Results 21 to 30 of about 19,052 (152)

Prevention of treatment-induced ototoxicity: An update for clinicians [PDF]

, 2019
Ototoxicity is a common side-effect during treatment of a a number of life-threatening health conditions. Often, when treating such conditions, the focus tends to be on saving the patient’s life rather than preserving their hearing or vestibular function.
Heinze, Birgit, Ramma, Lebogang, Schellack, N, Schellack, Natalie, Heinze, B, Ramma, L   +5 more
core   +1 more source

Tetrandrine Prevents Neomycin-Induced Ototoxicity by Promoting Steroid Biosynthesis

Frontiers in Bioengineering and Biotechnology, 2022
Aminoglycoside antibiotics are widely used for the treatment of serious acute infections, life-threatening sepsis, and tuberculosis, but all aminoglycosides cause side effects, especially irreversible ototoxicity.
Qilei Zhang, Yunhao Wu, Yan Yu, Yuguang Niu, Qiaojun Fang, Xin Chen, Jieyu Qi, Chen Zhang, Geping Wu, Kaiming Su, Renjie Chai, Renjie Chai, Renjie Chai, Renjie Chai, Renjie Chai   +14 more
doaj   +1 more source

Effect of Transtympanic Injection of Melatonin on Cisplatin-Induced Ototoxicity

, 2015
OBJECTIVE: Cisplatin is a chemotherapeutic agent that is widely used in cancer treatment. Numerous side effects have been detected, one of which is ototoxicity.
Demir, Mehmet Gökhan, Sedat Aydin, Kayhan Basak, BASAK, Kayhan, Aydin, Sedat, Niyazi Altintoprak, Ebru Kosemihal, Kosemihal, Ebru, ALTINTOPRAK, Niyazi, Mehmet Gokhan Demir   +9 more
core   +1 more source

A longitudinal community-based ototoxicity monitoring programme and treatment effects for drug-resistant tuberculosis treatment, Western Cape

South African Journal of Communication Disorders, 2022
Background: South Africa has a high burden of drug-resistant tuberculosis (DRTB) and until recently, ototoxic aminoglycosides were predominant in treatment regimens. Community-based ototoxicity monitoring programmes (OMPs) have been implemented for early
Lucia J. Stevenson, Leigh Biagio-de Jager, Marien A. Graham, De Wet Swanepoel   +3 more
doaj   +1 more source

After surviving cancer, what about late life effects of the cure?

EMBO Molecular Medicine, 2016
The widely used chemotherapeutic cisplatin causes ototoxicity as late‐term side effect. In this issue, Benkafadar et al (2017) decipher the mechanism of cisplatin‐induced ototoxicity and provide evidence that transient inhibition of p53 ameliorates ...
Julie Nonnekens, Jan HJ Hoeijmakers
doaj   +1 more source

High incidence of cisplatin-induced ototoxicity in paediatric patients in the Western Cape, South Africa

South African Journal of Oncology, 2018
Background: Fourteen million new cancer cases are reported annually, and up to 10% of those involve children below 15 years. Cisplatin, a commonly used anti-cancer drug for its high success rate, is associated with ototoxicity.
Mukovhe Phanguphangu, Lebogang Ramma
doaj   +1 more source

Predictive model for aminoglycoside induced ototoxicity

Frontiers in Neurology
BackgroundIrreversible hearing loss is a well-known adverse effect of aminoglycosides, however, inability to accurately predict ototoxicity is a major limitation in clinical care.
Adebolajo A. Adeyemo, Adebolajo A. Adeyemo, Josephine Adeolu, Joshua O. Akinyemi, Olayemi O. Omotade, Odunayo M. Oluwatosin   +5 more
doaj   +1 more source

Genome-wide analyses of platinum-induced ototoxicity in childhood cancer patients: Results of GO-CAT and United Kingdom MAGIC consortia

Frontiers in Pharmacology, 2023
Hearing loss (ototoxicity) is a major adverse effect of cisplatin and carboplatin chemotherapy. The aim of this study is to identify novel genetic variants that play a role in platinum-induced ototoxicity.
Evelien G. E. Hurkmans, Marije J. Klumpers, Cinzia Dello Russo, Cinzia Dello Russo, Ward De Witte, Henk-Jan Guchelaar, Hans Gelderblom, Anne-Marie Cleton-Jansen, Sita H. Vermeulen, Suzanne Kaal, Winette T. A. van der Graaf, Winette T. A. van der Graaf, Uta Flucke, Corrie E. M. Gidding, Hendrik W. B. Schreuder, Eveline S. J. M. de Bont, Huib N. Caron, Giovanna Gattuso, Elisabetta Schiavello, Monica Terenziani, Maura Massimino, Geoff McCowage, Sumanth Nagabushan, Sumanth Nagabushan, Anuja Limaye, Victoria Rose, Daniel Catchpoole, Andrea L. Jorgensen, Christopher Barton, Lucy Delaney, Daniel B. Hawcutt, Daniel B. Hawcutt, Munir Pirmohamed, Barry Pizer, Marieke J. H. Coenen, D. Maroeska W. M. te Loo   +35 more
doaj   +1 more source

Bromocriptine-associated ototoxicity [PDF]

, 1984
Three patients treated with bromocriptine for chronic hepatic encephalopathy showed audiometric evidence of bilateral sensori-neural hearing-loss. Audiometrically, the hearing improved in all three patients when the bromocriptine dosage was reduced, thus
Morgan, MY, Ballantyne, J, Lanthier, PL
core  

Ototoxicity Induced by Cinnabar (a Naturally Occurring Hgs) in Mice through Oxidative Stress and down-Regulated Na+/K+-Atpase Activities

, 2009
Cinnabar, a naturally occurring mercuric sulfide (HgS), has long been used in Chinese mineral medicine for more than 2000 years; currently it is still used as a sedative for infants in Asian countries.
黃俊發;許權振;劉興華;蕭水銀, HUANG, CHUN-FA;HSU, CHUAN-JEN;LIU, SHING-HWA;LIN-SHIAU, SHOEI-YN   +1 more
core   +1 more source