiotics largely used in children, but they have potential toxic side effects, including ototoxicity. Ototoxicity from aminoglycosides is permanent and is a consequence of its action on the inner ear cells via ...
Stefano Mastrangelo +2 more
exaly +5 more sources
Frontiers in Cellular Neuroscience, 2023 Mitochondrial dysfunction is associated with ototoxicity, which is caused by external factors. Mitophagy plays a key role in maintaining mitochondrial homeostasis and function and is regulated by a series of key mitophagy regulatory proteins and ...
Junbo Zhou, Hezhou Han, Dongliang Liu
exaly +3 more sources
The Pharmacogenomics of Cisplatin-Induced Ototoxicity [PDF]
LifeCisplatin is a first line treatment for a wide range of cancers; one commonly observed adverse drug reaction (ADR) of cisplatin is ototoxicity. Onset of ototoxicity from cisplatin is inconsistent and no single risk factor can reliably predict whether a ...
David Harman +4 more
doaj +2 more sources
TRPV4 mediates aminoglycoside trafficking and ototoxicity without compromising antimicrobial efficacy [PDF]
Cell Death DiscoveryAminoglycoside (AG) antibiotics remain essential for treating life-threatening infections; however, their clinical use is limited by irreversible ototoxicity.
Lingshuai Kong +5 more
doaj +2 more sources
Age‐Dependent Patterns of Cisplatin‐Induced Ototoxicity in Head and Neck Cancer: A Longitudinal Audiologic Analysis [PDF]
Cancer MedicineBackground Cisplatin (CDDP) is a key chemotherapeutic agent used to treat head and neck cancer. Improved survival rates have increased concerns about CDDP‐induced ototoxicity, as this toxicity significantly impacts survivors' quality of life.
C. Suzuki +8 more
doaj +2 more sources
Ototoxicity monitoring in South African cancer facilities: A national survey
South African Journal of Communication Disorders, 2022 Background: National information regarding ototoxicity monitoring practices are limited for patients undergoing chemotherapy in South Africa. Objectives: To determine (1) the national status of ototoxicity monitoring implemented in private and public ...
Katerina Ehlert +2 more
doaj +1 more source
Journal of Pharmacy and Bioallied Sciences, 2021 Aim: The study explored the South African healthcare context for ototoxicity assessment and management from the audiologists’ perspectives. Materials and Methods: This was done through a survey research methodology that adopted a cross-sectional research
Katijah Khoza-Shangase, Nothando Masondo
doaj +1 more source
Auditory fatigue among call dispatchers working with headsets
International Journal of Occupational Medicine and Environmental Health, 2018 Objectives To determine whether call center dispatchers wearing headsets are subject to auditory fatigue at the end of a work shift. Material and Methods Data was gathered at times when call centers were busiest. All call operators wore a headset for up
Thomas Venet +8 more
doaj +1 more source
Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2021 Background: Hearing impairment due to ototoxicity is one common cause adding to global burden of disability. Amikacin and kanamycin are two common Aminoglycosides used to treat multidrug resistant tuberculosis which results in ototoxicity.
Pelden Wangchuk +3 more
doaj +1 more source
BMC Pharmacology and Toxicology, 2023 Purpose Cisplatin is a widely used and effective chemotherapeutic agent for most solid malignant tumors. However, cisplatin-induced ototoxicity is a common adverse effect that limits the therapeutic efficacy of tumors in the clinic. To date, the specific
Haiyan Wang +11 more
doaj +1 more source