Results 11 to 20 of about 19,052 (152)

Early and Long-Term Ototoxicity Noted in Children Due to Platinum Compounds: Prevalence and Risk Factors

Biomedicines, 2023
Background: Platinum compounds are a group of fundamental chemotherapeutics used in the treatment of solid tumors, but they are burdened by side effects, such as ototoxicity. The objective of this study was to evaluate the incidence of ototoxicity caused
Alberto Romano, Serena Rivetti, Francesca Brigato, Stefano Mastrangelo, Giorgio Attinà, Palma Maurizi, Jacopo Galli, Anna Rita Fetoni, Antonio Ruggiero   +8 more
doaj   +2 more sources

Re-telling the story of aminoglycoside ototoxicity: tales from sub-Saharan Africa [PDF]

Frontiers in Neurology
BackgroundAminoglycosides, such as Streptomycin, are cheap, potent antibiotics widely used Sub-Saharan Africa. However, aminoglycosides are the commonest cause of ototoxicity.
Adebolajo A. Adeyemo, Adebolajo A. Adeyemo, Babatunde Adedokun, Josephine Adeolu, Joshua O. Akinyemi, Olayemi O. Omotade, Odunayo M. Oluwatosin   +6 more
doaj   +2 more sources

Which Environmental Pollutants Are Toxic to Our Ears?—Evidence of the Ototoxicity of Common Substances

Toxics
Ototoxicity refers to the adverse effects of substances on auditory or vestibular functions. This study examines the evidence of ototoxicity’s association with exposure to common environmental pollutants, as documented in toxicological profiles by the ...
Gregory M. Zarus, Patricia Ruiz, Rae Benedict, Stephan Brenner, Krystin Carlson, Layna Jeong, Thais C. Morata   +6 more
doaj   +2 more sources

Relationship Between Serum Ferritin Level and Amikacin Ototoxicity [PDF]

Oman Medical Journal, 2012
Objectives: Aminoglycosides are highly effective against bacteria but have serious side-effects including ototoxicity and nephrotoxicity. One of the theories in aminoglycosides ototoxicity is that Iron-aminoglycoside complex causes ototoxicity by ...
Mohammad Shayaninasab, Mohammadreza Fatololoomi, Fatollah Behnood, Azam Alizamir   +3 more
doaj   +1 more source

Ototoxicity of Immunosuppressant Drugs: A Systematic Review [PDF]

, 2022
Background : Nowadays, immunosuppressant drugs are widely used to prevent rejection in organ transplantation and to treat autoimmune diseases. Ototoxicity related to immunosuppressant drugs has been anecdotally reported but scarcely investigated. The aim
Parrino, Daniela, Daniela Parrino, Andrea Lovato, Gino Marioni, Leonardo Franz, Marioni, Gino, Franz, Leonardo, Andrea Frosolini, Frosolini, Andrea, Lovato, Andrea, de Filippis, Cosimo, Cosimo de Filippis   +11 more
core   +2 more sources

Prevalence and Risk Factors for Ototoxicity After Cisplatin-based Chemotherapy [PDF]

, 2023
Purpose Ototoxicity is a prominent side effect of cisplatin-based chemotherapy. There are few reports, however, estimating its prevalence in well-defined cohorts and associated risk factors.
Fung, Chunkit, Travis, Lois B., Rooker, Jennessa, Dolan, M. Eileen, Dinh, Paul C., Sesso, Howard D., Sanchez, Victoria A., Althouse, Sandra K., Frisina, Robert D., Monahan, Patrick O., Einhorn, Lawrence H.   +10 more
core   +1 more source

Cellular glutathione content in the organ of Corti and its role during ototoxicity. [PDF]

, 2015
Glutathione (GSH) is the major scavenger of reactive oxygen species (ROS) inside cells. We used live confocal imaging in order to clarify the role of GSH in the biology of the organ of Corti, the sensory epithelium of the cochlea, before, during and ...
Paromita Majumder, Majumder, P, Duchen, MR, Jonathan E. Gale, Michael R. Duchen, Gale, JE   +5 more
core   +1 more source

A Study on Prevalence and Determinants of Ototoxicity During Treatment of Childhood Cancer (SOUND): Protocol for a Prospective Study

JMIR Research Protocols, 2022
BackgroundSome children with central nervous system (CNS) and solid tumors are at risk to develop ototoxicity during treatment.
Franciscus A Diepstraten, Annelot JM Meijer, Martine van Grotel, Sabine LA Plasschaert, Alexander E Hoetink, Marta Fiocco, Geert O Janssens, Robert J Stokroos, Marry M van den Heuvel-Eibrink   +8 more
doaj   +1 more source

Detecting Novel Ototoxins and Potentiation of Ototoxicity by Disease Settings

Frontiers in Neurology, 2021
Over 100 drugs and chemicals are associated with permanent hearing loss, tinnitus, and vestibular deficits, collectively known as ototoxicity. The ototoxic potential of drugs is rarely assessed in pre-clinical drug development or during clinical trials ...
Allison B. Coffin, Robert Boney, Jordan Hill, Cong Tian, Peter S. Steyger, Peter S. Steyger   +5 more
doaj   +1 more source

Audiological testing for ototoxicity monitoring in adults with tuberculosis in state hospitals in Gauteng, South Africa

Southern African Journal of Infectious Diseases, 2016
Background: Ototoxicity monitoring during treatment of medical conditions, where the medications used are known to be toxic to the ear, is an important scope of practice of the audiologist; and, is an important clinical service aimed at enhancing ...
Katijah Khoza-Shangase, Megan Stirk
doaj   +1 more source