Results 1 to 10 of about 25,486 (236)

Mechanistic insights into cisplatin-induced ototoxicity: the central role of transient receptor potential channels [PDF]

Frontiers in Molecular Biosciences
This review systematically elucidates the molecular mechanisms underlying cisplatin-induced ototoxicity, with a particular focus on the pivotal role played by TRP channels.
Man Yu, Man Yu, Juanjuan Li, Xianhai Zeng, Xianhai Zeng   +4 more
doaj   +2 more sources

Mitophagy in ototoxicity

Frontiers in Cellular Neuroscience, 2023
Mitochondrial dysfunction is associated with ototoxicity, which is caused by external factors. Mitophagy plays a key role in maintaining mitochondrial homeostasis and function and is regulated by a series of key mitophagy regulatory proteins and ...
Hezhou Han, Sainan Hu, Yue Hu, Dongliang Liu, Junbo Zhou, Xiaofang Liu, Xiulan Ma, Yaodong Dong   +7 more
doaj   +1 more source

Aminoglycosides-Related Ototoxicity: Mechanisms, Risk Factors, and Prevention in Pediatric Patients

Pharmaceuticals, 2023
Aminoglycosides are broad-spectrum antibiotics largely used in children, but they have potential toxic side effects, including ototoxicity. Ototoxicity from aminoglycosides is permanent and is a consequence of its action on the inner ear cells via ...
Serena Rivetti, Alberto Romano, Stefano Mastrangelo, Giorgio Attinà, Palma Maurizi, Antonio Ruggiero   +5 more
doaj   +1 more source

Ototoxicity monitoring in South African cancer facilities: A national survey

South African Journal of Communication Disorders, 2022
Background: National information regarding ototoxicity monitoring practices are limited for patients undergoing chemotherapy in South Africa. Objectives: To determine (1) the national status of ototoxicity monitoring implemented in private and public ...
Katerina Ehlert, Barbara Heinze, De Wet Swanepoel   +2 more
doaj   +1 more source

In pursuit of preventive audiology in South Africa: Scoping the context for ototoxicity assessment and management

Journal of Pharmacy and Bioallied Sciences, 2021
Aim: The study explored the South African healthcare context for ototoxicity assessment and management from the audiologists’ perspectives. Materials and Methods: This was done through a survey research methodology that adopted a cross-sectional research
Katijah Khoza-Shangase, Nothando Masondo
doaj   +1 more source

Audiological monitoring of patients undergoing multidrug resistant tuberculosis treatment at Jigme Dorji Wangchuk National Referral Hospital and Gidakom Hospital, Bhutan

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2021
Background: Hearing impairment due to ototoxicity is one common cause adding to global burden of disability. Amikacin and kanamycin are two common Aminoglycosides used to treat multidrug resistant tuberculosis which results in ototoxicity.
Pelden Wangchuk, Tika Ram Adhikari, Gaki Nima, Phuntsho Dendup   +3 more
doaj   +1 more source

A Study on Prevalence and Determinants of Ototoxicity During Treatment of Childhood Cancer (SOUND): Protocol for a Prospective Study

JMIR Research Protocols, 2022
BackgroundSome children with central nervous system (CNS) and solid tumors are at risk to develop ototoxicity during treatment.
Franciscus A Diepstraten, Annelot JM Meijer, Martine van Grotel, Sabine LA Plasschaert, Alexander E Hoetink, Marta Fiocco, Geert O Janssens, Robert J Stokroos, Marry M van den Heuvel-Eibrink   +8 more
doaj   +1 more source

miR-34a/DRP-1-mediated mitophagy participated in cisplatin-induced ototoxicity via increasing oxidative stress

BMC Pharmacology and Toxicology, 2023
Purpose Cisplatin is a widely used and effective chemotherapeutic agent for most solid malignant tumors. However, cisplatin-induced ototoxicity is a common adverse effect that limits the therapeutic efficacy of tumors in the clinic. To date, the specific
Haiyan Wang, Hanqing Lin, Weibiao Kang, Lingfei Huang, Sisi Gong, Tao Zhang, Xiaotong Huang, Feinan He, Yongyi Ye, Yiyang Tang, Haiying Jia, Haidi Yang   +11 more
doaj   +1 more source

Auditory fatigue among call dispatchers working with headsets

International Journal of Occupational Medicine and Environmental Health, 2018
Objectives To determine whether call center dispatchers wearing headsets are subject to auditory fatigue at the end of a work shift. Material and Methods Data was gathered at times when call centers were busiest. All call operators wore a headset for up
Thomas Venet, Ayoub Bey, Pierre Campo, Joël Ducourneau, Quentin Mifsud, Charles Hoffmann, Aurélie Thomas, Marc Mouzé-Amady, Cécile Parietti-Winkler   +8 more
doaj   +1 more source

Early and Long-Term Ototoxicity Noted in Children Due to Platinum Compounds: Prevalence and Risk Factors

Biomedicines, 2023
Background: Platinum compounds are a group of fundamental chemotherapeutics used in the treatment of solid tumors, but they are burdened by side effects, such as ototoxicity. The objective of this study was to evaluate the incidence of ototoxicity caused
Alberto Romano, Serena Rivetti, Francesca Brigato, Stefano Mastrangelo, Giorgio Attinà, Palma Maurizi, Jacopo Galli, Anna Rita Fetoni, Antonio Ruggiero   +8 more
doaj   +1 more source