Results 11 to 20 of about 13,799 (205)
Kidney International, 2007 This paper reviews intriguing recent findings on the mechanisms of drug induced hearing loss caused by two major classes of therapeutic agents: the aminoglycoside antibiotics and cisplatin. Both drug categories are nephrotoxic as well as ototoxic. Aminoglycosides and cisplatin target the outer hair cells in the basal turn of the cochlea to cause high ...
Rybak, L.P., Ramkumar, V.
openaire +2 more sources
Antimicrobial Agents and Chemotherapy, 1976 Amikacin was used in 77 treatment courses at a dosage of ≥7.5 mg/kg every 8 h, and patients were monitored for ototoxicity by following serial audiograms, serum creatinine, and amikacin blood levels. Patients were leukopenic (58), were infected by gentamicin-resistant organisms (11), or had cystic fibrosis (8).
R E, Black +4 more
openaire +2 more sources
Detecting Novel Ototoxins and Potentiation of Ototoxicity by Disease Settings
Frontiers in Neurology, 2021 Over 100 drugs and chemicals are associated with permanent hearing loss, tinnitus, and vestibular deficits, collectively known as ototoxicity. The ototoxic potential of drugs is rarely assessed in pre-clinical drug development or during clinical trials ...
Allison B. Coffin +5 more
doaj +1 more source
Southern African Journal of Infectious Diseases, 2016 Background: Ototoxicity monitoring during treatment of medical conditions, where the medications used are known to be toxic to the ear, is an important scope of practice of the audiologist; and, is an important clinical service aimed at enhancing ...
Katijah Khoza-Shangase, Megan Stirk
doaj +1 more source
Tetrandrine Prevents Neomycin-Induced Ototoxicity by Promoting Steroid Biosynthesis
Frontiers in Bioengineering and Biotechnology, 2022 Aminoglycoside antibiotics are widely used for the treatment of serious acute infections, life-threatening sepsis, and tuberculosis, but all aminoglycosides cause side effects, especially irreversible ototoxicity.
Qilei Zhang +14 more
doaj +1 more source
South African Journal of Communication Disorders, 2022 Background: South Africa has a high burden of drug-resistant tuberculosis (DRTB) and until recently, ototoxic aminoglycosides were predominant in treatment regimens. Community-based ototoxicity monitoring programmes (OMPs) have been implemented for early
Lucia J. Stevenson +3 more
doaj +1 more source
Re-telling the story of aminoglycoside ototoxicity: tales from sub-Saharan Africa
Frontiers in NeurologyBackgroundAminoglycosides, such as Streptomycin, are cheap, potent antibiotics widely used Sub-Saharan Africa. However, aminoglycosides are the commonest cause of ototoxicity.
Adebolajo A. Adeyemo +6 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Hearing loss (ototoxicity) is a major adverse effect of cisplatin and carboplatin chemotherapy. The aim of this study is to identify novel genetic variants that play a role in platinum-induced ototoxicity.
Evelien G. E. Hurkmans +35 more
doaj +1 more source
After surviving cancer, what about late life effects of the cure?
EMBO Molecular Medicine, 2016 The widely used chemotherapeutic cisplatin causes ototoxicity as late‐term side effect. In this issue, Benkafadar et al (2017) decipher the mechanism of cisplatin‐induced ototoxicity and provide evidence that transient inhibition of p53 ameliorates ...
Julie Nonnekens, Jan HJ Hoeijmakers
doaj +1 more source
Predictive model for aminoglycoside induced ototoxicity
Frontiers in NeurologyBackgroundIrreversible hearing loss is a well-known adverse effect of aminoglycosides, however, inability to accurately predict ototoxicity is a major limitation in clinical care.
Adebolajo A. Adeyemo +5 more
doaj +1 more source