Results 21 to 30 of about 17,163 (245)
Tetrandrine Prevents Neomycin-Induced Ototoxicity by Promoting Steroid Biosynthesis
Frontiers in Bioengineering and Biotechnology, 2022 Aminoglycoside antibiotics are widely used for the treatment of serious acute infections, life-threatening sepsis, and tuberculosis, but all aminoglycosides cause side effects, especially irreversible ototoxicity.
Qilei Zhang +14 more
doaj +1 more source
Antimicrobial Agents and Chemotherapy, 1976 Amikacin was used in 77 treatment courses at a dosage of ≥7.5 mg/kg every 8 h, and patients were monitored for ototoxicity by following serial audiograms, serum creatinine, and amikacin blood levels. Patients were leukopenic (58), were infected by gentamicin-resistant organisms (11), or had cystic fibrosis (8).
R E, Black +4 more
openaire +2 more sources
Frontiers in Pharmacology, 2023 Hearing loss (ototoxicity) is a major adverse effect of cisplatin and carboplatin chemotherapy. The aim of this study is to identify novel genetic variants that play a role in platinum-induced ototoxicity.
Evelien G. E. Hurkmans +35 more
doaj +1 more source
Re-telling the story of aminoglycoside ototoxicity: tales from sub-Saharan Africa
Frontiers in NeurologyBackgroundAminoglycosides, such as Streptomycin, are cheap, potent antibiotics widely used Sub-Saharan Africa. However, aminoglycosides are the commonest cause of ototoxicity.
Adebolajo A. Adeyemo +6 more
doaj +1 more source
Audiology Research, 2023 Ototoxic drugs can result in hearing loss and tinnitus. Early detection of the ototoxic process can help minimize or prevent these consequences. The American Speech–Language–Hearing Association has provided guidelines for monitoring ototoxicity, whereas ...
Valeria Gambacorta +7 more
doaj +1 more source
South African Journal of Oncology, 2018 Background: Fourteen million new cancer cases are reported annually, and up to 10% of those involve children below 15 years. Cisplatin, a commonly used anti-cancer drug for its high success rate, is associated with ototoxicity.
Mukovhe Phanguphangu, Lebogang Ramma
doaj +1 more source
Insight into the current practice of ototoxicity monitoring during cisplatin therapy
Journal of Otolaryngology - Head and Neck Surgery, 2021 Background The aim of this study is to evaluate the current state of ototoxicity monitoring for patients receiving cisplatin chemotherapy in an academic medical center with particular attention to how closely monitoring adheres to national ototoxicity ...
N. M. Santucci +5 more
doaj +1 more source
After surviving cancer, what about late life effects of the cure?
EMBO Molecular Medicine, 2016 The widely used chemotherapeutic cisplatin causes ototoxicity as late‐term side effect. In this issue, Benkafadar et al (2017) decipher the mechanism of cisplatin‐induced ototoxicity and provide evidence that transient inhibition of p53 ameliorates ...
Julie Nonnekens, Jan HJ Hoeijmakers
doaj +1 more source
Cellular glutathione content in the organ of Corti and its role during ototoxicity.
, 2015 Glutathione (GSH) is the major scavenger of reactive oxygen species (ROS) inside cells. We used live confocal imaging in order to clarify the role of GSH in the biology of the organ of Corti, the sensory epithelium of the cochlea, before, during and ...
Paromita Majumder +5 more
core +1 more source
Predictive model for aminoglycoside induced ototoxicity
Frontiers in NeurologyBackgroundIrreversible hearing loss is a well-known adverse effect of aminoglycosides, however, inability to accurately predict ototoxicity is a major limitation in clinical care.
Adebolajo A. Adeyemo +5 more
doaj +1 more source