Results 21 to 30 of about 25,486 (236)

Myosin VIIA is required for aminoglycoside accumulation in cochlear hair cells. [PDF]

, 1997
Myosin VIIA is expressed by sensory hair cells and has a primary structure predicting a role in membrane trafficking and turnover, processes that may underlie the susceptibility of hair cells to aminoglycoside antibiotics. [3H]Gentamicin accumulation and
Brown, S D M, Fleming, J, Forge, A, Kros, C J, Richardson, G P, Steel, K P   +5 more
core   +2 more sources

Tetrandrine Prevents Neomycin-Induced Ototoxicity by Promoting Steroid Biosynthesis

Frontiers in Bioengineering and Biotechnology, 2022
Aminoglycoside antibiotics are widely used for the treatment of serious acute infections, life-threatening sepsis, and tuberculosis, but all aminoglycosides cause side effects, especially irreversible ototoxicity.
Qilei Zhang, Yunhao Wu, Yan Yu, Yuguang Niu, Qiaojun Fang, Xin Chen, Jieyu Qi, Chen Zhang, Geping Wu, Kaiming Su, Renjie Chai, Renjie Chai, Renjie Chai, Renjie Chai, Renjie Chai   +14 more
doaj   +1 more source

A longitudinal community-based ototoxicity monitoring programme and treatment effects for drug-resistant tuberculosis treatment, Western Cape

South African Journal of Communication Disorders, 2022
Background: South Africa has a high burden of drug-resistant tuberculosis (DRTB) and until recently, ototoxic aminoglycosides were predominant in treatment regimens. Community-based ototoxicity monitoring programmes (OMPs) have been implemented for early
Lucia J. Stevenson, Leigh Biagio-de Jager, Marien A. Graham, De Wet Swanepoel   +3 more
doaj   +1 more source

Bromocriptine-associated ototoxicity [PDF]

, 2007
Three patients treated with bromocriptine for chronic hepatic encephalopathy showed audiometric evidence of bilateral sensori-neural hearing-loss. Audiometrically, the hearing improved in all three patients when the bromocriptine dosage was reduced, thus
Ballantyne, J, Lanthier, PL, Morgan, MY
core   +1 more source

Audiological testing for ototoxicity monitoring in adults with tuberculosis in state hospitals in Gauteng, South Africa

Southern African Journal of Infectious Diseases, 2016
Background: Ototoxicity monitoring during treatment of medical conditions, where the medications used are known to be toxic to the ear, is an important scope of practice of the audiologist; and, is an important clinical service aimed at enhancing ...
Katijah Khoza-Shangase, Megan Stirk
doaj   +1 more source

Genome-wide analyses of platinum-induced ototoxicity in childhood cancer patients: Results of GO-CAT and United Kingdom MAGIC consortia

Frontiers in Pharmacology, 2023
Hearing loss (ototoxicity) is a major adverse effect of cisplatin and carboplatin chemotherapy. The aim of this study is to identify novel genetic variants that play a role in platinum-induced ototoxicity.
Evelien G. E. Hurkmans, Marije J. Klumpers, Cinzia Dello Russo, Cinzia Dello Russo, Ward De Witte, Henk-Jan Guchelaar, Hans Gelderblom, Anne-Marie Cleton-Jansen, Sita H. Vermeulen, Suzanne Kaal, Winette T. A. van der Graaf, Winette T. A. van der Graaf, Uta Flucke, Corrie E. M. Gidding, Hendrik W. B. Schreuder, Eveline S. J. M. de Bont, Huib N. Caron, Giovanna Gattuso, Elisabetta Schiavello, Monica Terenziani, Maura Massimino, Geoff McCowage, Sumanth Nagabushan, Sumanth Nagabushan, Anuja Limaye, Victoria Rose, Daniel Catchpoole, Andrea L. Jorgensen, Christopher Barton, Lucy Delaney, Daniel B. Hawcutt, Daniel B. Hawcutt, Munir Pirmohamed, Barry Pizer, Marieke J. H. Coenen, D. Maroeska W. M. te Loo   +35 more
doaj   +1 more source

Bucillamine prevents cisplatin-induced ototoxicity through induction of glutathione and antioxidant genes. [PDF]

, 2015
Bucillamine is used for the treatment of rheumatoid arthritis. This study investigated the protective effects of bucillamine against cisplatin-induced damage in auditory cells, the organ of Corti from postnatal rats (P2) and adult Balb/C mice.
Choe, Seong-Kyu, Ho Hur, Joon, Kim, Hyung-Jin, Kim, Se-Jin, Lee, Joon No, Lim, David J, Moon, Sung K, Oh, Gi-Su, Park, Channy, Park, Raekil, So, Hong-Seob, Yoo, Su-Jin   +11 more
core   +2 more sources

Prevention of cisplatin-induced hearing loss in children: Informing the design of future clinical trials. [PDF]

, 2018
Cisplatin is an essential chemotherapeutic agent in the treatment of many pediatric cancers. Unfortunately, cisplatin-induced hearing loss (CIHL) is a common, clinically significant side effect with life-long ramifications, particularly for young ...
Chang, Kay, Frazier, A, Freyer, David, Kelaghan, Joseph, Krailo, Mark, Minasian, Lori, OMara, Ann, Pollock, Bradley, Reaman, Gregory, Sung, Lillian   +9 more
core   +1 more source

High incidence of cisplatin-induced ototoxicity in paediatric patients in the Western Cape, South Africa

South African Journal of Oncology, 2018
Background: Fourteen million new cancer cases are reported annually, and up to 10% of those involve children below 15 years. Cisplatin, a commonly used anti-cancer drug for its high success rate, is associated with ototoxicity.
Mukovhe Phanguphangu, Lebogang Ramma
doaj   +1 more source

Practice of Monitoring Cisplatin-Induced Ototoxicity by Audiology, ENT, and Oncology Specialists: A Survey-Based Study in a Single Italian Medical Center

Audiology Research, 2023
Ototoxic drugs can result in hearing loss and tinnitus. Early detection of the ototoxic process can help minimize or prevent these consequences. The American Speech–Language–Hearing Association has provided guidelines for monitoring ototoxicity, whereas ...
Valeria Gambacorta, Eva Orzan, Mario Faralli, Mario Gullà, Ruggero Lapenna, Irene Baietta, Verena De Angelis, Giampietro Ricci   +7 more
doaj   +1 more source