The potential use of melatonin for preventing cisplatin ototoxicity : an insight for a clinical approach [PDF]
, 2014 Cisplatin, one of the most effective and potent anticancer drugs, is used in the treatment of a wide variety of both pediatric and adult malignancies.
Araujo, Juliana Gusmão de +3 more
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Re-telling the story of aminoglycoside ototoxicity: tales from sub-Saharan Africa
Frontiers in NeurologyBackgroundAminoglycosides, such as Streptomycin, are cheap, potent antibiotics widely used Sub-Saharan Africa. However, aminoglycosides are the commonest cause of ototoxicity.
Adebolajo A. Adeyemo +6 more
doaj +1 more source
Linear cyclodextrin polymer prodrugs as novel yherapeutics for Niemann-Pick type C1 disorder [PDF]
, 2018 Niemann-Pick Type C1 disorder (NPC) is a rare lysosomal storage disease characterized by the accumulation of cholesterol in lysosomes. NPC has no FDA approved treatments yet, however 2-hydroxypropyl-β-cyclodextrin (HPβCD) has shown efficacy for treating ...
Aditya Kulkarni +8 more
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After surviving cancer, what about late life effects of the cure?
EMBO Molecular Medicine, 2016 The widely used chemotherapeutic cisplatin causes ototoxicity as late‐term side effect. In this issue, Benkafadar et al (2017) decipher the mechanism of cisplatin‐induced ototoxicity and provide evidence that transient inhibition of p53 ameliorates ...
Julie Nonnekens, Jan HJ Hoeijmakers
doaj +1 more source
(-)-Epigallocatechin-3-gallate protects against NO-induced ototoxicity through the regulation of caspase- 1, caspase-3, and NF-κB activation. [PDF]
PLoS ONE, 2012 Excessive nitric oxide (NO) production is toxic to the cochlea and induces hearing loss. However, the mechanism through which NO induces ototoxicity has not been completely understood.
Su-Jin Kim +7 more
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Systematic review of ototoxic pre-surgical antiseptic preparations – what is the evidence?
Journal of Otolaryngology - Head and Neck Surgery, 2018 Objective There is uncertainty regarding the safety of surgical antiseptic preparations in the ear. A systematic review of the literature was conducted to assess the evidence regarding ototoxicity of surgical antiseptic preparations. Methods A literature
Shubhi Singh, Brian Blakley
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Insight into the current practice of ototoxicity monitoring during cisplatin therapy
Journal of Otolaryngology - Head and Neck Surgery, 2021 Background The aim of this study is to evaluate the current state of ototoxicity monitoring for patients receiving cisplatin chemotherapy in an academic medical center with particular attention to how closely monitoring adheres to national ototoxicity ...
N. M. Santucci +5 more
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Early assessment of vestibular function after unilateral cochlear implant surgery [PDF]
, 2019 Introduction : Cochlear implantation (CI) has been reported to negatively effect on the vestibular function. The study of the vestibular function has variably been conducted by different types of diagnostic tools. The combined use of modern, rapidly
Barbara, M +6 more
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Frontiers in Molecular Neuroscience, 2022 Cisplatin is one of the most widely used chemotherapeutic drugs across the world. However, the serious ototoxic effects, leading to permanent hair cell death and hearing loss, significantly limit the utility of cisplatin.
Jinan Li +4 more
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Journal of Otology, 2016 High levels of arsenic are found in many parts of the world and more than 100 million people may have been exposed to it. There is growing evidence to indicate that arsenic has a deleterious effect on the auditory system. This paper provides the general information of arsenic and its ototoxic effects.
openaire +3 more sources