Results 11 to 20 of about 17,163 (245)

Perspectives and practices of ototoxicity monitoring

South African Journal of Communication Disorders, 2020
Background: Treatment of cancer with cisplatin can result in hearing loss. Given the increasing burden of cancer in Africa, appropriate and timely identification, intervention and management of hearing loss in affected patients is of paramount importance.
Jessica Paken, Cyril D. Govender, Mershen Pillay, Vikash Sewram   +3 more
doaj   +3 more sources

DRUG-INDUCED OTOTOXICITY. AMINOGLYCOSIDE OTOTOXICITY

Grail of Science, 2022
In modern clinical practice, there are often cases of cochleovestibular disorders induced by the use of drugs. The term "drug-induced ototoxicity" is directly related to the introduction of streptomycin in medical practice and means the ability of drugs or chemicals to cause functional disorders and degeneration of internal ear structures: sensory ...
Artemii Litvinenko, Inna Chebernina
openaire   +2 more sources

The Discovery of Salicylate Ototoxicity

Audiology and Neurotology, 2007
Although the name of the discoverer of salicylate ototoxicity is still debated, most authors have quoted Müller and his 1877 report. To the best of our knowledge, the true discoverer of the transient ototoxicity of salicylate was the Italian chemist Cesare Bertagnini who reported this evidence in 1855 in the journal <i>Il Nuovo Cimento</i>.
Marchese Ragona R, MARIONI, GINO, Marson P, MARTINI, ALESSANDRO, STAFFIERI, ALBERTO   +4 more
openaire   +5 more sources

Relationship Between Serum Ferritin Level and Amikacin Ototoxicity [PDF]

Oman Medical Journal, 2012
Objectives: Aminoglycosides are highly effective against bacteria but have serious side-effects including ototoxicity and nephrotoxicity. One of the theories in aminoglycosides ototoxicity is that Iron-aminoglycoside complex causes ototoxicity by ...
Mohammad Shayaninasab, Mohammadreza Fatololoomi, Fatollah Behnood, Azam Alizamir   +3 more
doaj   +1 more source

Ototoxicity of Immunosuppressant Drugs: A Systematic Review [PDF]

, 2022
Background : Nowadays, immunosuppressant drugs are widely used to prevent rejection in organ transplantation and to treat autoimmune diseases. Ototoxicity related to immunosuppressant drugs has been anecdotally reported but scarcely investigated. The aim
Parrino, Daniela, Daniela Parrino, Andrea Lovato, Gino Marioni, Leonardo Franz, Marioni, Gino, Franz, Leonardo, Andrea Frosolini, Frosolini, Andrea, Lovato, Andrea, de Filippis, Cosimo, Cosimo de Filippis   +11 more
core   +2 more sources

Circadian-Related Serotonin/Melatonin Level Modulates Cisplatin Ototoxicity Susceptibility Depended on NOS3-NO Pathway. [PDF]

J Pineal Res
ABSTRACT Hearing impairment is attributed to factors such as age, genetic predisposition, and environmental influences, among which environmental factors are considered modifiable. Among various environmental factors, the role of poor lifestyle habits is particularly critical, yet the specific mechanisms by which they contribute to hearing damage ...
Qiu S, Cai S, Xie R, Liu C, He Y.
europepmc   +2 more sources

Ototoxicity [PDF]

Kidney International, 2007
This paper reviews intriguing recent findings on the mechanisms of drug induced hearing loss caused by two major classes of therapeutic agents: the aminoglycoside antibiotics and cisplatin. Both drug categories are nephrotoxic as well as ototoxic. Aminoglycosides and cisplatin target the outer hair cells in the basal turn of the cochlea to cause high ...
Rybak, L.P., Ramkumar, V.
openaire   +2 more sources

Detecting Novel Ototoxins and Potentiation of Ototoxicity by Disease Settings

Frontiers in Neurology, 2021
Over 100 drugs and chemicals are associated with permanent hearing loss, tinnitus, and vestibular deficits, collectively known as ototoxicity. The ototoxic potential of drugs is rarely assessed in pre-clinical drug development or during clinical trials ...
Allison B. Coffin, Robert Boney, Jordan Hill, Cong Tian, Peter S. Steyger, Peter S. Steyger   +5 more
doaj   +1 more source

A longitudinal community-based ototoxicity monitoring programme and treatment effects for drug-resistant tuberculosis treatment, Western Cape

South African Journal of Communication Disorders, 2022
Background: South Africa has a high burden of drug-resistant tuberculosis (DRTB) and until recently, ototoxic aminoglycosides were predominant in treatment regimens. Community-based ototoxicity monitoring programmes (OMPs) have been implemented for early
Lucia J. Stevenson, Leigh Biagio-de Jager, Marien A. Graham, De Wet Swanepoel   +3 more
doaj   +1 more source

Audiological testing for ototoxicity monitoring in adults with tuberculosis in state hospitals in Gauteng, South Africa

Southern African Journal of Infectious Diseases, 2016
Background: Ototoxicity monitoring during treatment of medical conditions, where the medications used are known to be toxic to the ear, is an important scope of practice of the audiologist; and, is an important clinical service aimed at enhancing ...
Katijah Khoza-Shangase, Megan Stirk
doaj   +1 more source